Kikuchi disease

Cervical lymphadenopathy, fever, and a maculopapular skin rash developed in a 17-year-old boy after he had taken carbamazepine for 3 weeks (up to 600 mg/day) (66). Lymph node biopsies showed features typical of Kikuchi disease, a rare and self-limited immune-mediated lymphadenopathy that affects mostly the cervical region. The condition cleared rapidly after withdrawal. 

Ganga A, Corda D, Gallo Carrabba G, Cossu S, MassareUi G, Rosati G. A case of carbamazepine-induced lymphadenopathy resembling Kikuchi disease. Eur Neurol 1998 39(4) 247-8. 

Cells in Kikuchi disease are true histiocytes negative for B- and T-cell markers, positive for CD68 and MAC387. 

Nagura J, Iso H, Watanabe Y, Maruyama K, Date C, Toyoshima H, Yamamoto A, Kikuchi S, Koizumi A, Kondo T, Wada Y, Inaba Y and Tamakoshi A. 2009. Fruit, vegetable and bean intake and mortality from cardiovascular disease among Japanese men and women the JACC Study. Br J Nutr 13 1—8. 

Kuriyama S, Shimazu T, Ohmori K, Kikuchi N, Nakaya N, Nishino Y, Tsubono Y and Tsuji I. 2006. Green tea consumption and mortality due to cardiovascular disease, cancer, and all causes in Japan the Ohsaki study. JAMA 296 1255-1265. 

H3. Hayashi, J. L., Ohta, S., Kikuchi, A., Takemitsu, M., Goto, Y. I., and Nonaka, I., Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction. Proc. Natl. Acad. Sci. USA 88, 10614-10618 (1991). 

Niino M, Ogata A, Kikuchi S, Tashiro K, Nisliihira J (2000) Macrophage migi adon inliibitory factor in die cerebrospinal fluid of padents widi convendonal and opdc-spinal forms of muldple sclerosis and neuro-Behcet s disease. J Neurol Sci 179 127—131. 

M. Gotoh, S. Nagase, K. Aoyagi, A. Hirayama, K. Takemura, A. Ueda, C. Tomida, H. Kikuchi, A. Koyama, Thiobarbituric Acid Reactive Substances are Increased in the Subcutaneous Fat Tissue of Patients with End-Stage Renal Disease, Nephrology Dialysis Transplantation 12(4) (1997) 713-717. 

Yamazaki H, Ikeda H, Ishizu A, Nakamaru Y, Sugaya T, Kikuchi K, Yamada S, Wakisaka A, Kasai N, Koike T, Hatanaka M, Yoshiki T (1997) A wide spectrum of collagen vascular and autoimmune diseases in transgenic rats carrying the env-pX gene of human T lymphocyte virus type I. Int Immunol 9 339-346. 

Yoshiki T, Dceda H, Tomaru U, Ohya O, Kasai T, Yamashita I, Morita K, Yamazaki H, Ishizu A, Nakamaru Y, Kikuchi K, Tanaka S, Wakisaka A (1997) Models of HTLV-I-induced diseases. Infectious transmission of HTLV-I in inbred rats and HTVL-I env-pX transgenic rats. Leukemia 1 l(Suppl 3) 245-246. 

Shi N, Kawano Y, Tateishi T, Kikuchi H, Osoegawa M, Ohyagi Y, Kira JI (2006) Increased IL-13-producing T cells in ALS Positive correlations with disease severity and progression rate. J Neuroimmunol 182 232-235. 

Wang Y, Kikuchi S, Suzuki H, Nagase S, Koyama A. Endothelial nitric oxide synthase gene polymorphism in intron 4 affects the progression of renal failure in non-diabetic renal disease. Nephrol Dial Transplant 1999 14(12) 2898-2902. 

Dennison BA, Kikuchi DA, Srinivasan SR, Webber LS, Berenson GS. Parental history of cardiovascular disease as an indication for screening for lipoprotein abnormalities in children. J Pediatr 1989 115 ... 

Holmberg L. A. Kikuchi K. Gooley T. et al. Gastrointestinal graft versus host disease in recipients of autologous hematopoietic stem cells incidence, risk factors and outcome. Biol of Blood Marrow Transol 2006.12,226-234. 

Yufu Y, Matsumoto M, Miyamura T, et al. Parvovirus B19-associated haemophagocytic syndrome with lymphadenopathy resembling histiocytic necrotizing lymphadenitis (Kikuchi s disease). Br J Haematol. 1997 96 868-871. 

Ohshima K, Kikuchi M, Shibata T, et al. Clonal analysis of Hodgkin s disease shows absence of TCR/Ig gene rearrangement, compared with T-cell-rich B-cell lymphoma and incipient adult T-cell leukemia/lymphoma. Leuk Lymphoma. 1994 15 469-479. 

Spies J, Foucar K, Thompson CT, et al. The histopathology of cutaneous lesions of Kikuchi s disease (necrotizing lymphadenitis) a report of five cases. Am J Surg Pathol. 1999 23 1040-1047. 

Yen HR, Lin PY, Chuang WY, et al. Skin manifestations of Kikuchi-Fujimoto disease case report and review. Eur J Pediatr. 2004 163 210-213. 

Kuo TT. Kikuchi s disease (histiocytic necrotizing lymphadenitis) a clinicopathologic study of 79 cases with an analysis of histologic subtypes, immunohistology, and DNA ploidy. Am J Surg Pathol. 1995 19 798-809. 

WATANABE, S., UESUGI, S., KIKUCHI, Y., Isoflavones for prevention of cancer, cardiovascular diseases, gynecological problems and possible immune potentiation, Biomed. Pharmacother., 2002, 56, 302-312. 

Miyagishi, R., Kikuchi, S., Fukazawa, T., and Tashiro, K. (1995). Macrophage inflammatory protein-1 alpha in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological diseases. J. Neurol. Sci. 129, 223-227. 

Fractalkine is reported to be involved in the pathogenesis of renal diseases like glomerulonephritis (Cockwell et al., 2002) and nephropathy in Streptozotocin-induced diabetic rats (Kikuchi et al., 2004). Involvement of fractalkine is also shown in cardiac allograft rejection (Robinson et al., 2000), and the inhibition of lymphotactin expression by cyclosporine A and FK506 suggests that this chemokine contributes to allograft rejection. 

Cui, R.Z., Moriyama, Y., Koike, K.A., Date, C., Kikuchi, S., Tamakoshi, A., and Iso, H., 2008. Serum total homocysteine concentrations and risk of mortality from stroke and coronary heart disease in Japanese the JACC study. Atherosclerosis. 198 412-418. 

Eshak, E.S Iso, H Date, C Kikuchi, S Watanabe, Y Wada, Y. Dietary fiber intake is associated with reduced risk of mortality from cardiovascular disease among Japanese men and women. Journal ofNutrition, v. 140, n. 14, p. 45-53, 2010. 

Oliver SJ, Kikuchi T, Krueger JG, et al. Thalidomide induces granuloma differentiation in sarcoid skin lesions associated with disease improvement. Clin Immunol 2002 102 225-236. 

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