Jaspis sponges

A two sponge association of a thin crust of Haliclona sp. overlaying an unidentified choristid (probably not Jaspis) sponge contained two enol sulfates, presumed to be from the choristid sponge [437]. These enol sulfates were also found as the sodium salts jaspisin (520) [438] and isojaspisin (521) [439] and ( )- and (Z)-narains (522-523) [440] from... 

Jaspamide (17), previously mentioned in Section 17.3, is a modified peptide isolated from a Jaspis sponge. Jaspamide shows insecticidal activity against Heliothis virescens with an LCS0 of 4 ppm, as compared to 1 ppm for azadirachtin. Jaspamide (17), showed more than 72% mortality at 100 ppm to both southern com rootworm and tobacco budworm. Iso-domoic acids A (40), B, and C are novel amino acids from the red alga Chondria armata. They... 

In contrast, jasplakinolide, a cyclodepsipeptide from the marine sponge Jaspis johnstoni, rapidly penetrates the cell membrane. It competes with phalloidin for F-actin binding and has a dissociation constant of approximately 15 nM. It induces actin polymerization and stabilizes pre-existing actin filaments. Dolastatin 11, a depsipeptide from the mollusk Dolabella auricu-laria, induces F-actin polymerization. Its binding site differs from that of phalloidin or jasplakinolide. 

Kobayashi, J. Yuasa, K. Kobayashi, T. Tsuda, M. Sasaki, T. (1996A) Jaspifo ls A-G, new cytotoxic isomalabaricane-type nortriterpenoids from Okinawan marine sponge Jaspis stellifera. Tetrahedron, 52, 5745-50. 

Triterpenoids are a minor group of sponge metabolites of these malabaricane/isomalabaricane triterpenoids, Fig. (21) are known from Jaspis and Stelletla sponge species. All of this group shows cytotoxicity and anti-HIV activity [136-139]. 

Aminoacids occur in plants and animals, both in the free state and as the basic units of proteins and other metabolites. Aminoacid derivatives have been reported in marine environment, such as from marine sponges of the genus Jaspis sp. [371,372], from Suberea creba, a Coral Sea marine sponge [373], and the marine ascidian Leptoclinides dubius [374], Some of these compounds have been shown to possess interesting biological properties, e g., cytostatic activity exhibited by axinastatin-4, an aminoacid derivative isolated from a marine sponge [375],... 

Following the first report of tumor promotion by okadaic acid, additional tumor promoters of the okadaic acid activity class have been identified, e.g., microcystin [513,514], and calyculin derivatives, Fig. (63) reported in marine sponges such as Discodermia calyx [515] and Theonella swinhoei [516] as potent inhibitors of tumor cell proliferation. A two-sponge association, Poecillastra sp. and Jaspis sp., yielded cytotoxic toxins which exhibited selective activity against several tumoral cell lines [517],... 

Zampella A, Giannini C, Debitus C, Roussakis C, D Auria MV (1999) New Jaspamide Derivatives from the Marine Sponge Jaspis splendans Collected in Vanuatu. J Nat Prod 62 332... 

From sponges of the genus Jaspis collected at Fiji (300,301), Palau (300), and Papua New Guinea (302), jaspamide (jasplakinolide, 372) was isolated the compound shows potent insecticidal, antifungal, anthelminthic, and ichthyotoxic activity. The structure was determined by X-ray analysis (300). The solution conformation of372 was reported using NMR, molecular mechanics, and dynamics calculations (303). A complexation study was carried out with 372 and the univalent metal ions Li ", Na+, and K+. Li+ binding was observed, and the complex was characterized by NMR and molecular mechanics calculations (304). Jaspamide (372) has potent in... 

Tsukamoto, S., Kato, H., Hirota, H., and Fusetani, N., V,V-Dimcthylgiianidiiim styryl sulfates, metamorphosis inducers of ascidian larvae from a marine sponge Jaspis sp., Tetrahedron Lett., 35, 5873, 1994. 

Actin Jasplakinolide (Structure 16.1) Sponge, Jaspis sp. Anticancer12... 

Bengamides were isolated originally as anthelmintic agents from a sponge Jaspis sp. Later, bengamide A (36) was found to inhibit growth of tumor cells as well as methionine aminopep-tidases (2). 

There are few examples of natural 2-phenylnaphthalene derivatives. To our knowledge, the one natural 2-phenylnaphthalene derivative has been isolated from the Marine Sponge Jaspis sp. [12]. The authors postulated a biosynthesis from 3,4-dihydroxyphenylethanal, but C6-C3 derivatives, i.e., DOPA or 3,4-dihydroxyphenyllactic acid cannot be rejected considering the above discussion. 

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