Key determining

The key determinants of future cost competitiveness of a-Si H PV technology are a-Si H deposition rates, module production yields, stabilized module efficiencies, production volume, and module design. Reported a-Si H deposition rates vary by more than a factor of 10, but most researchers report that the high quaUty films necessary for high stabilized efficiencies require low deposition rates often due to high hydrogen dhution of the Si (and Ge) source gases (see Semiconductors, amorphous). 

Products. In all of the instances in which crystallization is used to carry out a specific function, product requirements are a central component in determining the ultimate success of the process. These requirements grow out of how the product is to be used and the processing steps between crystallization and recovery of the final product. Key determinants of product quaHty are the size distribution (including mean and spread), the morphology (including habit or shape and form), and purity. Of these, only the last is important with other separation processes. 

These meteorological parameters, with the possible exception of the mean wind speed and direction, are not generally available for inclusion in calculations. Even wind speed measurements, which are usually taken at 20 ft above grade, must be corrected to the release point elevation. The correction applied to the wind speed depends on the turbulence of the air. The wind speed is the key determinant of the convection of pollutant in a plume. 

As this example illustrates, there is no single right answer. The key determinant must be your judgment as to the most effective allocation of resources (time and energy) against the goal of improving overall safety performance. 

Land use is the other key determinant of transit use. Public transit requires a concentration of trips in the same time and place. A concentration of residential and commercial land use, such as that typically... 

Alike any other G-protein coupled receptors (GPCRs), mGlu receptors have seven transmembrane helices, also known as the heptahelical domain (Fig. 2). As observed for all GPCRs, the intracellular loops 2 and 3 as well as the C-terminal tail are the key determinants for the interaction with and activation of G-proteins. However, sequence similarity analysis as well as specific structural features make these mGlu receptors different from many other... 

One study used quality-adjusted life years to capture the range of health-related dimensions that may affect the quality of life of patients. This measure also provides an estimate of the value or preferences for changes in health status (Neumann et al, 1999). The study used the Health Utility Index Mark II in a sample of patients and carers, which is a generic measure of the value of health-related quality of life. However, it is clear that further research is needed to explore (a) the key determinants or dimensions of quality of life that are important to people with dementia and their carers (b) whether existing instmments to measure and value health-related quality of life are able to detect differences in quality of life that are important to people with cognitive disability and their carers and (c) whether the assessment and... 

Seah SYK, G Labbe, S Nerdinger, M Johnson, V Snieckus, LD Eltis (2000) Identification of a serine hydrolase as a key determinant in the microbial degradation of polychlorinated biphenyls. J Biol Chem 275 15701-15708. 

The importance of including soil-based parameters in rhizosphere simulations has been emphasized (56). Scott et al. u.sed a time-dependent exudation boundary condition and a layer model to predict how introduced bacteria would colonize the root environment from a seed-based inoculum. They explicitly included pore size distribution and matric potential as determinants of microbial growth rate and diffusion potential. Their simulations showed that the total number of bacteria in the rhizosphere and their vertical colonization were sensitive to the matric potential of the soil. Soil structure and pore size distribution was also predicted to be a key determinant of the competitive success of a genetically modified microorganism introduced into soil (57). The Scott (56) model also demonstrated that the diffusive movement of root exudates was an important factor in determining microbial abundance. Results from models that ignore the spatial nature of the rhizosphere and treat exudate concentration as a spatially averaged parameter (14) should therefore be treated with some caution. 

Previous hospitalization or health care utilization (Also a key determinant in selecting therapy because the patient may be at risk for specific pathogens and/or resistant pathogens)... 

Tardif MR, Tremblay MJ. LFA-1 is a key determinant for preferential infection of memory CD4+ T cells by human immunodeficiency virus type 1. J Virol 2005 79(21) 13714-13724. 

As noted earlier, perhaps the key determinant of the overall release characteristics from an osmotic pump system is the solubility of the drug. If the solubility of the drug is too low, then the total dose that can be delivered is limited. If the solubility is too high, then the percent of the total dose that can be delivered at a zero-order rate can be relatively small. For example, as shown by Theeuwes [10], the fraction of the total dose (F) that can be delivered at a zero-order rate is given by... 

The extent to which the drug can overcome the barriers to its oral delivery is measured by the term oral bioavailability , and this is one of the key determinants of compound quality as it is an indication of the ability of that drug to overcome the barriers to its delivery. 

The volume is divided into five sections. Part one looks at the experimental study of membrane permeability and oral absorption. In Part two, problems of measuring and prediction solubility, as one of the key determinants in the absorption process, will be discussed in detail. In the next part, progress in the science around transporter proteins and gut wall metabolism and their effect on the overall absorption process is presented. Part four looks at the in silico approaches and models to predict permeability, absorption and bioavailability. In the last part of the book, a number of drug development issues will be highlighted, which could have an important impact of the overall delivery strategies for oral pharmaceutical products. 

NESI, N., JOND, C., DEBEAUJON, I., CABOCHE, M., LEPINIEC, L., The Arabidopsis TT2 gene encodes an R2R3 MYB domain protein that acts as a key determinant for accumulation in developing seed, Plant Cell, 2001,13,2099-2114. 

Paine MJ, McLaughlin LA, Flanagan JU, et al. Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6. J Biol Chem 2003 278(6) 4021-4027. 

This chapter examines an issue that is one of the key determinants of the future of the West European chlor-alkali industry. It examines the environmental, economic, financial and political aspects of a debate whose effects are likely to spill over into North America and Asia - and to affect the development of the chlor-alkali industry world-wide. 

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