Interferon antibodies

Figlin RA, Itri LM Anti-Interferon antibodies a perspective. Semin. Hematol. (1988) 25(3 Suppl 3) 9-15. 

Development of anti-interferon antibodies and breakthrough hepatitis during treatment for HCV infection in haemophiliacs. Br J Haematol 1996 94(3) 551-6. 

Rajan GP, Seifert B, Prummer O, Joller-Jemelka HI, Burg G, Dummer R. Incidence and in-vivo relevance of anti-interferon antibodies during treatment of low-grade cutaneous T-cell lymphomas with interferon alpha-2a combined with acitretin or PUVA. Arch Dermatol Res 1996 288(9) 543-8. 

Steis RG, Smith JW 2nd, Urba WJ, Clark JW, Itri LM, Evans LM, Schoenberger C, Longo DL. Resistance to recombinant interferon alfa-2a in hairy-cell leukemia associated with neutralizing anti-interferon antibodies. N Engl J Med 1988 318(22) 1409-13. 

Matsuo E, Yamazaki S. Freeze-dried composition containing enzyme-labeled antihuman P-interferon antibody. International Patent 0940205 1989. 

Anti-(infectious bovine rhino-tracheitis antigen) antibody Anti-interferon antibody... 

Ah = Antibody IL = interleukin TNF =tumornecrosis factor INF = interferon LAK =lymphocyte-activated killer CSF =colony stimulating factors and FGF = fibroblast growth factor. 

For the pathogenesis of multiple sklerosis, autoimmune T-lymphocy tes play a predominant role, which are directed against components of the neural myelin sheath. T-lymphocy tes by secreting cytokines such as interferon y maintain the chronic inflammation which destructs the myelin sheath. Also cytotoxic T-lymphocytes may participate directly. The cause of multiple sklerosis is unknown. Significantly increased antibody titers against several vitusses, mostly the measles virus, point to a (latent) virus infection initiating the disease. 

Interferons (EFNs) are a family of multifunctional secreted proteins in vertebrates. Their most prominent functions are their antiviral properties on homologous cells against a wide range of viruses. It is important to note that prior exposure to EFN is required to render cells resistant to viral infection and replication. In contrast to antibodies, EFNs have no direct neutralizing effect on viruses. 

Neutralizing Antibodies Antibodies to beta interferons can form over time and reduce the clinical effect of beta interferons.40 The clinical effect of neutralizing antibodies is seen 18 to... 

Many issues surrounding neutralizing antibodies remain such as standardization of the neutralizing antibody assay, testing recommendations, and treatment recommendations for positive tests 41 Neutralizing antibodies may disappear even with continued treatment. Neutralizing antibodies exhibit cross-reactivity with the other beta interferons.41... 

Choosing Therapy There is no consensus on the best medication for initial therapy. Comparative beta interferon trials indicate better efficacy with more frequent and/or higher dosing.37 This consideration must be balanced with neutralizing antibody development and patient acceptance and tolerance. 

Hartung HP, Munschauer F, Schellekens H. Significance of neutralizing antibodies to interferon beta during treatment of multiple sclerosis expert opinions based on the Proceedings of an International Consensus Conference. Eur J Neurol 2005 12 588-601. 

Biotechnology era beginning First recombinant DNA products Human insulin Human growth hormone Interferons, etc. Monoclonal antibodies Nucleotide blockage Growth in use of natural products and neutraceuticals... 

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