Liriodenine activity

Amorphous residue, inactive3 Yellow solid, liriodenine, active Crystalline residue, michelalbine, inactive3 Amorphous residue, inactive3 Amorphous residue, inactive3 Amorphous residue, inactive3... 

Hufford, C. D., Sharma, A. S. and Oguntimein, B. O. 1980. Antibacterial and antifungal activity of liriodenine and related oxoaporphine alkaloids. Journal of Pharmaceutical Science, 69 1180-1182. 

Liriodenine (70) and other oxoaporphines were evaluated for their antibacterial and antifungal activity against several micro-organisms. Only (70) showed significant activity.78... 

Liriodenine was found to be the mutagenic principle in a methanol extract of the root, root stalk, and stem of Sinomenium acutum (Menispermaceae). The alkaloid exhibited potent mutagenic activity towards Salmonella typhimurium strains TA98 and TA100 in the presence of liver homogenate (S9 mix)(10.9 and 90.7 revertants/nmol, respectively), and accounted for about 40% of the mutagenicity of the total methanol extract. The mutagenic potency of liriodenine is comparable to that of benzo[a]pyrene [295]. 

Liriodenine was found to be active in the brine shrimp lethality test (LC50 2.03 pg/ml) but was inactive in the 9PS (a chemically-induced murine lymphocytic leukemia) and 9KB (human nasopharyngeal carcinoma) cytotoxicity tests [296],... 

A series of fifty-three isoquinoline alkaloids were tested for cytotoxicity against A-549 (human lung carcinoma), HCT-8 (human colon carcinoma), KB, P-388, and L-1210 cells in vitro. Liriodenine showed potent and wide spectrum activity against all five cell lines tested A-549 (EDJ0 0.72 pg/ml), HCT-8 (0.70), KB (1.00), P-388 (0.57), and L-121-0 (2.33)[299]. 

Mutagenecity to Salmonella typhimurium TA 100 and TA 98 in the presence or absence of S9 mix was tested for forty-four isoquinoline alkaloids [111]. Liriodenine was the most active oxoaporphine while lysicamine was the least active. Based on the absence of mutagenicity of l,2,10-trimethoxy-7-oxoaporphine, the authors concluded that substitution at position 10 of the 7-oxoaporphine system cancelled the mutagenicity. 

Liriodenine (1) has significant in vitro inhibitory activity against the... 

Cardiovascular Activity-. Vasorelaxation can be induced by liriodenine (A-59) [60,61], isocorydine (A-29) [41], coclaurin (A-2) [58], A-methyl co claurine (A-3) [58], atherosperminine (A-89) [58] and A-methylatherosperminium (A-91) [58]. Liriodenine was also found to have many bioactivities including antiarrythmic efficacy [62] and antimuscamic activity [60,61]. Antimicrobial activity was displayed by phenanthrenes, benzylisoquinolines and apoiphines [63]. (-)-Discretamine (A-15) was examined as an antagonist of a-adrenoceptor, OiD-adrenoceptor and 5-HT receptors [64,65]. Trachealis relaxation was induced by atherospermidine (A-61) [65]. 

Staphylococcus aureus, Mycobacterium smegmatis, and Candida albicans. Davis also stated that (-)anonaine (39) can employ a hypotensive effect in mice and rabbits and was shown to be an inhibitor of dopaminergic response. Also, the toxicity of anonaine HCl was demonstrated in mice at 200 rng kg. A related compound, liriodenine (40), had similar antibacterial activity to anonaine. Liriodenine exhibited fairly potent cytotoxic and cytopathic effects against Herpes simplex virus type 1 (HSV-1) [64], Furthermore, the methylenedioxy functionality of this molecule is beleived to be involved in the observed activity [64], Liriodenine has been isolated from the stem bark of several Magnolia spp. such as M. campbelii, M. mutabilis [24] and the trunk bark of M watsonii and M. obovata [57],... 

Liriodenine (1,2-methylenedioxyoxoaporphine) is a broad-spectrum antimicrobial agent, active against gram-positive bacteria and yeast-like and filamentous fungi.Liriodenine methiodide is also active, and both compounds may be potentially useful as antibiotics. 

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