Lymphoma mediastinal

Anaplastic large cell lymphoma, Reed-Sternberg cells in classic Hodgkin s lymphoma, mediastinal large B-cell lymphoma... [Pg.60]

This royal-blue-colored drug is an anthracenedione that inhibits DNA topoisomerase II. The pharmacokinetics of mitoxantrone may best be described by a three-compartment model, with an a half-life of 3 to 10 minutes, a 3 half life of 0.3 to 3 hours, and a median terminal half-life of 12 days. Biliary elimination appears to be the primary route of elimination, with less than 10% of the drug eliminated by the kidney.23 Mitoxantrone has shown clinical activity in the treatment of acute leukemias, breast and prostate cancer, and non-Hodgkin s lymphomas. Myelosuppression, mucositis, nausea and vomiting, and cardiac toxicity are side effects of this drug. The total cumulative dose limit is 160 mg/m2 for patients who have not received prior anthracycline or mediastinal radiation. Patients who have received prior doxorubicin or daunorubicin therapy should not receive a cumulative dose greater than 120 mg/m2 of mitoxantrone. Patients should be counseled that their urine will turn a blue-green color. [Pg.1289]

Cytotoxic chemotherapy is the treatment of choice for chemotherapy-sensitive tumors such as SCLC and lymphoma. As indicated earlier, chemotherapy also may be combined with radiotherapy, especially in patients with lymphoma who have bulky mediastinal lymphadenopathy. [Pg.1475]

Suggested Alternatives for Differential Diagnosis Blastomycosis, coccidioidomycosis, aspergillosis, pneumonia, respiratory distress syndrome, mediastinal cysts, mycoplasma infections, Pancoast syndrome, sarcoidosis, tuberculosis, lung abscess, lung cancer, lymphoma. [Pg.610]

A 60-year-old woman took dexamethasone 4 mg 8-hourly for dyspnea due to a precursor T lymphoblastic lymphoma-leukemia with bilateral pleural effusions and a large mass in the anterior mediastinum (130). She developed acute renal insufficiency and laboratory evidence of the metabolic effects of massive cytolysis. She received vigorous hydration, a diuretic, allopuri-nol, and hemodialysis. She recovered within 2 weeks and then underwent six courses of CHOP chemotherapy. The mediastinal mass regressed completely. She remained asymptomatic until she developed full-blown acute lymphoblastic leukemia, which was resistant to treatment. [Pg.19]

A 26-year-old pregnant woman with a mediastinal lymphoma that did not accumulate Ga (9). [Pg.1477]

PMBL primary mediastinal large B-cell lymphoma... [Pg.2463]

Primary mediastinal B-cell lymphoma (PMBCL) can be confused with HL because it presents as a mass in the anterior mediastinum of young adults and often contains FI/RS-like cells in a background of collagen sclerosis (Fig. [Pg.146]

FIGURE 5.19 Hodgkin/Reed-Sternberg-like cells in primary mediastinal B-cell large cell lymphoma. [Pg.149]

Paulli M, Strater J, Gianelli U, et al. Mediastinal B-cell lymphoma A study of its histomorphologic spectrum based on 109 cases. Hum Pathol. 1999 30 178-187. [Pg.154]

Higgins JP, Warnke RA. CD30 expression is common in mediastinal large B-cell lymphoma. Am J Clin Pathol. 1999 112 241-247. [Pg.155]

Feuerhake F, Kutok JL, Monti S, et al. NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypes. Blood. 2005 106 1392-1399. [Pg.155]

Savage KJ, Monti S, Kutok JL, et al. The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma. Blood. 2003 102 3871-3879. [Pg.155]

Typical phenotype B-cell antigen -1-, CD45RB-I-, CD20-I-, PAX5-I-, CD19-I-, CD79-I- (except for some anaplastic and mediastinal lymphomas), CD5-/-I-, CDlO-Z-i-... [Pg.175]

MEDIASTINAL LARGE B-CELL LYMPHOMA 26 unique entity... [Pg.175]

Davis RE, Dorfman RF, Warnke RA. Primary large-cell lymphoma of the thymus a diffuse B-cell neoplasm presenting as primary mediastinal lymphoma. Hum Pathol. 1990 21(12) 1262-1268. [Pg.187]

Rodriguez J, Pugh WC, Romaguera JE, et al. Primary mediastinal large cell lymphoma. Hematol Oncol. 1994 12(4) 175-184. [Pg.187]

MEDIASTINAL LARGE-CELL NON-HODGKIN LYMPHOMA (TABLE 11.6 FIG. 11.25)... [Pg.355]

Hodgkin lymphoma (HL) is the most common cyto-logically malignant mediastinal neoplasm.1 2 Although it is thought to arise in the thymus or perithymic lymph... [Pg.355]

Yu GH, Salhany KE, Gokaslan ST, et al. Thymic epithelial cells as a diagnostic pitfall in the fine needle aspiration diagnosis of primary mediastinal lymphoma. Diagn Cytopathol. 1997 16 460-465. [Pg.364]

Perrone T, Frizzera G, Rosai J. Mediastinal diffuse large-cell lymphoma with sclerosis A clinicopathologic study of 60 cases. Am J Surg Pathol. 1986 10 176-191. [Pg.365]

Shikano T, Arioka H, Kobayashi R, et al. Acute lymphoblastic leukemia and non-Hodgkin s lymphoma with mediastinal mass—A study of 23 children different disorders or different stages Leuk Lymphoma. 1994 13 161-167. [Pg.366]

Trump DL, Mann RB. Diffuse large cell and undifferentiated lymphomas with prominent mediastinal involvement A poor prognostic subset of patients with non-Hodgkin s lymphoma. Cancer. 1982 50 277-282. [Pg.366]

Strickler JG, Kurtin PL Mediastinal lymphoma. Semin Diagn Pathol. 1991 8 2-13. [Pg.366]

Al-Sharabati M, Chittal S, Duga-Neulat, et al. Primary anterior mediastinal B-cell lymphoma A clinicopathologic and immunohistochemical study of 16 cases. Cancer. 1991 67 2579-2587. [Pg.367]

Martelli M, Ferreri AJ, Johnson P. Primary mediastinal large B-cell lymphoma. Crit Rev Oncol Hematol. 2008 68 256-263. [Pg.367]

Lazzarino M, Orlandi E, Paulli M, et al. Treatment outcome and prognostic factors for primary mediastinal (thymic) B-cell lymphoma A multicenter study of 106 patients. J Clin Oncol. 1997 15 1646-1653. [Pg.367]

Ghubachi A, Mitrra I, Takahashi N, et al. Acute myelogenous leukemia associated with a mediastinal mmor. Leuk Lymphoma. 1993 12 143-146. [Pg.367]

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