Integrins collagen

Transferrin-R Insulin-R LDL-R matrix compounds (fi-bronectin) Complement-R (C3b and Clq) LPS-R a2-macroglobulin-R RBP-R matrix compounds (integrins, collagen type VI, fibronectin, CD44)... 

De Luca, M., Ward, C.M., Ohmori, K, Andrews, R.K., and Bemdt, M.C. (1995). Jararhagin and jaracetin Novel snake venom inhibitors of the integrin collagen receptor, a p,. Biochem Biophys Res Commun. 206 570-576. 

Collagen is a major component of connective tissue that becomes exposed at the subendothelium of injured blood vessels. It contributes to platelet adhesion and also plays a role in platelet activation by binding to several receptors on platelets such as integrin a 2(3 1 or glycoprotein VI (GP VI). 

Figure 48-4. Schematic representation of a cell interacting through various integrin receptors with collagen, fibronectin, and laminin present in the ECM. (Specific subunits are not indicated.) (Redrawn after Yamada KM Adhesive recognition sequences. J Biol Chem 1991 266 12809.)...

Integrins themselves are found on nearly all cells and mediate several physiological responses, such as cell-cell and cell-matrix interactions. Three families of integrins, each family with a common beta subunit in combination with distinct alpha subunits, have been recognized. The beta 1 family, also called very late lymphocyte-activation antigen or VLA, has receptors mediating extracellular matrix interactions with molecules such as collagen, laminin, and fibronectin. Naturally, platelets contain many of the receptors of the beta 1 family. 

Thus, while glycoprotein Ia/IIa (a2Pj) binds to collagen, glycoprotein Ic/IIa (a ) binds to fibronectin (5). The other integrin belonging to the beta 1 family that is involved in platelet adhesion is ct6P, which binds laminin. 

In the intact blood vessel, ligands involved in adhesion to platelets, such as collagen, fibronectin, and von Willebrand factor, are sequestered in the subendothelium, thus preventing access to platelet adhesive receptors. Table 1 summarizes the functions of platelet membrane integrin receptors. 

D. W., Farndale, R. W., Enzymatically catalyzed disulfide exchange is required for platelet adhesion to collagen via integrin alpha 2 beta l, Blood 102 (2003), p. 2085-2092... 

VWA Integrin /3-subunits Chick collagen ai(VI) VWA (822-999) PSI-BLAST (2) 8 X 10 Drosophila integrin /3 subunit... 

Another 3-D cornea model, comprising rabbit primary cultures of epithelial and stromal cells as well as mouse immortalized endothelial cells, was described in 1994 by Zieske and coworkers [70], They showed the influence of endothelial cells on the formation of a tightly packed, multilayered epithelium as well as the expression of laminin, type VII collagen, a6 integrin, keratin K3, and a-enolase. Furthermore, their findings suggested that the formation of an in vivo-like epithelium requires the cultivation of the 3-D corneal construct under AIC conditions. By contrast, LCC methods of cultivating corneal equivalents in the absence of endothelial cells failed to promote the expression of differentiation markers and basement membrane components. 

Type I collagen can interact with various other molecules in the extracellular matrix and on the cell surface. Cell receptors of type I collagen have been identified and include the heterodimeric integrin family receptors, ctl, 0 2, olO, and ol 1, especially o2/3l, the receptor tyrosine kinase discoidin domain receptor (DDR), and the heparan sulfate membrane proteoglycan syndecan family... 

COLl domain of type XXIII collagen contains multiple copies of a conserved KGD motif used for integrin-mediated cell adhesion by collagen type XVII. ... 

DGEA Collagen Integrin o2pi Without significant preference... 

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