Jaspis johnstoni

In contrast, jasplakinolide, a cyclodepsipeptide from the marine sponge Jaspis johnstoni, rapidly penetrates the cell membrane. It competes with phalloidin for F-actin binding and has a dissociation constant of approximately 15 nM. It induces actin polymerization and stabilizes pre-existing actin filaments. Dolastatin 11, a depsipeptide from the mollusk Dolabella auricu-laria, induces F-actin polymerization. Its binding site differs from that of phalloidin or jasplakinolide. 

Zabriskie, T. M. and Ireland, C. M., The isolation and structure of modified bioactive nucleosides from Jaspis johnstoni, J. Nat. Prod., 52, 1353, 1989. 

In one of the few studies of marine fungi, the novel chloriolins A-C (e.g. the structure of chloriolin B, 157) have been reported from a cultured, unidentified fungus associated with the sponge Jaspis johnstoni [185],... 

C,3H,6N406 324.293 Isol. from the sponge Jaspis johnstoni. Cytotoxic agent. Cryst. (MeOH/CHCL). Sol. MeOH, CHCI3 poorly sol. hexane. Mp 216-218°. X,nax 211 232 (sh) 281 (MeOH). 

Previously identified and new sesquiterpenoids were isolated from an unidentified fungus obtained from an Indo-Pacific sponge Jaspis aff. Johnstoni [103,104]. The mycelium gave coriolin B (76 extraction yield 3.8 mg/1) and dihydrocoriolin C (77 extraction yield 3.7 mg/1), which were previously reported from the terrestrial basidiomycete Coriolus consors. The broth gave chloriolin A (78 a white crystal extraction yield 4 mg/1), chloriolin B (79 a white solid extraction yield 3.5 mg/ml) and chloriolin C (80 a white solid extraction yield 0.6 mg/ml). The structure of these three new chlorinated compounds was determined by NMR experiments, synthetic transformations and X-ray crystallography. 

Three chlorinated derivatives, chloriolins A-C, were isolated from cultures of an unidentified fimgus harvested from the sponge Jaspis cf johnstoni. Chloriolins B and C are sesquiterpene esters which have the tricyclic skeleton of hirsutane, of which chloriolin A is a degraded bicyclic form (Cheng et al, 1994). 

Murray, L.M., Johnson, A., and Crews, P. (1997) Geographic variation in the tropical marine sponge Jaspis cf johnstoni an unexpected source of new terpene-benzenoids. J. Org. Chem., 62, 5638-5643. 

Murayama, T., Ohizumi, Y, Nakamura, H., Sasaki, T., and Kobayashi, J. (1989) Plakortin, a potent Ca" "" " ATPase activator from the Okinawan marine sponge Plakortis sp. Experientia, 45,898-899. Murray, L.M., Johnson, A., and Crews, P. (1997) Geographic variation in the tropical marine sponge Jaspis c johnstoni an imexpected source of new terpene-benzenoids. /. Oig. Chem., 62, 5638-5643. Myers, B.L. and Crews, P. (1983) Chiral ether glycerides from a marine sponge./. Org. Chem., 48, 3583-3585. 

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