Leukemia-associated protein

Saha, V., et al., The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AFIO, and MLLT6 proteins. Proc Natl Acad Sci USA, 1995, 92(21), 9737-41. 

Li M, Makkinje A, Damuni Z (1996) The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A. J Biol Chem 271 11059-11062... 

Hayashi Y (2000) The molecular genetics of recurring chromosome abnormalities in acute myeloid leukemia [In Process Citation]. Semin Hematol 37 368-380 Heery DM, Kalkhoven E, Hoare S, Parker MG (1997) A signature motif in transcriptional co-activators mediates binding to nuclear receptors [see comments]. Nature 387 733-736 Ida K, Kitabayashi I, Taki T, Taniwaki M, Noro K, Yamamoto M, Ohki M, Hayashi Y (1997) Adenoviral E 1 A-associated protein p300 is involved in acute myeloid leukemia with t(ll 22)(q23 ql3). Blood 90 4699-4704... 

Lin, W.J., Gary J.D., Yang, M.C., Clarke, S. and Herschman, H.R. (1996) The mammalian immediate-early TIS21 protein and the leukemia-associated BTGl protein interact with a protein-arginine N-methyltransferase. The Journal of Biological Chemistry, 271, 15034—15044. 

Fukuhara, S., Chikumi, H., and Gutkind, J. S. (2000). Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G (12) family to Rho. FEBS Lett. 485, 183-188. 

Reuther, G. W., Lambert, Q. T., Booden, M. A., Wennerberg, K., Becknell, B., Marcucci, J., Sondek, J., Caligiuri, M. A., and Der, C. J. (2001). Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA. /. Biol. Chem. 276, 27145-27151. 

The oxidized metabolites of benzene, including reactive benzene oxide intermediate, are known to bind with DNA, RNA, and proteins. This can result in cell destruction, alteration of cell growth, and inhibition of enzymes involved in the processes of forming blood cells. This phenomenon is probably responsible for the bone marrow damage, aplastic anemia (lowered production of blood cells due to damage to bone marrow), and, in severe cases, leukemia associated with benzene exposure. 

PHOSPHORYLA TWN chronic myelongenous leukemia-associated KIO BCR-ABL Drosophila Kr protein hepatitis B virus core and precore antigens human c-fos protein human c-myc protein human EGF receptor human epidermal growth factor receptor (tyrosine kinase domain) human immunodeficiency virus p24 human immunodeficiency virus tat protein human insulin receptor 6-subunit human insulin receptor - tyrosine kinase domain... 

A13. Azar, H. A., Hill, W. T., and Osserman, E. F., Malignant lymphoma and lymphatic leukemia associated with myeloma-type serum proteins. Amer. J. Med. 23, 239-249 (1957). 

This pair of granule-associated proteins is also localized to cytotoxic T and NK cells. They are essential for both apoptosis and induced cell death of target cells via induction of perforated cell membranes. However, their expression is assumed to be evidence of an activated state. They mark subcutaneous panniculitis-like T-cell lymphoma, aggressive NK-cell leukemia, and extra-nodal NK/T cell lymphoma, nasal type. 

These leukemias may express the cytotoxic granule-associated protein TIA-1, which is normally found in natural killer cells and cytotoxic T lymphocytes regardless of their state of activation. The tumor cells are commonly EBV infected. 

Abl tyrosine kinase <1> (present in 95% of patients with chronic myelogenous leukemia, CML [39]) [39] adhesion-related kinase agammaglobulinaemia tyrosine kinase amylovoran biosynthesis membrane-associated protein amsA anaplastic lymphoma kinase B ceU progenitor kinase B lymphocyte kinase B-cell/myeloid kinase BCR-ABL tyrosine kinase BMK BPK... 

ABC, ATP-binding cassette AML, acute mylogenous leukemia NSCLC, non-small-cell lung cancer NSAIDs, non-steroidal anti-inflammatory drugs BCRP, breast cancer resistance protein MDRl, multidrug resistance 1 MRP, multidrug resistance-associated proteins P-gp, P-glycoprotein. 

Ito E, Honma R, Imai J, Azuma S, Kanno T, Mori S, Yoshie O, Nishio J, Iwasaki H, Yoshida K, Gohda J, Inoue J, Watanabe S, Semba K. A tetraspanin-family protein, T-cell acut lymphoblastic leukemia-associated antigen 1, is induced by the Ewing s sarcoma-Wilms mmor 1 fusion protein of desmoplastic small round cell tumor. Am J Pathol. 2003 163 2165-72. 

By analogy, one could speculate that ECRF3 sensitizes T cells to CXC chemokines to regulate proliferation of virally infected cells. In this regard, it is important to recall that HVS causes fatal T-cell lymphomas and leukemias when introduced into nonnatural primate hosts. Whereas other HVS ORFs, including STP, which encodes the saimiri transformation-associated protein, are known to be necessary for HVS transforming... 

Druker B et al (1992) Tyrosine phosphorylation of rasGAP and associated proteins in chronic myelogenous leukemia cell lines. Blood 79 2215-2220... 

David G, Alland L, Hong S-H, Wong C-W, DePinho R, Dejean A (1998) Histone deacetylase associated with mSin3A mediates repression by the promyelocytic leukemia-associated PLZF protein. Oncogene 16 2549-2556... 

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