Interleukin tumor angiogenesis

Cytokines such as interferons are used for the treatment of hepatitis, cancer, and lymphoma interleukins are used to enhance immune response and growth factors are used for the treatment of anemia and regulation of tumor angiogenesis. 

Y10. Yuan, A., Yang, P. C., Yu, C. J., Chen, W. J., Lin, F. Y., Kuo, S. H., andLuh, K. T., Interleukin-8 messenger ribonucleic acid expression correlates with tumor progression, tumor angiogenesis, patient survival, and timing of relapse in non-small-cell lung cancer. Am. J. Respir. Crit. Care Med. 162, 1957-1963 (2000). 

Brat DJ, Bellail AC, Van Meir EG (2005) The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro-Oncol 7 122-133... 

Majewski S, Marczak M, Szmurlo A, et al. Interleukin-12 inhibits angiogenesis induced by human tumor cell fines in vivo. J Invest Dermatol 1996 106 ni4-8. 

Crowther M, Brown NJ, Bishop ET, Lewis CE Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors. J Leukoc Biol 2001 70 478-490. Kelly RW, Illingworth P, Baldie G, Leask R, Brouwer S, Calder AA Progesterone control of interleukin-8 production in endometrium and chorio-decidual cells underlines the role of the neutrophil in menstruation and parturition. Hum Reprod 1994 9 253-258. 

Merkel cell carcinoma, and human lung squamous cell carcinoma cell hues in cultures. The tumor-prevention and anticancer activities of aloe are due mostly to the immune stimulation and immune modulation through activation of macrophages (antigens), causing the release of substances like interferons, interleukines, and tumor necrosis factor. A/oe vera gel inhibited angiogenesis, a process of forming new blood vessels to feed the tumor. It also potentiated the effects of 5-fluorouracil and cyclophosphamide in combination therapy. ... 

Smith DR, Polverini PJ, Kunkel SL, et al. Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma. J Exp Med 1994 179 1409-1415. Richmond A, Thomas H. Melanoma growth stimulatory activity isolation from human melanoma tumors and characterization of tissue distribution. J Biol Chem 1988 36 185-198. 

Coughlin CM, Salhany KE, Wysocka M, et al. Interleukin-12 and interleukin-18 synergisticaUy induce murine tumor regression which involves inhibition of angiogenesis. J Clin Invest 1998 101 1441-1452. 

Yoshida S, Ono M, Shono T, et al. Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis. Mol Cell Biol 1997 17 4015 -4023. 

Huang, S., Mills, L., Mian, B., Tellez, C., McCarty, M., Yang, X. D., Gudas, J. M., and Bar-Eli, M. (2002). Fully humanized neutralizing antibodies to interleukin-8 (ABX-IL8) inhibit angiogenesis, tumor growth, and metastasis of human melanoma. Am. J. Pathol. 161, 125-134. 

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