Irritation testing inhalation routes

Studies on test animals indicate that methylene bis(4-cyclohexylisocyanate) is highly toxic by an inhalation route and can cause severe skin reaction. Exposure to 20 ppm for 5 hours produced irritation of the respiratory tract, tremor, convulsion, congestion of lungs, and edema in rats. The symptoms at lower levels were decreased as to respiration rate and pulmonary irritation. 

Moderately toxic in test animals via inhalation route exposure to 18 ppm (140 mg/m ) for 2 hr was fatal to mice following respiratory tract irritation and lung injury no report on human toxicity... 

Hepatic Effects. Liver function tests (serum bilirubin, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyl transferase) completed in 11 hexachloroethane workers were within the normal range (Selden et al. 1994). Plasma hexachloroethane levels in these workers, who wore protective equipment, were 7.3 + 6.04 pg/L at the time of the tests (Selden et al. 1993). Mild skin and mucous membrane irritation were reported in the exposed group, suggesting that exposure may have been through either the inhalation or dermal routes of exposure. 

Flammable Liquid SAFETY PROFILE Poison by intraperitoneal route. Moderately toxic by intravenous and subcutaneous routes. Mildly toxic by inhalation. An experimental teratogen. Human systemic effects by inhalation CNS recording changes, hallucinations or distorted perceptions, motor activity changes, antipsychotic, psychophysiological test changes, and bone marrow changes. Experimental reproductive effects. Mutation data reported. A human eye irritant. An experimental skin and severe eye irritant. 

The subchronic toxicity of EGBE has been examined in animals via oral, inhalation, and dermal routes of exposure. The lowest no-observed-effect level (NOEL) in an oral subchronic study was 80 mg kg for rats administered EGBE in feed over a 90 day period. Inhalation exposure of rats for 13 weeks, 6h day , 5 days week to EGBE vapors at 25-77 ppm indicated an NOEL of 25 ppm. In a 90 day dermal study of rabbits, EGBE was applied 6 h day, 5 days week at doses up to 150 mg kg There was no evidence of systemic toxicity or skin irritation at the site of application at any of the dose levels tested. 

The toxicity data on pyrrole are scant. It is moderately toxic on test animals. The routes of exposure are inhalation of vapors, ingestion, and skin absorption. Vapors are an irritant to the eyes and respiratory tract. The lethal doses in rabbits by oral and dermal routes are within the range 150 and 250 mg/kg, respectively. 

Severe eye irritant can cause skin burns irritant action and toxicity lower than ethylenimine moderately toxic by all routes of exposure inhalation of 500 ppm for 4 hr was lethal to rats tested positive to histidine reversion — Ames test for mutagenicity produced tumors in blood, brain, and skin in animals A2 — suspected human carcinogen TLV-TWA sMn 2 ppm ( 5 mg/m ) (ACGIH, MSHA, and OSHA), IDLH 500 ppm (NIOSH) ... 

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