Lymphoid-enhancing factor

Persad S, Troussard AA, McPhee TR, Mulholland DJ, Dedhar S. Tumor suppressor PTEN inhibits nuclear accumulation of beta-catenin and T cell/lymphoid enhancer factor 1-mediated transcriptional activation. J. Cell. Biol. 2001 153 1161-1174. Yang Y, Guo L, Blattner SM, Mundel P, Kretzler M, Wu C. Formation and phosphorylation of the PINCH-l-integrin linked kinase-alpha-parvin complex are important for regulation of renal glomerular podoc)4e adhesion, architecture, and survival. J. Am. Soc. Nephrol. 2005 16 1966-1976. 

T-cell factor/lymphoid enhancer factor). TCF/LEF in turn binds and activates the ABCBl promoter [137]. 

LEFl lymphoid enhancer-binding factor lisa 48-kDa nuclear protein expressed in pre-B and T cells. LEFl binds to a functionally important site in the T-cell receptor-alpha enhancer and confers maximal enhancer activity. LEFl belongs to a family of regulatory proteins that share homology with high mobility group protein-1. 

DuanD, Yue Y, ZhouW, etal. Submucosal Gland Development in the Airway is Controlled by Lymphoid Enhancer Binding Factor-1 (Lef-1). Development... 

Another mechanism that may contribute to TAC-induced renal fibrosis is increased IL-6 production through NF-Kappa B activation of non-lymphoid cells. Tacrolimus stimulates this inducible transcription factor, which enhances IL-6 production in fibroblasts and mesangial cells. IL-6 in turn triggers mesangial cell proliferation and extracellular matrix production [651, 766]. Inhibition of NF-Kappa B suppressed monocyte/macrophage renal infiltration and attenuated interstitial fibrosis and tubular atrophy in TAC treated rats [767, 768]. 

In the case of griseofulvin, administration in a fatty medium enhances absorption. Fat is emulsified by the bile salts, and the administration of an already emulsified form increases the opportunity for solubilisation and hence transport across the microvilli by fat absorption pathways. The influence of the emulsifier on membrane permeability is one factor that must be considered. Knowledge that particles may be absorbed from the gut by the gut-associated lymphoid tissue suggests that we may have to revise our views on the nature of absorption of many dmgs from the gastrointestinal tract. 

Thus, the bulk of evidence available to date would suggest at least in mice that the spleen contains a population of thymic hormone-responsive lymphoid cells that functions mainly in the suppression of immune responses, perhaps masking concomitant helper effects. In the thymus, the predominant effects of thymic peptides appear to be the induction of functional helper cells, possibly by the enhancement of lymphokine production. The effects of thymulin, thymosin, or other thymic factors on IL-2 production may indeed represent a major function of the endocrine thymus, since IL-2 has been shown to be a potent physiological promoter of T cell maturation (Ruscetti and Gallo, 1981). 

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