Inducible transcription factors

Since the endogenous levels of inducible transcription factors like NF-kB and NFAT (Duh et al. 1989 Kinoshita et al. 1997) in these cells have been reported to be very low, HIV-1 promoter activation is inefficient resulting in non-expression of viral gene products (Figs. 5.1 and 5.2). Therefore, these cells can escape immune surveillance and act as passive carriers of HIV-1 for their natural lifespan. 

Shaywitz, A.J., Greenberg, M.E. CREB a stimulus-induced transcription factor activated by a diverse array of extracellular signals. Annu. Rev. Biochem. 68 821, 1999. 

Ahmad, M. and Medford, R. M. Evidence for the regulation of Na+, K+-ATPase alpha 1 gene expression through the interaction of aldosterone and cAMP-inducible transcriptional factors. Steroids 60 147-152,1995. 

Naoumkina MA, He XZ, Dixon RA (2008) Ehcitor-induced transcription factors for metabolic reprogramming of secondary metabolism in Medicago truncatula. BMC Plant Biol 8 132... 

K., Seckl, J.R., (2000) Postnatal handling increases the expression of cAMP inducible transcription factors in the rat hippocampus effects of thyroid hormone and serotonin /. Neurosci 20 3926-3935. 

Bruce, W. et al.. Expression profiling of the maize flavonoid pathway genes controlled by estradiol-inducible transcription factors CRC and P. Plant Cell, 12, 65, 2000. 

Nuclear factor kappa B (NF-kB) serves as a central regulator of the human immune and inflammatory response, and is a family of inducible transcription factors found virtually ubiquitously in all cells and functions in a variety of human diseases including those related to inflammation, cancer, asthma, atherosclerosis, AIDS, septic shock, and arthritis. Due to its role in a wide variety of diseases, NF-kB has become one of the major targets for drug development. Inhibition of NF-kB activity potentially contributes to cancer chemoprevention [27,28]. 

Kallio, P.J., W.J. Wilson, S. O Brien, Y. Makino, and L. Poellinger (1999). Regulation of the hypoxia-inducible transcription factor 1 alpha by the ubiquitin-proteasome pathway. J. Biol. Chem. 274 6519-6525. 

Nuclear receptors (NRs) are ligand-inducible transcription factors consisting of a ligand-binding domain (LBD) and a DNA-binding domain (DBD). NRs are... 

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