Lanolin cream

This is an antioxidant in topical preparations. Roed-Petersen and Hjorth (1976) reported six cases of contact allergy with a lanolin cream containing nordihidro-guaiaretic acid (NDGA) as the culprit in three cases. 

Glyceryl palmitate lactate creams, barrier Dimethicone creams, cosmetics Zirconium silicate creams, face Lanolin creams, hand Dimethylsiloxane creams, o/w... 

Amerchol L 101, 50% petrolatum, product containing lanolin alcohols obtained by hydrolysis of lanolin (creams and ointments)... 

Ointments and Creams Ointments are applied to the skin for topical treatment or to be absorbed into the blood system for delivery to target areas. They are semisofid preparations obtained by mixing the API with selected ointment bases depending on intended use. These bases include petrolatum, paraffin, mineral oil, lanolin, and glycols. Preservatives are often added to ensure the ointments will maintain the recommended shelf life. 

The lanolin extracted from the wool is purified further for use in cosmetics, hand cream, boot-polish, and so on. Part of the permeate from the ultrafiltration is recycled to save fresh water. A particular advantage arises from the fact that the dissolved sweat components exhibit... 

The unsaponifiables of woolwax, known as woolwax alcohols, are in considerable demand by cosmetic and pharmaceutical industries. Woolwax has a great affinity for water, of which it will absorb 25 to 30%. Refined woolwax is kneaded with water to produce a water-white, colorless oiiilmenL, known as hydrous lanolin or lanolin USP. Anhydrous lanolin is widely used in cosmetic creams, since it is readily absorbed by the skin. It is also used m leather dressings and shoe pastes, as a superfatting agent for toilet soap, as a protective coating for metals, etc. United States consumption of wool wax is about 1.5 million lb/year. 

Ointments are similar to creams but may be more viscous. Many ointments are prepared from a base of anhydrous lanolin or white petrolatum, which is a mixture ofn-, iso-, and cyclic-paraffins. Waxes may be added to make the ointments harder. 

FIGURE 25.1 Lanolin alcohol (Eucerit , Beiersdorf AG, Hamburg, Germany) reduces skin roughness, as measured by microprofilometry. Lanolin alcohol (2 and 4%, w/w LA) in a water-in-oil cream containing petrolatum was applied twice daily to the volar aspect of the arm. (Adapted from Sauermann, G. and Schreiner, V., The Lanolin Book, Beiersdorf AG, Hamburg, 1999. With permission.)... 

Water-in-oil emulsions traditionally contain surfactants of natural origin such as cholesterol, wool fat, wool alcohols, lanolin, divalent salts of fatty acids soaps, calcium oleate and/or synthetic agents of low hydrophilic-lipophilic balance (HLB) (indicating high lipophilicity), such as Spans (fatty acid esters of sorbi-tan). An example of such a product is Oily Cream B.P. which consists of a 1 1 mixture of wool alcohols and water. 

Lanolin may be used as a hydrophobic vehicle and in the preparation of water-in-oil creams and ointments. When mixed with suitable vegetable oils or with soft paraffin, it produces emollient creams that penetrate the skin and hence facilitate the absorption of drugs. Lanolin mixes with about twice its own weight of water, without separation, to produce stable emulsions that do not readily become rancid on storage. 

Lanolin alcohols is used in topical pharmaceutical formulations and cosmetics as a hydrophobic vehicle with emollient properties, e.g., in preparations for dry skin and dry eyes. It is also used in the preparation of water-in-oil creams and ointments at concentrations as low as 2% w/w. The proportion of water that can be incorporated into petrolatum is increased threefold hy the addition of 5% lanolin alcohols. Such emulsions do not crack upon the addition of citric, lactic, or tartaric acids. 

Hydrous lanolin is commonly used in the preparation of water-in-oil creams and ointments. More water may be incorporated into hydrous lanolin than into lanolin. 

Mineral oil and lanolin alcohols is an oily liquid used in topical pharmaceutical formulations and cosmetics as an emulsifying agent with emollient properties see Table I. It is used as a primary emulsifier in the preparation of water-in-oil creams and lotions and as an auxiliary emulsifier and stabilizing agent in oil-in-water creams and lotions. 

Prosperio G, Gatti S, Genesi P. Lanolin and its derivatives for cosmetic creams and lotions. Cosmet Toilet 1980 95(4) 81-85. 

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