M-methyl-N-

The Leuckart-Wallach reaction is the oldest method of reductive amination of carbonyl compounds. It makes use of formamide, formic acid or ammonium formate at high temperature. The final product is a formamide derivative, which can be converted to an amine by reduction or hydrolysis. The method has been applied to the preparation of 1,2-diamines with a norbornane framework, which are interesting rigid analogues of 1,2-diaminocyclohexanes. As a matter of fact, starting from N-acetyl-2-oxo-l-norbornylamine 222, the diamide 223 was obtained with excellent diastereoselectivity and then converted to the M-methyl-N -ethyl derivative 224 by reduction with borane [ 104] (Scheme 34). On the other hand, when the reac-... 

Vargas, H. M., Cuevas, J. M., Ignarro, L. J., and Chaudhuri, G. (1991). Comparison of the inhibitory potencies of M -methyl, N -nitro-, and N -amino-L-arginine on EDRF function in the rat Evidence for continuous basal EDRF release. J. Pharmacol. Exp. Ther. 257, 1208-1215. 

Beilstein Handbook Reference) BRN 0742170 EINECS 203-019-4 N-Ethyl-3-methylaniline HSDB 5347 m-Methyl-N-ethyianiline m-Toluidine, N-ethyl- NSC 8624 Toluene, 3-(ethylamino)-. Liquid bp = 221° d 0,9263 Xm = 247, 295 nm (cyclohexane) soluble in EtOH, Et20,... 

W-Ethyl-M-nitrosourea was decomposed faster with increasing concentrations of Cu (2.5-40 pmol/l) at pH 6 and 37 C in a concentration-dependent manner (Preussmann et al. 1975). Acceleration by NF was markedly weaker. In the presence of Cu the half life of M-methyl-N -nitro-hJ-nitrosoguanidin was only 39 min instead of 35 h. There was a linear relationship between the rate of degradation and the concentration of Cu or Ni ions. The metal ions enter the reaction in stoichiometric amounts. The elevation of the rate of decomposition completely agreed with the findings of Zeller and Ivankovich (1972) and Ivankovich etal. (1972) who observed an enhancement of the acute toxicity and the carcinogenicity of W-ethyl-W-nitrosourea administered simultaneously with CUSO4 or NiSO. ... 

Methyl- and dimethylnaphthalenes are contained in coke-oven tar and in certain petroleum fractions in significant amounts. A typical high temperature coke-oven coal tar, for example, contains ca 3 wt % of combined methyl- and dimethylnaphthalenes (6). In the United States, separation of individual isomers is seldom attempted instead a methylnaphtha1 ene-rich fraction is produced for commercial purposes. Such mixtures are used for solvents for pesticides, sulfur, and various aromatic compounds. They also can be used as low freezing, stable heat-transfer fluids. Mixtures that are rich in monomethyinaphthalene content have been used as dye carriers (qv) for color intensification in the dyeing of synthetic fibers, eg, polyester. They also are used as the feedstock to make naphthalene in dealkylation processes. PhthaUc anhydride also can be made from m ethyl n aph th al en e mixtures by an oxidation process that is similar to that used for naphthalene. 

M-Pjrol, N-Methyl-2-Pyrrolidone Handbook, GAP Corp., New York, 1972. 

Pargyline hydrochloride (Eutonyl, (V-methyl-n-propargylbenzylamine hydrochloride) [306-07-0] M 195.7, m 154-155 , 155 , pK 6.9. Recrystd from EtOH-Et20 and dried in vacuo. It is very soluble in H2O, in which it is unstable. The free base has b 101-103°/ 1mm. It is a glucuronyl transferase inducer and a monoamine oxidase inhibitor, [von Braun et al. Justus Liebigs Ann Chem 445 205 1928, Yeh and Mitchell Experientia 28 298 1972 Langslrom et al. Science 225 1480 1984.]... 

Cyan-kalium, n. potassium cyanide, -kalium-losung, /. potassium cyanide solution, -ko-balt, m. cobalt cyanide, -kohlensaure, / cyanocarbonic acid. -kupfer, n. copper cyanide, -laugerei, -laugung, /. cyaniding. cyanidation. -losung, / cyanide solution, -metall, n. metallic methyl cyanide, -natrium, n. sodium cyanide. -platin, n. platinum cyanide. 

Methyl-arsonsaure, /. methylarsonic (meth-anearsonic) acid, -ather, m. methyl ether, -blau, n. methyl blue, -chlorid, -chlordr, n. methyl chloride, chloromethane. Methylen-blsu, n. methylene blue, -gruppe, /. methylene group, -jodid, n. methylene iodide, diiodomethane. 

Methyl-ierung, -isiertmg, /. methylation. -jodid, n. methyl iodide, iodomethane. -kautschuk, m. methyl rubber. Methylostarke,/. methylstarch. Methyl-oxydhydrat, n. methyl hydroxide (meth-... 

Rhodan-ion, n. thiocyanogen ion, CNS -kali, -kalium, n, potassium thiocyanate, -kalzium, n. calcium thiocyanate, -kupfer, n. cupric thiocyanate, copper(II) thiocyanate. -iSsung, /. thiocyanate solution, -metall, n. (metallic) thiocyanate, -methyl, n. methyl thiocyanate, -natrium, n, sodium thiocyanate, -nickel, m. nickel thiocyanate, -quecksilber, n. mercury thiocyanate, -salz, n. thiocyanate, -sdure, /. (Org. Chem.) thiocyan(at)o acid, -tonerde, /. aluminum thiocyanate. 

N-(m-methylmercapto-phenyl)-aniline (MP 59° to 61°C) is prepared by condensing m-methyl-mercapto-aniline (BP 163° to 165°C/16 mm Hg) with the potassium salt of o-chloro-benzoic acid and decarboxylating the resultant N-(m-methylmercapto-phenyl)-anthranilic acid (MP 139° to 141°C) by heating, and then distilling. 

Chemical Name 0-(1,4-Methano-1,2,3,4-tetrahydro-6-naphthyl)-N-methyl-N-(m-tolyl)-thiocarbamate... 

Methyl m-tolyl (8), ethyl m-tolyl, methyl n-butyl and methyl n-propyl sulfoxides were obtained in 100% e.e. This method was less successful when applied to methyl phenyl sulfoxide (5% e.e.) or to methyl isobutyl and methyl ethyl sulfoxides (25% e.e.). No complexes were formed between methyl o-tolyl, methyl p-tolyl, methyl 2-butyl and methyl isopropyl sulfoxides so these compounds could not be resolved using 7. A crystal structure of the 1 1 complex formed between 7 and 8 revealed that the partners were linked by OH—OS hydrogen bonds in endless zig-zag chains23. More recently, 2-chloroethyl m-tolyl sulfoxide (9) has been resolved using 724. 

Synthesis of Chromose A (2,6-Dideoxy-4 G-methyl-n-galactose), J. S. Brimacombe, D. Portsmouth, and M. Stacey, Chem. Ind. (London), (1964) 1758. 

Jacobs. J.M, Carmichael, N., and Cavanagh, J.B. (1977). Ultrastructuralchanges in thenervons system of rabbits poisoned with methyl mercury. Toxicology and Applied Pharmacology 39, 249-261. 

A solution of 5 mmol diazomethane, prepared from N-methyl-N-nitrosourea (0.62 g, 6 mmol), in 5 mL pentane is added to 1728 a (0.5 g, 5 mmol) [4] at 0°C and the reaction mixture warmed to room temperature. After 30 min the yellow color of CH2N2 has disappeared and the reaction mixture is evaporated. The residue is extracted with boiling pentane to give 0.66 g (93%) 3-tert-butyl-lH-l,2,4-di-azaphosphol, m.p. 74°C [30] (Scheme 11.10). 

Cello- and malto-oligosaccharides up to nonasaccharides in the presence of various metal salts have been analyzed by f.a.b.-m.s. The structures of two methyl alduronates obtained by flash hydrolysis of wood chips was deduced by using f.a.b.-m.s., n.m.r. spectroscopy, and sugar analysis. ... 

In the spectrum of fully reductively [ C] methylated glycophorin A, the resonance at 42.8 p.p.m. must correspond to the N, N -di[ C]methylated, N-terminal amino acid residue. The ratio of the integrated intensities of the N, N -di[ C]methylLeu resonance to the N, N -di[ C]methyllysine resonances is 5 1, as expected. The integration values determined were valid, because the recycle times of spectra in Figs. 3B, 3C, and 3D were twice the spin-lattice relaxation-times (Tj values) of those of the di[ C]methyl carbon atoms, and also because the n.O.e. values of the N, N -di[ C]methyl and N, N -di[ C]methyl carbon atoms were equivalent. ... 

KIM J p, PARK J G, LEE M D, HAN M D, PARK s T, LEE B H, JUNG se(1985) Co-carcinogenic effects of several Korean foods on gastric cancer induced by N-methyl-N -nitro-N-nitrosoguanidine in rats. . Jpn J Surg. 15 427-37. 

TATSUTA M, iisHi H, BABA M, YANO H, UEHARA H, NAKAizuMi A (1999) Attenuation by genistein of sodiirm-chloride enhanced gastric carcinogenesis induced by N-methyl-N -nitro-N-nitrosoguanidine. Int J Cancer. 80 396-9. 

Tiripicchio, A., Tiripicchio Camellini, M. and Minghetti, G. (1979) The crystal structure of tris-p-[(ethoxy)(N-p-tolylimino)methyl-N, C]trigold(l), [(FtO)(MeC6H4N=)CAu]j. Journal... 

---