Diethylenetriamine pentaacetic acid, and

Rebizak, R., Schaefer, M. and Dellacherie, E., 1997, Polymeric conjugates of Gd diethylenetriamine pentaacetic acid and dextran 1. Synthesis, characterization and paramagnetic properties. Bioconjug. Chem., 8(4) 605-610... 

Brechbiel, M. W., Beitzel, P. M., and Gansow, O. A., Purification of p-nitroben-zyl C-functionalized diethylenetriamine pentaacetic acids for clinical applications using anion-exchange chromatography, J. Chromatogr A, 771, 63,1997. 

Materials. Egg phosphatidylcholine (PC), bovine brain phosphatidylserine (PS) were obtained from Avanti Polar Lipids Inc. (Birmingham, AL) and cholesterol was from Sigma (St. Louis, MO). Ganglioside GMj, bovine, was obtained from Calbiochem (San Diego, CA). Diethylenetriamine pentaacetic acid distearylamide complex (DPTA-SA) was synthesized according to ref. 17 and nlIn-DTPA-SA was prepared as described (7). This lipophilic radiolabel is not transferred to the serum components from liposomes (unpublished data), nor is it rapidly metabolized in vivo (7). The synthesis of N-(glutaryl)phosphatidylethanolamine(NGPE) has been described (18). Dipalmitoyl deoxyfluorouridine(dpFUdR) was synthesized as described (24). 

Chan, H-K., Daviskas, E., Eberl, S., Robinson, M., Bautovich, G., and Young, I.H., Deposition of aqueous aerosol of technetium-99m diethylenetriamine pentaacetic acid generated and delivered by a novel system (AERx) in healthy subjects, Eur. J. Nucl. Med., 26 320-327 (1999). 

AAS = atomic absorption spectrometry DPTA = diethylenetriamine pentaacetic acid HNO3 = nitric acid ICP-AES = inductively coupled plasma-atomic emission spectroscopy Ni = nickel NIOSH = National Institute for Occupational Safety and Health... 

The free ion, Cu2+, appears to be the major species of Cu taken up by plants (Graham, 1981 Jones and Jarvis, 1981). Hence Cu complexation will decrease uptake (DeKock and Mitchell, 1957) unless the complex can dissociate and/or diffuse quickly enough to maintain a constant supply of Cu2+ at the root surface. In the case of Zn, the presence of humic acid (Chen and Aviad, 1990) and carboxylic acids (EDTA, diethylenetriamine pentaacetic acid (DTPA), nitrilotriacetic acid (NTA) DeKock and Mitchell, 1957) has been found to decrease absorption but it is not known whether Zn uptake is correlated with Zn2+ in solution because Zn speciation was not estimated. Other work has shown that Zn initially complexed with citrate is taken up by barley from nutrient solutions (Chairidchai and Ritchie, 1993) and the presence of chelates (EDTA, citrate) can speed up the diffusion of Zn to a root surface in soils (Hodgson et al., 1967 Elgawhary et al., 1970). Speciation in solution is particularly important in the uptake of iron because of its extremely low solubility in the absence of complexing anions... 

Dose-response relationship The qnantitative relationship between the amonnt of exposnre to a chemical snbstance and the extent of toxic injury or disease in body fnnction or health (response) prodnced DTPA Diethylenetriamine pentaacetic acid... 

Quintana, J.B. and Reemtsma, T. Rapid and sensitive determination of ethylenediamine tetraacetic acid and diethylenetriamine pentaacetic acid in water samples by ion-pair reversed-phase hquid chromatography-electrospray tandem mass spectrometry. /. 

Figure 3.2S The structure of (a) [Dy(H20)(DTPA)] and (b) [Dy2(DTPA)2] [Dy, black (large balls) O, grey N, black (small balls) C, white H, omitted)]. (Redrawn from the CIF files of J. Wang et al, Syntheses and structural determinations of the nine-coordinate rare earth metal Na4[Dy "(dtpa)(H20)]2 l6H20, Na[Dy "(edta)(H20)3]-3.25H20 and Na3[Dy (nta)2(H20)]-5.5H20, Journal of Coordination Chemistry, 60 (20), 2221-2241, 2007 [106] and Y. Inomata, T. Sunakawa and F.S. HoweU, The syntheses of lanthanide metal complexes with diethylenetriamine-N, N, N, N", N"-pentaacetic acid and the comparison of their crystal structures, Journal of Molecular Structure, 648 (1-2), 81-88, 2007 [107].)...

Inomata, Y, Sunakawa, T., and Howell, F.S. (2007) The syntheses of lanthanide metal complexes with diethylenetriamine-N, N, N, N",N"-pentaacetic acid and the comparison of their crystal structures. Journal of Molecular Structure, 648 (1-2), 81-88. 

RELATE 80 is an aqueous solution of the pentasodium salt of diethylenetriamine pentaacetic acid. It is more stable to oxidation and forms more stable complexes with some metal ions than EDTA type chelating agents. 

Tc-DTPA Arterial perfusion accounts for 20%-40% of the circulation in portal hypertension, cirrhosis causes arterial perfusion to increase to over 60%. In portal vein thrombosis, only an arterial curve is visible. Liver metastasis usually displays relatively high arterial perfusion. In (rare) occlusions of the hepatic artery, only a portal venous curve is visible. When a bolus injection of 400 MBq "Tc-diethylenetriamine pentaacetic acid (DTPA) is applied, scintigraphy is able to reveal a bi-phasic time-activity curve. The initial increase of activity is produced by the arterial influence and the second peak by the portal venous inflow. Both curves can be evaluated quantitatively. (36) Perfusion scintigraphy may be useful in the case of liver trauma, TIPS, hyper-vascularized hepatic tumours and partial liver resection as well as after liver transplantation. 

Fig. 4 The nasal clearance of bioadhesive formulations and a control in human volunteers. DTPA = diethylenetriamine-pentaacetic acid. (From Ref. " l)...

Other metal cations that may form complexes with the toxicant may have a profound effect on toxicity. The toxicity of ethylenedi-amine tetraacetic acid (EDTA) and diethylenetriamine pentaacetic acid (DTPA) and their metal complexes has been examined in daphnids. The results are relevant both for the effect on the toxicity of metal cations and for the influence of complexation on these toxicities. For the acute toxicity (ECS0, 24 h) to Daphnia magna, the following results (mg/1) were obtained (Sorvari and Silanpaa 1996) ... 

Because of the involvement of metal ions in degradation reactions, the inclusion of a chelating agent is often advocated. The most commonly used chelating agent are the various salts of EDTA. In addition, (3-hydroxyethylenediaminetriacetic acid (HEDTA), diethylenetriamine-pentaacetic acid (DTPA) and nitrilotriacetate (NTA) have been assessed for their efficiency in stabilizing, e.g., isoniazid solutions (Ammar et al. 1982). 

A. A radioactive material must be eliminated from the body to remove its hazard. Detoxification, which is effective against chemical hazards, will not be effective since radioactivity is not modified by chemical changes. The methods of elimination include renal excretion for most soluble materials, elimination in the feces for materials that are retained in the gut or which can be secreted in the bile, and exhalation for volatile materials and gases. Chelating agents, e.g., calcium or zinc DTPA (diethylenetriamine pentaacetic acid), if administered soon after exposure, are effective in enhancing the elimination of certain radioisotopes. These materials are not very effective for radioisotopes that have been incorporated and fixed in organs and tissues, e.g., bone. 

Fig. 1. The effect of cuprozinc and manganosuperoxide dismutase on the disproportionation of O2. O2 stock solution was added to 50 mM 2-amino-2-methyl-1-propanol HCI, pH 9.5, + 0.2 mAf diethylenetriamine pentaacetic acid -l-100 nM catalase. The decay in A250 was followed in the absence and presence of superoxide dismutase ( ) spontaneous reaction (O) 85 pM human cuprozinc superoxide dismutase (A) 350 pM bovine manganosuperoxide dismutase. (Reprinted with permission from S. Marklund.y.Bio/. Chem.,251,7504—7507,1976.)...

Pierzynski and Jacobs (1986) tested the suitability of AAO extraction and ammonium bicarbonate-diethylenetriamine pentaacetic acid (AB-DTPA) extraction for assessing available soil Mo. The procedure of AB-DTPA-extractable Mo was found to be more suitable for predicting Mo responses than was the AAO extraction procedure. 

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