Losec

Losec (omeprazole) Duodenal ulcer Gastro-oesophageal reflux Helicobacter infections 5.7 1.9 1989 - UK and US Once daily, except when used as part of combination therapy... 

Losec, Prilosec Losec MUPS, Prilosec MUPS... 

All products include omeprazole as active ingredient. Losec and Prilosec are original medicinal products in Europe and USA respectively. MUPS (Multi Unit Pellet System) is also an original trade name and drug formulation... 

Losec MUPS XPharma is identical to the original and parallel imported by XPharma... 

Omeprazole Each particle in the capsule is protected by an acid stable content that must not be crushed. The granules in the capsule can be too large for tube administration. Change drug. Another proton-pump inhibitor with smaller granules such as Nexium or Prilosec/Losec MUPS. Special instructions are available... 

Our second interesting case of chirality is an example of advertising trumping science. In this case, the molecule in question is known generically as esomeprazole and is marketed in the United States as Nexium, widely advertised as the purple pill. The story begins with a closely related molecule, omeprazole, marketed as Losec or Prilosec. 

Losec MUPS is a proprietary preparation of omeprazole available as dispersible tablets that can be dispersed either in water or fruit juice. Tablets should not be chewed. 

Q86 Patients receiving Losec capsules should be advised to swallow the capsule whole. Losec capsules consist of enteric-coated granules, as omeprazole is acid-labile. 

Losec consists of omeprazole, a proton pump inhibitor. Proton pump inhibitors are acid-labile. Losec consists of enteric-coated granules that are encapsulated. Patients are advised to swallow the capsule whole. 

Compatibility with metals, most metals are unaffected in contact with dry expl most are heavily corroded by wet expl, Al Sc stainless steel are unaffected Detonation rate, 7570m/sec at d 1.49g/cc Explosion temperature, 2169 in lsec, dec 189° In 5secs, and, 1789 in lOsecs Flammability index, 138 (TNT = 100)... 

Sections (7 xm thick) of freshly frozen tissues are mounted on silane-coated slides and fixed with 4% buffered formaldehyde (pH 7.0) for 20 sec (Richter et al., 1999). The sections are rinsed in TBS (pH 7.4) for 15 sec, followed by incubation with EPOS antibody for 3 min at 37°C in an incubation chamber. They are rinsed twice for 15 sec each in TBS, and then developed with peroxidase-DAB detection kit (Dako) in a microwave oven (500 W) for 1 min during microwaving, the slides are cooled by a cold water bath (Werner et al., 1991). After being rinsed in tap water, the sections are counterstained with hematoxylin for lOsec. They are rinsed in tap water and cover-slipped. 

The proton pump (H+K+ATPase) of the apical membrane of the parietal cells is the ultimate mechanism that governs acid secretion. Among a family of benzimidazole derivatives, omeprazole (Losec) promotes the healing of ulcers in the stomach, duodenum, and esophagus, and is of special value in patients who do not respond to H2-receptor antagonists. 

Dogrukol-Ak et al. [55] determined omeprazole in pharmaceutical preparations by a TLC densitometric method. Pellets from eneric coated capsules were finely powdered and dissolved in ethanolic 0.05 M potassium hydroxide with sonication. Four microliters of the solution was subjected to TLC on a silica gel FG254 plates with chloroform-methanol-25% ammonia (97.5 2.5 1) as mobile phase and densitometric detection of omeprazole (Rf = 0.46) at 302 nm. Calibration graphs were linear for 0.42—1.68 jug omeprazole the detection limit was 25 ng. In the determination of omeprazole in 20 mg Omeprazit, Omeprol, and Losec capsules, the found amounts were 20.2, 20.3, and 19.8 mg omeprazole, respectively, with corresponding RSD 1.9,1.8, and 1.6% (n = 8). The results agree with those of UV spectrophotometry. 

In 1998 the first tablet containing enteric-coated particles was marketed (Losec Mups, Omeprazole-Magnesium by ASTRA, Sweden). This is a new prin-... 

Fordex Gastrium Gastrotem Helicid 10 Helicid 11 Lenar Lomak Losec... 

Losec (Plough 1990) Mepral (Bracco 1990) Omeprazen (Malesci ... 

In 1988, after extensive documentation and careful evaluation, omeprazole was registered in Sweden for the treatment of duodenal ulcer and reflux esophagitis, and was launched in Europe as Losec in the same year. The clinical program continued to document the value of omeprazole in further acid-related disorders, though its full therapeutic potential became apparent only during the 1990s, when it superseded the Hrreceptor antagonists in the treatment of all these conditions. 

The Treatment of Acid-Related Disorders Before Losec 81... 

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