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Liver idiosyncratic reactions

Monitoring Observe for blood dyscrasias, liver or kidney damage, or idiosyncratic reactions. Perform frequent serum electrolyte, calcium, glucose, uric acid, CO2,... [Pg.689]

When triamterene is added to other diuretic therapy, or when patients are switched to triamterene from other diuretics, discontinue potassium supplementation. Hypersensitivity reactions Monitor patients regularly for blood dyscrasias, liver damage, or other idiosyncratic reactions. [Pg.700]

Hepatic dysfunction and urinary abnormalities were seen In some subjects after CS exposure at Edgewood. Little is known of the effects of CS on the kidneys and liver. The small proportion of subjects who had abnormal urinalysis (7 of 50 14Z) and high transaminase (3 of 50 6Z) Indicates Idiosyncratic reactions, If the abnormalities were indeed due to CS exposure. The most likely course of idiosyncratic drug-induced, nonfulmlnant hepatitis is complete recovery after removal of the agent. Recurrence of hepatic reactions would be expected on re-exposure to CS If the original transaminase Increases were due to CS. [Pg.165]

Serious hepatotoxicity is possibie but rare. Hepatic failure occurs in only one in 40,000 cases and appears to be an idiosyncratic reaction that is not dose-related. Children under the age of 2, especially those receiving anticonvulsant polypharmacy, with mental retardation, and/or with poor nutritional status have been shown to be at greatest risk (351, 352). To our knowledge, no cases of hepatic failure have been reported in adults with bipolar disorder who were receiving VPA monotherapy, but liver failure has been reported in older children and in a mentally retarded adult with epilepsy taking VPA alone ( 77, 352, 353). [Pg.217]

Porubek DJ, Grillo MP, Olsen RK, et al. Toxic metabolites of valproic acid inhibition of rat liver acetoacetyl-CoA thiolase by 2-n-propyl-4-pentenoic acid (A4-VP A) and related branched chain carboxylic acids. In Levy RH, Penry JK, eds. Idiosyncratic Reactions to Valproate Clinical Risk Patterns and Mechanisms of Toxicity. New York Raven Press, 1991 53-58. [Pg.703]

If a patient has cholestasis careful consideration must be given to the use of any drug that can cause biliary problems. Several drugs are known to cause cholestatic hepatitis, including the antibiotics flucloxacillin, erythromycin and co-amoxiclav (amoxicillin/clavulanic acid). Although a patient with cholestasis is no more likely to suffer from this idiosyncratic reaction than a patient without liver impairment, it will be of greater concern if it does occur. [Pg.136]

Terbinafine can cause hepatitis, with an estimated rate of about 1 in 50 000 (34). Idiosyncratic reactions can lead to hver cell necrosis as well as cholestasis. Prolonged cholestatic hepatitis and liver failure have been reported (35-39). [Pg.3317]

Drug-induced liver disease occurs as several different clinical presentations idiosyncratic reactions, allergic hepatitis, toxic hepatitis, chronic active toxic hepatitis, toxic cirrhosis, and liver vascular disorders. [Pg.713]

Centrolobular necrosis is often a dose-related, predictable reaction secondary to drugs such as acetaminophen however, it also can be associated with idiosyncratic reactions, such as those caused by halothane. Also called direct or metabolite-related hepatotoxic-ity, centrolobular necrosis is usually the result of the production of a toxic metabolite (see Fig. 38-1). The damage spreads outward from the middle of a lobe of the liver. [Pg.715]

Halothane is a very widely used anaesthetic drug which may cause hepatic damage in some patients. It seems there are two types of damage, however. One is a very rare, idiosyncratic, reaction resulting in serious liver damage with an incidence of about 1 in 35 000. The other form of hepatotoxicity is a mild liver dysfunction which is more common and occurs in as many as 20% of patients receiving the drug. The two different types probably involve different mechanisms. [Pg.615]

Carbamazepine is metabolized in the liver to carbamtizepine-10, 11-epoxide, an active metabolite that partly contributes to both its anticonvulsant action and neurotoxicity. In contrast to phenytoin. there is u linear increa.se in serum concentration with dosage. Mild neurotoxic effects are common (nau.sea. dizziness, drowsiness, blurred vision and ataxia] and often detemiine the limit of dosage. Agranulocytosis is a rarer idiosyncratic reaction to carbamazepine. [Pg.57]

In 2003, Shenton et al. reported a novel animal model of a drug-induced idiosyncratic reaction nevirapine-induced skin rash in the female Brown Norway rat. This animal model does not reproduce severe skin rashes such as TEN and SJS, nor does it reproduce the liver toxicity observed in some nevirapine-treated patients. However, the skin rash that develops in nevirapine-treated rats closely resembles the mild erythematous rash observed in patients (Shenton et al. 2003). [Pg.441]

Reports of acute liver toxicity associated with consumption of chaparral surfaced from 1990 through 1997, leading to the issuance of a warning by the FDA to cease consumption of chaparral (FDA 1992). The American Herbal Products Association (AHPA) initiated a review of four cases (Watt et al. 1994) and found the reported toxicity to be due to idiosyncratic reactions in persons with preexisting liver conditions. The authors concluded, and AHPA recommended in 1995, that products containing chaparral should be labeled with the following cautionary statement Seek advice from... [Pg.498]

Humberston et al. 2003 Musch et al. 2006 Russmann et al. 2003 Sass et al. 2001 Schmidt et al. 2005 Stoller 2000). These reports have been subject to critical analysis by a number of organizations and individuals (Schmidt 2007 Schmidt et al. 2005 TMEC 2002 Waller 2002). A review of liver toxicity cases indicated that the reported cases represented unpredictable reactions, and that cases were best characterized as idiosyncratic reactions of the metabolic type (Teschke et al. 2008). Of 82 cases of liver toxicity reported through 2002, one case was assessed as being "certain" or "probable" by multiple reviewers, with up to 12 others being noted as "probable" (BfArM 2002 Schmidt 2007)... [Pg.666]

Classification of chemically induced hepatotoxicity is primarily based upon pattern of incidence and histopathological morphology. Intrinsic hepatotoxic drugs demonstrate a broad incidence, dose-response relationship and will usually give similar results in humans and experimental animals. The incidence of liver damage from idiosyncratic hepatotoxicants is limited to susceptible individuals and results from hypersensitivity reactions or unusual metabolic conversions that can occur due to polymorphisms in drug metabolism genes (see Chapters 11 and 13). [Pg.675]

As with any adverse drug reaction, drug-induced liver disease can be described as intrinsic or idiosyncratic. Intrinsic reactions occnr when... [Pg.59]

Comparable reports have prompted a questionnaire investigation of 770 patients with type 2 diabetes at the start of acarbose therapy (51). Patients with one or more susceptibility factors for liver damage underwent ultrasonography and autoantibody assays. There was silent hver disease in 13% and 20 patients had a fatty liver without hepatic disease. In 15% of these patients there were slight reversible changes in transaminase activity after acarbose. This supports the supposition that severe hepatotoxic reactions to acarbose are idiosyncratic. [Pg.88]


See other pages where Liver idiosyncratic reactions is mentioned: [Pg.156]    [Pg.371]    [Pg.399]    [Pg.61]    [Pg.566]    [Pg.869]    [Pg.370]    [Pg.10]    [Pg.568]    [Pg.119]    [Pg.713]    [Pg.238]    [Pg.48]    [Pg.59]    [Pg.483]    [Pg.543]    [Pg.447]    [Pg.911]    [Pg.912]    [Pg.267]    [Pg.623]    [Pg.31]    [Pg.489]    [Pg.363]    [Pg.258]    [Pg.136]    [Pg.554]    [Pg.557]    [Pg.253]    [Pg.544]    [Pg.544]    [Pg.198]   
See also in sourсe #XX -- [ Pg.713 , Pg.714 ]




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Idiosyncratic reactions

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