Intoxication symptoms

Post-intoxication symptoms The symptomatology after 2x LD50 soman followed by a post-intoxication therapy of animals pretreated with PYR was comparable with no pretreatment (see Fig. 1). Pretreatment with PHY+SCO improved the signs compared with PYR This was mainly found on severe symptoms. On the other hand, animals pretreated with PHY+PC did not show any worse symptoms as was found in the other groups. In some cases the post-intoxication therapy was not necessary because no symptoms were present. 

Drug Class Drug Potential Intoxication Symptoms Consequences of Use ... 

Sympathomimetics can be physically addictive and should not be prescribed to people with a history of drug abuse. A person may develop a tolerance to the drug and attempt to increase the dosage. The person may develop intoxication symptoms such as insomnia and severe skin diseases. 

However, most public concern does not center around death or other acute intoxication symptoms, but rather those chronic injuries which we term as irreversible. These are carcinogenesis (cancer), teratogenesis (birth defects), or mutagenesis (genetic defects). There have been three good studies involving the ability of 2,4-D to cause cancer. The conclusion by the authors of these three studies is that there is no evidence that 2,4-D causes cancer. However, the study design was such that they were not adequate to prove that 2,4-D could not cause cancer, and as a result, further cancer studies were required by the EPA which should provide a definitive answer. 

In acute intoxication, symptoms develop progressively, typically beginning with persistent vomiting and diarrhea (mucous and blood, with a bluish-green color). Shortly after the onset of the gastrointestinal symptoms, in some cases even earlier, a rash appears (with macules and/or papules), beginning on the abdomen, genitalia. 

Reports Number of cases Treatment before Intoxication Symptoms described... 

The literature on the toxicity of benzene in humans is extensive. The acute effects of benzene exposure generally differ markedly from the chronic effects. Acute exposure to high doses of benzene in air (at concentrations in excess of 3000 ppm) causes symptoms typical of organic solvent intoxication. Symptoms may progress from excitation, euphoria, headache, and vertigo, in mild cases, to central nervous system depression, confusion, seizures, coma, and death from respiratory failure in severe cases. The rate of recovery depends on the initial exposure time and concentration, but, following severe intoxication, the symptoms may persist for weeks. 

Inhalants cause fast acting intoxicating symptoms because they are inhaled directly into the lungs. The initial symptom is stimulation but with repeated... 

The onset of intoxication symptoms is dependent on the pathway of absorption within a few minutes of inhalation, from 15 min to 1 h after swallowing, and 2-3 h after cutaneous resorption, a toxic concentration will be reached in the blood. With indirect acetylcholinesterase inhibitors, e.g. parathion, symptoms of poisoning occur later. No exact data exist about the extent of bioavaUability in the human body. 

The authors investigated the possible relationship between poisoning due to ingestion of H. rutilans and DHO-DH inhibiton by 3, and concluded that the intoxication symptoms are due to the high content of polyporic acid. 

The signs of OPC intoxication can develop either immediately or several hours later after the exposure. The intoxication symptoms can develop slowly and sustain for several days in case of more lipophilic compounds that require metabolic activation. The clinical picture of acute OPC intoxication includes muscarine-like and nicotine-like disorders, changes on side of the central nervous system and respiration. Depending upon the substance structure, metabolism rate and direction as well as the evidence of one or another disorder on side of the central nervous system can change. 

Enzyme regeneration is 105 times faster than it is with 2HN-OH alone. Under actual poisoning conditions treatment includes 2-PAM as well as heroic doses of atropine (up to 50 mg in 24 hours) to counteract the muscarinic intoxication symptoms. Intravenous barbiturates to stop convulsions may also be utilized. 

In [ninciple, this is assessed by incidence rate fw chronic intoxication for highly exposed workers. If the incidence rate for chronic intoxication is not available, the incidence rate of intoxication symptoms or signs can be used. 

Although the general toxicity of Ge is low, exposure to germanium can lead to intoxication symptoms in flora, fauna, and humans. Ge products (elixirs, supplements) present a potential human health hazard (Tao and Bolger 1997). 

Thallium, which may give rise to lead intoxication symptoms, would give a positive lead test with this procedure. 

Chronic intoxication. Symptoms correlate poorly with serum levels, and the Done Nomogram cannot be used to predict toxicity. Chronic therapeutic concentrations in arthritis patients range from 100 to 300 mg/L (10-30 mg/dL). A level greater than 600 mg/L (60 mg/dL) accompanied by acidosis and altered mental status is considered very serious. 

These observations are compatible with the assessments (see above) that cannabinoids, although they are not associated with one unique type of behavior, produce a characteristic pattern of effects on the central nervous system. Moreover, both discriminative stimulus effects of various cannabinoids and marijuana-intoxication symptoms in humans were found to highly correlate with CBi receptor binding. Consequently it was suggested that the rat model of drug discrimination may be used to predict cannabinoid intoxication in humans (19). 

Toxicobgy LD50 (oral, rat) 1410 mg/kg, (skin, rabbit) 3560 mg/kg toxic may cause mild skin and severe eye irritation skin absorp. can occur inh. of mist may cause nose/throat irritation, headaches, nausea, dizziness, drowsiness, incoordination ing. may cause alcohol intoxication symptoms severe exposure may cause unconsciousness, coma may cause lung damage, respiratory arrest, death if aspirated into... 

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