Interleukin-lb

Epps, P.E. et al. (1992) Spectral characterization of environment-sensitive adducts of interleukin lb. J. Biol. Chem. 267, 3129. 

Welsh, N., and Sandler, S. (1992). Interleukin-lb induces nitric oxide prodution and inhibits the activity of aconitase without decreasing glucose oxidation rates in isolated mouse pancreatic islets. Biochem. Biophys. Res. Commun. 182, 333-340. 

Selegiline stimulates the biosynthesis of interleukin-lb and interleukin-6, is an immu-noenhancing substance, possesses antiapoptotic action, and is a neuroprotectant. 

Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-lb-converting enzyme. Cell 1993 75 641-652. 

Zoja C, Wang JM, Bettoni S, Sironi M, Renzi D, Chiaffarino F, Abboud HE, Van Damme J, Mantovani A, Remuzzi G, Rambaldi A. Interleukin-lb and tumor necrosis factor-a induce gene expression and production of leukocyte chemotactic factors, colony-stimulating factors, and interleukin-6 in human mesangial cells. Am J Pathol 1991 138 991-1003. 

Rivera, S., Gold, S.J. and Gall, C.M. (1994) Interleukin-lb increases basic fibroblast growth factor mRNA expression in adult rat brain and organotypic hippocampal cultures. Mol. Brain Res. 27 12-26. 

Metal ions released from metal implants by osteoclastic bio-corrosion are distributed through- out the body and are eventually taken up by dendritic cells, the most potent anti-gen-presenting cells [14, 15, 18]. Besides changing phenotypic and functional properties of dendritic cells [18], metal ions complex with cellular proteins and peptides. In case of titanium, the ions form complexes with phosphorus-containing proteins and peptides (usually signaling molecules), nucleotides (DNA in the nuclease and RNA in the cytoplasm) and lipids (phospholipids of the cellular membranes) [15]. The new antigenic metal-peptides are presented by dendritic cells to specific T-lymphocytes that react and are activated [15]. The dendritic cells and activated T-lymphocytes accumulate in tissues with high metal concentrations, usually close to the metal implant, and form inflammatory reactions [7] that include secretion of inflammatory cytokines, such as TNF-a, TGF-b, interleukin-6 and interleukin-lb [19]. Most important is secretion of RANK-L by the activated T-lymphocytes, an essential factor for maturation, survival and function of osteoclasts [19]. 

Martinez-Cacenes EM (1998) Amelioration of flu-like symptoms at the onset of interferon beta-lb therapy in multiple sclerosis by low dose oral steroids is related to a decrease in interleukin-6 mduc-tion. Arm Neurol 44(4) 682-685. 

Gillio AP, Faulkner LB, Alter BP, Reilly L, Klafter R, Heller G, Young DC, Lipton JM, Moore MA, O Reilly RJ. Treatment of Diamond-Blackfan anemia with recombinant human interleukin-3. Blood 1993 82(3) 744-51. 

The interferon beta-la form (Avonex ) is similarly a immunomodulator used by injection in the treatment of multiple sclerosis. Interferons derived through recombinant DNA technology are labelled (rbe). interferon beta — interferon p. interferon beta-la interferon p. interferon beta-lb interferon p. interferon P2 interleukin 6. interferon yOFN-y MAF immune interferon interferon gamma [ban, inn] formerly called immune interferon Polyferon ) can be isolated from immunologically stimulated T-lymphocytes (hence its former name), and is an IMMUNOMODULAIOR that can be used to treat arthritis and shows activity as an ANTICANCER AGENT. 

Tamura M, Arakaki N, Tsubouchi H, Takada H, Daikuhara Y (1993) Enhancement of human hepatocyte growth factor production by interleukin-1 alpha and -1 beta and tumor necrosis factor-alpha by fibroblasts in culture. J Biol Chem 268 8140-8145 Tee LB, Boobis AR, Huggett AC, Davies DS (1986) Reversal of acetaminophen toxicity in isolated hamster hepatocytes by dithiothreitol. Toxicol Appl Pharmacol 83 294—314... 

Nanney LB, Mueller SG, Bueno R, Peiper SC, Richmond A. Distributions of melanoma growth stimulatory activity or growth-related gene and the interleukin-8 receptor type B in human wound repair. Ann J Pathol 1995 147 1248-1260. 

Kasahara, K., Stricter, R. M., Standiford, T. J., and Kunkel, S. L. (1993) Adherence in combination with lipopolysaccharide, tumor necrosis factor or inierleukin-lb potentiates the induction of monocyte-derived interleukin-8. Pathobiol. 61,57-66. 

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