Metabolic monitoring

K.R. Khabbaz, F. Zankoul, and K.G. Warner, Intraoperative metabolic monitoring of the heart ... [Pg.325]

Macrolides/azalides Digoxin Decreased digoxin bioavailability and metabolism Monitor digoxin SDC avoid if possible... [Pg.396]

R.L. Wahl, K. Zasadny, M. Helvie, G.D. Hutchins, B. Weber, R. Cody, Metabolic monitoring of breast cancer chemohormonotherapy using positron emission tomography Initial evaluation, J. Clin. Oncol. 11(11) (1993) 2101-2111. [Pg.185]

Variable effect on renal function and cyclosporine metabolism. Monitor cyclosporine levels and renal function carefully... [Pg.49]

Hillered L, Persson L (1991) Miciodialysis for metabolic monitoring in cerebral ischemia and trauma Experimental and clinical studies. In Microdialysis in the Neurosciences. Techniques in the Behavioral and Neural Sceinces, Vol. 7, TE Robinson and JB Justice Jr, Eds., pp. 389-405. Elsevier Science Publishers, Amsterdam. [Pg.132]

PROPAFENONE ANTICOAGULANTS-ORAL Warfarin levels may be t by propafenone Propafenone seems to inhibit warfarin metabolism Monitor INR at least weekly until stable... [Pg.32]

VASODILATOR ANTIHYPERTENSIVES BETA-BLOCKERS t hypotensive effect Additive hypotensive effect with diazoxide, hydralazine, minoxidil and sodium nitroprusside. In addition, hydralazine may T the bioavailability of beta-blockers with a high first-pass metabolism (e.g. propanolol and metoprolol), possibly due to alterations in hepatic blood flow or inhibited hepatic metabolism Monitor BP closely... [Pg.47]

CALCIUM CHANNEL BLOCKERS ANTIGOUT DRUGS Serum concentrations pf verapamil are significantly 1 when co-administered with sulfinpyrazone Uncertain, but presumed to be due to t hepatic metabolism Monitor PR and BP at least weekly until stable. Watch for poor response to verapamil... [Pg.88]

CALCIUM CHANNEL BLOCKERS CALCIUM CHANNEL BLOCKERS Co-administration of nifedipine and diltiazem leads to t plasma concentrations of both drugs Uncertain, but presumed mutual inhibition of CYP3A isoform-mediated metabolism Monitor PR, BP and ECG at least weekly until stable. Warn patients to report symptoms of hypotension (light-headedness, dizziness on standing, etc.)... [Pg.92]

CALCIUM CHANNEL BLOCKERS CIMETIDINE t levels of calcium channel blockers, especially diltiazem and nifedipine Inhibition of CYP3A isoform-mediated metabolism Monitor BP at least weekly until stable watch for i BP. Consider reducing the dose of diltiazem and nifedipine by up to 50%... [Pg.94]

SSRIs FLECAINIDE, MEXILETINE, PROCAINAMIDE SSRIs may T levels of these antiarrhythmics SSRIs inhibit CYP2D6-mediated metabolism Monitor PR and BP closely watch for toxicity... [Pg.170]

FLUVOXAMINE PROTON PUMP INHIBITORS -OMEPRAZOLE 1 fluvoxamine levels with loss of therapeutic efficacy Inhibition of CYP1 A2-mediated metabolism Monitor for lack of therapeutic effect. When omeprazole is withdrawn, monitor for fluvoxamine toxicity... [Pg.179]

ST JOHN S WORT VINCA ALKALOIDS -VINBLASTINE, VINCRISTINE L of plasma concentrations of vinblastine and vincristine, with risk of inadequate therapeutic response. Reports of AUC 1 by 40%, elimination half-life 1 by 35%, and clearance t by 63% in patients with brain tumours taking vincristine Due to induction of CYP3A4-mediated metabolism Monitor for clinical efficacy, and T dose of vinblastine and vincristine as clinically indicated in the latter case, monitor clinically and radiologi-cally for clinical efficacy in patients with brain tumours, and T dose to obtain the desired response... [Pg.192]

CARBAMAZEPINE ISONIAZID t carbamazepine levels Inhibition of metabolism Monitor carbamazepine levels... [Pg.216]

LAMOTRIGINE 1. ANTIBIOTICS -rifampicin 2. OESTROGENS 3. PROGESTOGENS 1 lamotrigine levels t metabolism Monitor levels... [Pg.219]

PHENYTOIN CHLORAMPHENICOL, CLARITHROMYCIN, ISONI-AZID, METRONIDAZOLE, SULPHONAMIDES, TRIMETHOPRIM t phenytoin levels Inhibited metabolism Monitor phenytoin levels... [Pg.221]

VALPROATE ERYTHROMYCIN t valproate levels Inhibited metabolism Monitor levels... [Pg.226]

BROMOCRIPTINE, CABERGOUNE ERYTHROMYCIN t bromocriptine and cabergoline levels Inhibition of metabolism Monitor BP closely and watch for early features of toxicity (nausea, headache, drowsiness)... [Pg.244]

CHLORMETHIAZOLE H2 RECEPTOR BLOCKERS -CIMETIDINE t efficacy and adverse effects, e.g. sedation, hangover effect Inhibition of metabolism Monitor closely l dose may be required... [Pg.272]

DOXORUBICIN ANTIEPILEPTICS -BARBITURATES i doxorubicin levels Induction of hepatic metabolism Monitor for 1 efficacy of doxorubicin... [Pg.301]

CICLOSPORIN GRISEOFULVIN 1 plasma concentrations of ciclosporin (may be as much as 40%) and risk of rejection in patients who have received transplants Induction of ciclosporin metabolism Monitor ciclosporin levels closely... [Pg.362]

CORTICOSTEROIDS PROTEASE INHIBITORS-RITONAVIR t plasma levels of betamethasone, dexamethasone, hydrocortisone, prednisolone and both inhaled and intranasal budesonide and fluticasone with ritonavir (with or without lopinavir) Inhibition of CYP3A4-mediated metabolism Monitor closely for signs of corticosteroid toxicity and immunosupression, and i dose as necessaiy. Consider using inhaled bedometasone... [Pg.372]

INTERFERON ALFA BRONCHODILATORS -THEOPHYLLINE t theophylline levels Inhibition of theophylline metabolism Monitor theophylline levels before, during and after co-administration... [Pg.375]

THYROID HORMONES RIFAMPICIN 1 levothyroxine levels Induction of metabolism Monitor TFTs regularly and consider t dose of levothyroxine... [Pg.456]

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