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Interferons Alcohol

Interferons are contraindicated in individuals with autoimmune hepatitis or other autoimmune disease, uncontrolled thyroid disease, severe cardiac disease, severe renal or hepatic impairment, seizure disorders, and CNS dysfunction. Immunosuppressed transplant recipients should not receive interferons. Interferons should be used with caution in persons who have myelosuppression or who are taking myelosuppressive drugs. Preparations containing benzyl alcohol are associated with neurotoxicity, organ failure, and death in neonates and infants and therefore are contraindicated in this population. Interferons should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. [Pg.579]

Rolls, J. R., Lei, D., Stoltz, D., Zhang, P., Schwarzenberger, P. O., Ye, P., Bagby, G., Summer, W. R., Shellito, J. E. andNelson, S. (1998). Adenoviral-mediated interferon-gamma gene therapy augments pulmonary host defense of ethanol-treated rats. Alcohol Clin. Exp. Res. 22, 157-162. [Pg.98]

Interferon alfa-2a formulations contain excipients sodium chloride, polysorbate, ammonium acetate, and benzyl alcohol as a preservative. Interferon alfa is also approved for use in the treatment of several other disorders. [Pg.333]

The occurrence of psychiatric disorders has been prospectively investigated in 63 patients who received a 6-month course of interferon alfa (9 MU/week) for hepatitis C (379). All were assessed at baseline with the Structured Clinical Interview for DSM-III-R (SCID) and monitored monthly with the Hopkins Symptoms Checklist (SCL-90). Most had a history of alcohol or polysubstance dependence, and 12 had a lifetime diagnosis of major depression. There were no significant changes in the SCL-90 scores during the 6-month period of survey in the 49 patients who completed the study, even in those who had a lifetime history of major depression. At 6 months, there was probable minor depression in eight patients and major depression in one none had attempted suicide. [Pg.675]

Decompensated hepatic disease (e.g., active alcoholism, ascites, coagulopathy, hypoalbuminemia, or jaundice) should not be treated with PEG-interferon a-2b... [Pg.93]

Immobilied Cibacron Blue 3G-A has been found very efficient for the isolation of human serum albumin interferons produced in tissue cultures phosphogly-cerate kinase from Saccharomyces cerevisiae and alcohol dehydrogenase from equine liver. Immobilized Procion Red HE-3B and Prcxaon Blue MX-4GD have been successfully applied for the isolation of 3-hydroxybutyrate and malate dehydrogenases... [Pg.217]

Haemosiderosis can be found in several chronic liver diseases, such as chronic hepatitis (especially HVC leading to a reduced response rate to a-interferon), late-stage cirrhosis, spontaneous or surgical portal-systemic shunts, and non-alcoholic steatohepatitis. [Pg.627]

Even moderate but continuing alcohol consumption needs to be taken seriously in patients receiving interferon alfa, and exacerbation of previous acute alcohol hepatitis has been reported in two patients with chronic hepatitis C, despite reduced alcohol consumption (403). Liver transaminases subsequently normalized after withdrawal of interferon alfa in both patients. [Pg.1817]

Zylberberg H, Fontaine H, Thepot V, Nalpas B, Brechot C, Fol S. Triggering of acute alcoholic hepatitis by alpha-interferon therapy. J Hepatol 1999 30(4) 722-5. [Pg.1830]

Each milliliter contains 3 MIL of interferon alpha-2a, recombinant, 7.21 mg of sodium chloride, 0.2 mg of polysorbate 80, 10 mg of benzyl alcohol as a preservative, and 0.77 mg of ammonium acetate. [Pg.342]

Drugs Alcohol, estrogens, isotretinoin, beta blockers, glucocorticoids, bile-acid resins, thiazides asparaginase, interferons, azole antifungals, mirtazapine, anabolic steroids, sirolimus, bexarotene Malnutrition Malabsorption Myeloproliferative diseases Chronic infectiousdiseases AIDS, tuberculosis Monoclonal gammopathy Chronic liver disease Malnutrition Obesity... [Pg.435]

Interferon alfa-2b vials Multidose 18 million IU (0.088 mg) 0.024mg/ mL (22.8 million IU/ 3.8 mL) or (3 million IU/0.5mL) isopropyl alcohol, w-butyl alcohol, propylene glycol, ammonium hydroxide, FD C Blue 2 aluminum lake INTRON A 7.5 mg/mL sodium chloride 1.8 mg/mL sodium phosphate dibasic 1.3 mg/mL sodium phosphate monobasic 0.1 mg/ mL edetate disodium, 0.1 mg/ mL polysorbate 80 1.5 mg/mL m-cresol as a preservative... [Pg.327]

Several strategies to treat alcoholic liver disease have been evaluated. Prednisolone may improve survival in patients with severe alcoholic hepatitis and hepatic encephalopathy. Nutrients such as S-adenosylmethionine and polyunsaturated lecithin have been found to have beneficial effects in nonhuman primates and are undergoing clinical trials. Other medications that have been tested include oxandrolone, propylthiouracil, and colchicine. At present, none of these drugs is approved for use in the U.S. for the treatment of alcoholic liver disease. The current primary treatment for liver failure is transplantation in conjunction with abstinence from ethanol. Long-term outcome studies suggest that patients who are alcohol-dependent have survival rates similar to those of patients with other types of liver disease. Alcoholics with hepatitis C may respond to interferon-2a (see Chapter 52). [Pg.378]

A study found a reduced response to interferon in patients who drank alcohol... [Pg.67]


See other pages where Interferons Alcohol is mentioned: [Pg.341]    [Pg.376]    [Pg.38]    [Pg.6]    [Pg.1145]    [Pg.410]    [Pg.438]    [Pg.674]    [Pg.5132]    [Pg.344]    [Pg.263]    [Pg.384]    [Pg.741]    [Pg.54]    [Pg.300]    [Pg.308]    [Pg.1808]    [Pg.1812]    [Pg.316]    [Pg.17]    [Pg.755]    [Pg.11]    [Pg.3]    [Pg.313]    [Pg.318]    [Pg.530]    [Pg.241]    [Pg.5131]    [Pg.353]    [Pg.178]    [Pg.238]    [Pg.67]    [Pg.67]   
See also in sourсe #XX -- [ Pg.67 ]




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Interferon alfa Alcohol

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