Ichthyotoxic activity

Halistanol sulfate (532) from Halichondria cf. moorei is a tris-sodium sulfate salt, which possesses antimicrobial, hemolytic, and ichthyotoxic activity [444]. It was later isolated from two sponges of the genus Topsentia as the free sterol and found to inhibit pp60v-src protein tyrosine kinase activity [445]. The tris(2-aminoimidazolium) salt of halistanol sulfate (533) was isolated from Topsentia sp. from Japan and is also antimicrobial [446]. 

Umbraculumin C (90), characterized by the presence of a trans-3-(methylthio)-acrylic acyl residue, is a diacylglycerol obtained from the skin of the opisthobranch mollusc Umbraculum mediterraneum [96]. Taylor and co-workers determined the absolute configuration of 90 by total synthesis [97] while Sodano et al. reached the same conclusion by derivatisation of the natural compound [98]. Compound 90 displayed ichthyotoxic activity against the mosquito fish at 0.1 pg/ml and should represent the deterrent of this organism against predators [96]. 

From sponges of the genus Jaspis collected at Fiji (300,301), Palau (300), and Papua New Guinea (302), jaspamide (jasplakinolide, 372) was isolated the compound shows potent insecticidal, antifungal, anthelminthic, and ichthyotoxic activity. The structure was determined by X-ray analysis (300). The solution conformation of372 was reported using NMR, molecular mechanics, and dynamics calculations (303). A complexation study was carried out with 372 and the univalent metal ions Li ", Na+, and K+. Li+ binding was observed, and the complex was characterized by NMR and molecular mechanics calculations (304). Jaspamide (372) has potent in... 

Deeds, J.R. et al, Hemolytic and ichthyotoxic activity from cultures of Karlodinium micrum (Dinophyceae) associated with fish mortalities in an estuarine aquaculture facility, Harmful Algae 1, 169, 2002. 

Key word index -- Cardioveiscular activity, pseudoginsenoside-RTi, Randia siamensis, saponins, uterine contractility, ichthyotoxic activity. 

Ichthyotoxic Activity of Alcohol Extract The fish used in this experiment are Puntius gonionotus Smith, Poecilia reticulata Peters, Cyprinus carpio Linn, and Tilapia nilotica Linn. The ichthyotoxic activity of the alcoholic extract was performed by following the method of Sprague (Sprague, 1969, 1971). 

Resveratrol (3,4, 5-stilbenetriol) is a phytoalexin from the roots of Veratrum grandiflorum and the bark of Pi-nus sibirica, it also occurs in Eucalyptus, Polygonum, Nothofagus, and other species. The resveratrol contained in red wine (see wine, phenolic constituents oO is supposed to be beneficial for health. In animal experiments, resveratrol inhibits monoamine oxidase A (MAO-A) Dihydroresveratrol (a,/S-dihydro-3,4, 5-stilbenetriol) and its 3-methyl ether are constituents of Cannabis sativa the latter shows estrogenic activity. Piceatannol (3,3, 4,5 -stilbenetetrol, astringenin) (E)-form needles, is isolated from spruce trees, it is fiin-gitoxic, inhibits plant growth, and has ichthyotoxic activity. 

Sarcophyton spp. Terpenoids (diterpene) Sarcotol sarcotol acetate and sarcotal acetate m Ichthyotoxic activity against Japanese killifish Oryzias latipes [71]... 

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