Drug hepatotoxicity

Larrey, D., Berson, A., Habersetzer, F., Tinel, M., Castot, A., Babany, G., Letteron, P., Freneaux, E. Loeper, J., Dansette, P. and Pessyre, D. (1989) Genetic predisposition to drug hepatotoxicity role in hepatitis caused by amineptine, a tricyclic antidepressant. Hepatology, 10, 168—173. 

Kaplowitz, N. (2005) Idiosyncratic drug hepatotoxicity. Nature Reviews. Drug Discovery, 4 (6), 489 99. 

Boelsterli, U.A. and Lim, P.L. (2007) Mitochondrial abnormalities-a link to idiosyncratic drug hepatotoxicity Toxicology and Applied Pharmacology,... 

Kaplowitz, N. (2006) Rules and laws of drug hepatotoxicity. Pharmacoepidemiology and Drug Safety, 15,231—233. 

Drug hepatotoxicity is a common cause of acute liver failure, with an incidence of 1 in 10 000-100 000. 

Kaplowitz N. Idiosyncratic drug hepatotoxicity. Nat Rev Drug Discov. 2005 4(6) 489-499. 

CosgroveBD, KingBM, Hasan MA, etal. Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity. Toxicol Appl Pharmacol. 2009 237(3) 317-330. 

Chang CY, Schiano TD. Review article Drug hepatotoxicity. Aliment Pharmacol Ther. 2007 25(10) 1135-1151. 

Larrey D, Tinel M, Amouyal G, et al. Genetically determined oxidation polymorphism and drug hepatotoxicity. Study of 51 patients. /Hepatol. 1989 8(2) 158-164. 

Senior JR. Drug Hepatotoxicity from a Regulatory Perspective. Clinics in Liver Disease. 2007 ll(3) 507-524. 

Neuberger J, Kenna JG (1987) Halothane hepatitis a model of immune mediated drug hepatotoxicity. Clin Sci (Lond) 72 263-270... 

Kaplowitz N (2005) Idiosyncratic drug hepatotoxicity. Nat Rev Drug Discov 4 6) 489-499 Kaplowitz N, Aw TY, Ookhtens M (1985) The regulation of hepatic glutathione. Annu Rev Pharmacol Toxicol 25 715-744... 

The liver is a vital organ in the body that plays a primary role in the digestive system in detoxification, protein synthesis, and filtering of blood [56]. Liver-on-a-chip platforms have been developed to understand liver function better and to study drug hepatotoxicity and metabolism [29, 57, 58]. A microfluidic-based device fabricated to mimic the permeable sinusoid endothelial barrier between hepa-tocytes and liver [29] includes three main sections—a central channel to pack the hepatocytes, a microfluidic sinusoid barrier consisting of a set of narrow (2 mm wide) microchannels to model the endothelial barrier, and a convection microfluidic channel surrounding the barrier (Fig. 5A). The flow of nutrients through the convection microfluidic channel feeds the hepatocytes. This system mimics the transportation between blood flow and hepatocytes, and the shear stress over hepatocytes with a patterned set of microchannels. 

BoelsterU UA, Lim PL (2007) Mitochondrial abnormahties—a link to idiosyncratic drug hepatotoxicity Toxicol Appl Pharmacol 220, 92-107. 

Adrenaline hypertension Anticoagulants, oral skin necrosis Antituberculosis drugs hepatotoxicity Pseudoephedrine toxic epidermal necrolysis SSRIs suicidal behavior Statins acute pancreatitis Ximelagatran liver damage... 

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