Tumour localization

Croll, MN, LW Brady, T. Honda and RJ, Waliner., Eds., New Techniques in Tumour Localization and Radioimmunoassay , New York, Wiley 1974. 

Harden, L., Eriksson, M. Dcgcrmann, A. (1995) Meta-analysis of four Swedish case-control studies on exposure to pesticides as risk-factor for soft-tissue sarcoma including the relation to tumour localization and histopathological type. Int. J. Oncol., 6, 847-851... 

Selectivity. The selectivity of photosensitizers can be also affected by central metal ions and substituents at the macrocycle, eg tetrasulphonated chloroaluminium phthalocyanine [Al(pcS4)Cl] localizes well in the tumour, whereas tetrasulphonated zinc phthalocyanine [Zn(pcS4)] (and also disulphonated zinc phthalocyanine [Zn(pcS2)]) shows a relatively poor tumour localization [207],... 

Scintigraphy Hepatobiliary sequential scintigraphy imaging using T-etifenin can often provide additional information about tumour localization. Fluoro-2-deoxy-D glucose PET may be helpful in the diagnosis of perihilar CCC or metastasis. 

Northfelt DW, Martin FJ, Working P, Volberding PA, Russell J, Newman M, Amantea MA, Kaplan LD (1996) Doxorubicin encapsulated in liposomes containing surface-bound polyethylene glycol pharmacokinetics, tumour localization, and safety in patients with AIDS-related Kaposi s sarcoma. J CKn Pharmacol 36(l) 55-63... 

The criteria for inclusion of animals in the study were a biopsy proven osteosarcoma and a positive Tc-methylene diphosphonate scan for tumour localization. Fourteen dogs were used for the study. Animals that met the inclusion criteria received a single injection of Rc-HEDP with an activity ranging from 1.1 to 2.3 GBq, depending on the body size of the animal. 

HEPPELER, A., FROIDEVAUX, S., EBERLE, A.N., MAECKE, H.R.. Receptor targeting for tumour localization and therapy with radiopeptides, Curr. Med. Chem. 7 (2000) 7971-7994. 

A complete understanding of why specific metal complexes target certain tissues has yet to be achieved, but would be extremely valuable for the rational design of new radiopharmaceuticals. Complexes of 99mTc vvilli diphosphonates, e.g. methylenediphosphonate, localize in bone and especially in areas of disturbance of bone metabolism, such as tumours thus they may be used to map the presence and location of bony metastases from various types of cancer. Chelates such as "Tc-DTPA may be used to study differential renal function in the kidneys or to monitor the function of a transplanted kidney. Attachment of chelating groups, often based on DTPA, to antibody proteins permits the formation of Tc- or in-labelled antibodies for tumour localization. 

Time gated fluorescence spectroscopy of the tumour localizing fraction of haematoporphyrin derivative, used as a photochemically destructive sensitizer, in the presence of cationic surfactant... 

Indium-Ill Accelerator Imaging agent for tumour localization... 

Potassium-42 Reactor Brain and breast tumour localization determination of total exchangeable K-t- renal blood flow measurement... 

Overall, the primary success rates of RFA in liver, kidney, lung and bone tumours range from 70% to more than 95%, depending on the tumour localization and type - assuming the above-mentioned advice has been considered. 

In this setting, thermal ablation will be mainly a symptomatic, supportive (palliative) therapy, which can also be applied in conjunction with other therapies such as resection, radiotherapy or chemotherapy. In contrast to the treatment of malignant tumours, local thermal ablation is considered the method of choice in treatment of symptomatic benign bone tumours such as osteoid osteomas. 

Section 7.4), include Co(n) and Co(III) [18-22], Mn(II) [23, 24], Zn(II) [25, 26], Ni(H) [27], Ru(III) [28], Tc [29], and V(IV) [30]. Earlier results have been summarized [3]. Many of these examples may be considered to be attempts at producing tumour-localizing agents, combining the known affinity of bleomycin for tumour cells with a suitably stable metal radiolabel. The metallation does appear to affect tissue distribution, which may imply an alteration in functional structure of the drug. A study of the cytotoxic and antitumour properties of some metal complexes gave an order of activity in culture and antitumour potency of Cu(II)BLM > BLM >Zn(II)BLM >Fe(III)BLM Co(II)BLM [31]. 

Fabris, C. Vicente, M. G. H. Hao, E. Friso, E. Borsetto, L. Jori, G. Miotto, G. etal.,Tumour-localizing and -photosensitising properties of mew-tetra(4-nZ[Pg.239]

In vivo 3iP NMR and P magnetic resonance imaging are also important applications of this nucleus. 3ip signals from inorganic phosphate, adenosine triphosphate, adenosine diphosphate, creatine phosphate, and sugar phosphates can be observed in whole-cell preparations, intact tissues, and whole bodies and can provide information on the viability of the cells and tumour localization. Low sensitivity continues to be a problem in widespread application of these techniques. Additional details can be found in several of the entries in the Eurther reading section. 

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