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Nevirapine-induced skin rash

Shenton, J.M. et al., Characterization of a potential animal model of an idiosyncratic drug reaction Nevirapine-induced skin rash in the rat. Chem. Res. Toxicol., 16, 1078, 2003... [Pg.481]

Chat J, Maimaigudi BM, Xu L, Uetiecht J (2008) Demonstration of the metabolic pathway responsible for nevirapine-induced skin rash. Chem Res Toxicol 21 1862-1870 Claes P, Winizen M, Allard S et al (2004) Nevirapine-induced toxic epidermal necrolysis and toxic hepatitis treated successfully with a combination of intravenous immunoglobulins and N-acetylcysteine. Eur J Intern Med 15 255-258... [Pg.187]

Nevirapine-Induced Skin Rash in Brown Norway Rats... [Pg.202]

Animal Model of Nevirapine-Induced Skin Rash.441... [Pg.437]

In 2003, Shenton et al. reported a novel animal model of a drug-induced idiosyncratic reaction nevirapine-induced skin rash in the female Brown Norway rat. This animal model does not reproduce severe skin rashes such as TEN and SJS, nor does it reproduce the liver toxicity observed in some nevirapine-treated patients. However, the skin rash that develops in nevirapine-treated rats closely resembles the mild erythematous rash observed in patients (Shenton et al. 2003). [Pg.441]

In the skin lesions of both patients and rats with nevirapine-induced skin rash, T cells have been observed. Furthermore, patients with low 04" T cell counts have a significantly lower incidence of rash than those with normal counts, and in rats, partial depletion of these cells also decreases the incidence of skin rash (Shenton et al. 2005). Most drug-induced skin rashes are believed to be immune-mediated and dependence of the rash on CD4 T cells in both humans and rats supports this hypothesis. [Pg.443]

Popovic M, Caswell JL, Mannargudi B, Shenton JM, Uetrecht JP (2006) Study of the sequence of events involved in nevirapine-induced skin rash in Brown Norway rats. Chem Res Toxicol 19(9) 1205-1214... [Pg.452]

Sanne I, Mommeja-Marin H, Hinkle J, Bartlett JA, Lederman MM, Maartens G, Wakeford C, Shaw A, Quinn J, Gish RG, Rousseau F (2005) Severe hepatotoxicity associated with nevirapine use in HIV-infected subjects. J Infect Dis 191 825-829 Shenton JM, Teranishi M, Abu-Asab MS, Yager JA, Uetrecht JP (2003) Characterization of a potential animal model of an idiosyncratic drug reaction nevirapine-induced skin rash in the rat. Chem Res Toxicol 16(9) 1078-1089... [Pg.452]

Chen J, Mannargudi BM, Xu L, Uetrecht J. Demonstration of the metabolic pathway responsible for nevirapine-induced skin rash. Chem Res Toxicol 2008 21(9) 1862-70. [Pg.614]


See other pages where Nevirapine-induced skin rash is mentioned: [Pg.192]    [Pg.221]    [Pg.228]    [Pg.437]    [Pg.437]    [Pg.438]    [Pg.439]    [Pg.441]    [Pg.442]    [Pg.443]    [Pg.448]    [Pg.505]   
See also in sourсe #XX -- [ Pg.202 ]




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