Lipidosis

Systemic Rat (Fischer- 344) 20, 40, 60 d 1 x/d (G) Endocr 1700 (bilaterally enlarged adrenal glands, lipidosis in adrenal cortex of 18/18, vacuolization of cortex cytoplasm) Latendresse et al. 1994a BTP... 

F (lipidosis in ovarian interstitial cells of 8/8, ovarian interstitial cell hypertrophy)... 

Familial demyelinative/dysmyelinative and axonal neuropathies may also be caused by impaired lysosomal lipid metabolism. Metachromatic leukodystrophy (sulfatide lipidosis) results from mutations of the arylsulfatase A gene, which encodes a lysosomal enzyme required for sulfatide turnover. Myelin is affected in both CNS and PNS, though dysfunction is restricted to the PNS in some patients, and the onset of symptoms can occur at any time between infancy and adulthood. Bone marrow transplantation can slow disease progression and improve nerve conduction velocities [57]. (See in Ch. 41.)... 

Upcn hydrogenation, fish oils, especially the longer chain fatty acids (C22 s), form many new positional and geometric isomers. In some cases, partially hydrogenated fish oils may contain as many as 50% of the docosenoic acids in the trans form as opposed to the naturally occurring cis form. It is these trans isomers which may be responsible for the lipidosis of heart and skeletal muscle found in monkeys. Epidemiological studies of populations with high intakes of docosenoic acids. 

Brady RO, Barranger JA Glucosylceramide lipidosis Gaucher s disease, in Stanbury JB, Wyngaar-den JB, Frederickson DS, et al. (eds) The Metabolic Basis of Inherited Disease. McGraw-Hill, New York, 1983, pp. 842-56... 

Brady, R.O., O Neill, R.R., and Barton, N.W. (1993). Glucosylceramide lipidosis Gaucher s disease. In The Molecular and Genetic Basis of Neurological Disease. R.N.Rosenberg, S.B.Pruisner, S.DiMauro, R.L.Barchi, and L.M.Kunkel, eds. (Boston Bntterworth-Heinemann), pp. 467 484. 

Fredrickson, D.S. (1979). Gaucher s disease (glucosyl ceramide lipidosis). In Cecil Textbook of Medicine. P.B.Beeson, W.McDermott, and J.B.Wyngaarden, eds. (London W.B.Saunders), pp. 2012 2014. 

A primary lipidosis has been described in human optic nerves affected by amiodarone. One study has shown that intracytoplasmic inclusions may mechanically or biochemically block axoplasmic flow in large optic nerve axons, resulting in optic disc edema and hemorrhage. 

Morelli JK, Buehrle M, Pognan F, et al. Validation of an in vitro screen for phospho-lipidosis using a high-content biology platform. Cell Biol Toxicol. 2006 22(l) 15-27. 

Latendresse, J.R., S. Azhar, C.L. Brooks and C.C. Capen. Pathogenesis of cholesteryl lipidosis of adrenocortical and ovarian interstitial cells in F344 rats caused by tricresyl phosphate and butylated triphenyl phosphate. Toxicol. Appl. Pharmacol. 122 281-289, 1993. 

R587 Z, Xia, G. Ying, A. L. Hansson, H. Karlsson, Y, Xie, A. Bergstrand, J. W. DePierre and L. Nassberger, Antidepressant-Induced Lipidosis with Special Reference to Tricyclic Compounds , Prog. Neurobiol. (Oxford). 2000, 60, 501... 

Gaucher s disease (glucosyl ceramide lipidosis three types see text)... 

Lipides, 238, 239, 241-243, 261 Lipidosis, 239, 242, 243 Lobry de Bruyn-Alberda van Ekenstein transformation, 63, 291 acid catalysis of, 79 aldolization in, 77 base catalysis of, 79-81 catalysis of, by metal ions, 81 dealdolization in, 77 dehydration reactions in, 73 enzyme-catalyzed, 66, 70 formation of reductones in, 79 of or-hydroxy aldehydes, 71 mechanism of, 84 of noncarbohydrate a-ketols, 71 non-enzymic, 66, 67, 83 in paper chromatography, 81 rearrangement of carbon chain, 79 scope of, 65 of steroids, 72 use of, for synthesis, 82 Lyxonic acid, 3-deoxy-D-, 300 Lyxose, D-, condensation of, with urea, 218... 

Tomizawa, K., Sugano, K., Yamada, H., Hori, I. (2006). Physicochemical and cell-based approach for early screening of phospho-lipidosis-inducing potential. The Journal of Toxicological Sciences, 31, 315-324. 

Xia, Z., E-L. Appelkvist, J. W. Depierre, and L. Nassberger. 1997. Tricyclic antidepressant-induced lipidosis in human monocytes in vitro as well as monocyte derived cell line, as monitored by spectrofluorimetry and flow cytometry after staining with Nile red. Biochemical Pharmacology 53 1521-1532. 

W19. Wolfe, L. S., Callahan, J., Andermann, F., Scriver, C. R., Fawcett, J. S., and Plnsky, L., Systemic late infantile lipidosis Beta-galactosidase deficiency with cerebral GMi gangliosidosis and accumulation and excretion of a keratan sulfate. Neurology 19, 305 (1969). 

Hadjiisky, P Hermier, D TrufiFert, J., De Gennes, J.-L Grosgogeat, Y. (1993). Effect of pravastatin, a HMG CoA reductase inhibitor, on blood lipids and aortic lipidosis in cholesterol-fed White Cameau pigeons. BiochirtL Biophys. Acta, 1181, 279-86. 

The effect of tricyclic antidepressants (TCA) on phospholipid bilayer structure and dynamics was studied to provide insight into the mechanism of TCA-induced intracellular accumulation of lipids (known as lipidosis). Solid state P and " N NMR techniques were used. Changes in bilayer architecture in the presence of TCAs were observed to be dependent on the TCA s effective charge and steric constraints. 

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