Invasion prostate cancer

Locally invasive prostate cancer is associated with ureteral dysfunction or impingement, such as alterations in micturition (e.g., urinary frequency, hesitancy, dribbling). 

In countries such as Japan, although the incidence of latent, small or non-infiltrative prostate cancer is similar to that found in Western countries, the incidence of invasive cancer and associated mortality is far lower (Adlercreutz and Mazur, 1997). In Japan, diets have traditionally included large amounts of soy, and it has been proposed that this may be responsible for the protective effect. To date, however, the results are inconsistent, although there may be an inverse correlation with non-fermented soy foods. The active component... 

Singh S, Singh UP, Stiles JK, Grizzle WE, Lillard JW Jr. Expression and functional role of CCR9 in prostate cancer cell migration and invasion. Clin Cancer Res 2004 10 8743-8750. 

Another focus has been on the invasiveness of prostate cancer cells since prostate cancer lethality is tied to metastatic processes. Metastatic cells have acquired the ability to invade basement... 

Woodson, K, J Gillespie, J Hanson, M Emmert-Buck, JM Phillips et al. 2004. Heterogeneous gene methyla-tion patterns among pre-invasive and cancerous lesions of the prostate a histopathologic study of whole mount prostate specimens. Prostate 60(1) 25-31. 

Armicotte, J.S., lankova, 1., Miard, S., Fritz, V., Sarruf, D., Abella, A., Berthe, M.L., Noel, D., Pillon, A., Iborra, F., Dubus, P., Maudelonde, T., Culine, S. and Fajas, L. (2006) Peroxisome proliferator-activated receptor gamma regulates E-cadherin expression and inhibits growth and invasion of prostate cancer. Molecular and Cellular Biology, 26, 7561-7574. 

HarmaV,VirtanenJ,MakelaRetal(2010)A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses. PLoS One 5 el0431... 

Fluorouracil is used in several combination regimens in the treatment of breast cancer. It also has palliative activity in gastrointestinal adenocarcinomas, including those originating in the stomach, pancreas, liver, colon, and rectum. Other tumors in which some antitumor effects have been reported include carcinomas of the ovary, cervix, oropharynx, bladder, and prostate. Topical 5-fluorouracil cream has been useful in the treatment of premalignant keratoses of the skin and superficial basal cell carcinomas, but it should not be used in invasive skin cancer. 

Hong JH, Aim KS, Bae E, Jeon SS, Choi HY. 2006. The effects of curcumin on the invasiveness of prostate cancer in vitro and in vivo. Prostate Cancer Prostatic Dis 9 147-152. 

Retinol, carotenoids, and tocopherol and risk of prostate cancer. J. Natl. Cancer Inst. 82,941-946. Ignatoski, K.M., Maehama, T., Markwart, S.M., Dixon, J.E., Livant, D.L., and Ethier, S.P. 2000. ERBB-2 overexpression confers PI 3 kinase-dependent invasion capacity on human mammary epithelial cells. Br. J. Cancer 82, 666-674. 

B16. Burfeind, P., Chemicky, C. L., Rininsland, F., Ilan, J., Ilan J., Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor invasion by rat prostate cancer cells in vivo. Proc. Natl. Acad. Sci. (USA) 93, 7263-7268 (1996). 

Santibanez, J. F., Navarro, A., and Martinez, J., Genistein inhibits proliferation and in vitro invasive potential of human prostatic cancer cell lines. Anticancer Res. 17, 1199—1204 (1997). 

Schwartz, G. G., Wang, M. H., Zang, M., Singh, R. K., and Siegel, G. P., la,25-Dihydroxivitamin D (calcitriol) inhibits the invasiveness of human prostate cancer cells. Cancer Epidemiol. Biomarkers Prev. 6, 727-732 (1997). 

T11. Tserotas, K., and Merino, G., Andropause and the ageing male. Arch. Andr. 40, 87-93 (1998). T12. Turner, T., Epps-Fung, M. V., Kassis, J., and Wells, A., Molecular inhibition of phospholipase c y signalling abrogates DU-145 prostate tumor cell invasion. Clin. Cancer Res. 3, 2275-2282... 

Virtanen, S.S., Vaananen, H.K., Harkonen, P.L., and Lakkakorpi, P.T. (2002). Alendronate inhibits invasion of PC-3 prostate cancer cells by affecting the mevalonate pathway. Cancer Res 62 2708-2714. 

Bonaccorsi L, Muratori M, Carloni V et aL Androgen receptor and prostate cancer invasion. Int J Androl 2003 26(l) 21-25. 

Treating prostate cancer in its early stage should be an effective means of achieving long-term survival. However, the non-invasive diagnostic tests currently available, i.e. digital rectal examination, transrectal ultrasound, and... 

Genistein and daidzein directly affect testosterone metabolism, reducing the toxic metabolites of testosterone. Genistein, an isoflavone, also seems to slow or prevent the metastasis of invasive cancer cells. It is believed to work by preventing the formation of new blood vessels to cancerous tumors. Histoculture studies of genistein have shown that this phytochemical reduces the growth of prostatic cancer tissue. 

Nithipatikom K, Endsley MP, Isbell MA, Wheelock CE, Hammock BD, Campbell WB (2005) A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells. Biochem Biophys Res Commun 332 1028-1033... 

Whereas prostatic carcinoma may be asymptomatic in patients with localized disease, most patients with signs and symptoms have advanced disease at presentation. In patients with locally invasive disease, the most common complaints arise from ureteral dysfunction or impingement. Patients complain of alterations in micturition manifested by urinary frequency, hesitancy, and dribbling.New onset impotence or less firm penile erections in an elderly male may indicate prostate cancer. 

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