Leptoclinides dubius

Aminoacids occur in plants and animals, both in the free state and as the basic units of proteins and other metabolites. Aminoacid derivatives have been reported in marine environment, such as from marine sponges of the genus Jaspis sp. [371,372], from Suberea creba, a Coral Sea marine sponge [373], and the marine ascidian Leptoclinides dubius [374], Some of these compounds have been shown to possess interesting biological properties, e g., cytostatic activity exhibited by axinastatin-4, an aminoacid derivative isolated from a marine sponge [375],... 

Garcia A, Vazquez MG, Quifloa E, Riguera R, Debitus C (1996) New Amino Acid Derivatives from the Marine Ascidian Leptoclinides dubius. J Nat Prod 59 782... 

Garcia, A., Vasquez, M. J., Quino4 E., Riguera, R, Debitus, C., (1996). New amino acid derivatives from the marine ascidian Leptoclinides dubius. J. Nat. Prod. 59, 782-785. 

A series of cytotoxic dipeptides formed from rare amino acids derived from guanidine has been isolated from a polar extrad of the New Caledonian species Leptoclinides dubius (Garda et al, 1996). 

According to Brand et al. (1989), a few species of aplousobranch ascidians, such as Eudistoma amplus, Euherdmania sp., Leptoclinides dubius and L lissus, also contain vanadium in their blood cells. 

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