Level in rat tissues

Chen LC, Berberian I, Koch B, et al. 1992. Polychlorinated and polybrominated biphenyl congners and retinol levels in rat tissues Structural-activity relationships. Toxicol Appl Pharmacol 114(l) 47-55. 

Table III summarizes the total radioactive residues (TRR) in comparable tissues of all three species dosed at approximately the same rate. Radiocarbon levels in rat tissues were low and reflected the potential effect of a 7-day depuration period. Goat and hen tissue residues were consistently higher due to the effect of a multiple dose regimen and a depuration interval of less than 24 hours.

Manganese Levels in Rat Tissue after Oral Exposure... 

Yokoi K, Kimuha M and Itokawa Y (1994) Effect of low — rubidium diet on macro — mineral levels in rat tissues. J Jpn Soc Nutr Food Sci 50 295-299. 

The determination of metaUothionein levels in rat tissues by a radiochemical method using 110 Ag and Hg as tracers was elaborated . In all organs the n Ag saturation procedure gave lower results than the Hg procedure, and the latter also showed low specificity so should not be used for determining low levels of metaUothioneins. The Hg... 

Table IV. Effects of Butylated Hydroxytoluene (BHT), N,N -Diphenyl-P-Phenylenediamine (DPPD), Vitamin E, Ascorbic Acid, and Selenium on liercury Levels in Rat Tissues... 

Inhibition of monoamine oxidase has been proposed as a possible mechanism underlying the hydrogen sulfide-mediated disruption of neurotransmission in brain stem nuclei controlling respiration (Warenycia et al. 1989a). Administration of sodium hydrosulfide, an alkali salt of hydrogen sulfide, has been shown to increase brain catecholamine and serotonin levels in rats. It has also been suggested that persulfide formation resulting from sulfide interaction with tissue cystine and cystinyl peptides may underlie some... 

ACC2 selective inhibitors exemplified by 16 (ACC1 IC50 > 30 gM, ACC2 IC50 38 nM) have also been reported and were shown to reduce malonyl CoA levels in muscle tissues of Sprague-Dawley rats [51]. Although ACC inhibitors have... 

As can be seen from the results in Table V, fluoride levels in plasma, liver and kidney increased 3 to 8 times but there was no significant effect on the calcium or phosphorus content, although the kidney Ca level in fluoride treated rats was 40 higher than in the controls. Whereas the normal exposure to fluoride from air, food and water did not cause any increase in soft tissue levels, more than ten times the normal levels in soft tissues, including liver and kidney, were found in human fatalities due to fluoride poisoning (15). 

SPCA1 is a housekeeping enzyme and is therefore expressed in all cells (Vanoevelen et al., 2005). Results on the relative expression level in various tissues are still conflicting. Expression levels, both at the mRNA and at the protein level, in rat brain and testis were much higher than in other tissues like lung and liver (Wootton et al., 2004). Such relatively high expression in brain and testis was not observed at the mRNA level in humans (Vanoevelen et al., 2005). The cell-type dependent expression of SPCA1 in various animal species thus deserves further study. 

Paradisi L, Panagini C, Negro F, et al. 1984. Behavior of cyclic nucleotides and Ca2+ levels in liver tissue of rats poisoned by white phosphorus and trichlorobromomethane. Cell Biochem Funct 2 111-114. 

D5. Du Ruisseau, J. P., Greenstein, J. P., Winitz, M., and Birnbaum, S., Free amino acid levels in the tissues of rats protected against ammonia toxicity. Arch. Biochem. Biophys. 68, 161 (1957). 

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