Liriodenine

That compounds of the potency of liriodenine are present in plant tissues underscores the potential of plants to affect dramatically other organisms in their environment. Release of liriodenine or similarly potent agents from decomposing plant materials may significantly modify the microbial flora of the root zone. This in turn may have direct and indirect effect the plants which will germinate and grow in the affected soil, the classical allelopathlc effect (11). 

Amorphous residue, inactive3 Yellow solid, liriodenine, active Crystalline residue, michelalbine, inactive3 Amorphous residue, inactive3 Amorphous residue, inactive3 Amorphous residue, inactive3... 

The potential properties of A. suaveolens Bl. has a source of topoisomerase II inhibitor is open for exploration. The plant probably elaborates aporphine alkaloids because aporphines are known to occur in the genus Artabotrys (2,3), Liriodenine and athero-spermidine from Artabotrys undnatus and artabotrine from Artabotrys zeylanicus abrogated the survival of cancer cells cultured in vitro (4). 

In the Philippines, the sap expressed from the stem is drunk to alleviate headache. Using antiplatelet aggregation as a guide to fractionation, Chen et al. isolated a series of aporphines including actinodaphnine, N-methylactinodaphnine, launobine, dicentrine, O-methylbulbocapnine, hernovine, bulbocapnine, and oxoaporphines dicentrinone and liriodenine were isolated from the stems of I. luzonensis (13). 

Sung HW, Reynolds MC, Nan JS, Cassady JM, Snapka RM. Inhibition of topoiso-merase II by liriodenine. Biochem Pharmacol 1997 54 467-473. 

Hufford, C. D., Sharma, A. S. and Oguntimein, B. O. 1980. Antibacterial and antifungal activity of liriodenine and related oxoaporphine alkaloids. Journal of Pharmaceutical Science, 69 1180-1182. 

Nelumbium nuciferum Gaertner N. speclosum Willd. Lian, He Ye (East Indian lotus) (leaf) Nuciferine, roemerine, anonaine, O-nornuciferine, liriodenine, anneparine, dihydronuciferine, pronuciferine, N-methylcoclaurine, N-methylisococlaurine.33 Relaxing effect on smooth muscles, increase essential body energies. 

Alternatively, reduction of the keto-imine (20) with sodium borohydride gave a mixture of two carbinols corresponding to N-demethylated (16) and (17). Irradiation of this mixture produced norushinsunine together with a little noroliveroline. Photolysis of the alcohol (21) gave rise to the oxoaporphine liriodenine (22).21 Synthetic routes to those aporphines that incorporate a hydroxyl group at C-7 that is trans to the proton at C-6a are already known.22 23 A novel synthesis of aporphines via 3-phenylphenethylamines has been developed, and is described in Scheme 1. The aporphine (23) and related species were then synthesized by a modified route.24... 

Following the isolation of liriodenine and oxolaureline from the bark of Laurelia novae-zelandiae, a careful n.m.r. analysis has revealed that H-ll of oxoaporphines does not necessarily absorb downfield from H-8.50... 

Ocotea minarum contains the known oxoaporphines dicentrinone and thalic-minine.4 Liriodenine is present in Rhigiocarya racemifera15 and in Pachygone ovata9b and lanuginosine is found in Anona squamosa.19... 

Kmeria duperreana (Pierre) Dandy (stem Magnoliaceae Liriodenine (26)... 

Michelia rajaniana Craib. (stem bark) Magnoliaceae Liriodenine (37)... 

The other known alkaloids that have been isolated from S. venosa include (-)-crebanine, dehydrocrebanine, oxocrebanine, oxostepha-nine, liriodenine, (-)-anonaine, (-)-asimilobine, (-)-nuciferoline, (-)-apoglaziovine, (-)-tuduranine, (-)-mecambroline, (-)-stesakine, (-)-ushinsunine, and (-)-4a-hydroxycrebanine. The two major alkaloids found are the known norproaporphine, ( + )-stepharine, and the aporphine (-)-crebanine (28-32). 

Liriodenine (l,2-methylenedioxy-7-oxodibenzoquinoline) was found to act in vitro upon cells of human nasopharyngeal carcinoma (436, 437). 

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