Integrin-mediated cell adhesion

COLl domain of type XXIII collagen contains multiple copies of a conserved KGD motif used for integrin-mediated cell adhesion by collagen type XVII. ... 

Dutta AS, Gormley JJ, Coath M, et al. Potent cyclic peptide inhibitors of VLA-4 (a4 pi Integrin)-mediated cell adhesion. Discovery of compounds like cyclo(MePhe-Leu-Asp-Val-D-Arg-D-Arg) (ZD7349) compatible with depot formulation. 7 Pept Sci 2000 6 398-412. 

Collaborative signaling integrin-mediated cell adhesion modulates signal transduction by other receptors (e.g., receptor tyrosine kinases). 

Chen Q, Kinch MS, Lin TH et al. Integrin-mediated cell adhesion activates mitogen-activated protein kinases. J of Biol Chem 1994 269 26602. 

Giblin, P. A., and Kelly, T. A. (2001). Antagonists of /32 integrin-mediated cell adhesion. 

Early studies on integrin-mediated cell adhesion and signaling demonstrated that cell adhesion to the ECM was accompanied... 

Dutta AS, Crowther M, Gormley JJ, et al. Potent cyclic monomeric and dimeric peptide inhibitors of VLA-4 (a.,Pj integrin)-mediated cell adhesion based on the Ile-Leu-Asp-Val tetrapeptide. J Pep Sci 2000 6 321-41. 

Several of the compounds cited above, e.g. cucurbitacins B, D, and E, together with cucurbitacin I, Fig. (6), were isolated from the fruits of Cucurbita andreana and their activity against COX-1 and COX-2 enzymes was studied. All of the compounds studied exerted a moderate, but significant inhibition of the induced form COX-2, but none of them inhibited the constitutive form COX-1. The range of activity at 100 pg/ml was 32% (cucurbitacin B), 29% (cucurbitacin D), 35% (cucurbitacin E), and 27% (cucurbitacin I), all of which are clearly inferior to the values obtained with specific inhibitors of COX, such as ibuprofen, naproxen, or rofecoxib. Whereas cucurbitacin B was found to inhibit lipid peroxidation by 59% at 100 pg/ml, cucurbitacin I did so only by 23% at the same concentration while the other two compounds were inactive [12]. This mechanism may well be a complementary pathway of action of cucurbitacins in inflammation however, other mechanisms such as the inhibition of integrin-mediated cell adhesion [51] should also be given further consideration. 

But not only integrin-mediated cell adhesion modulates cellular radio- or chemosensitivity. Integrin downstream molecules such as ILK and EAK or integrin-as-... 

Kirchhofer, D., Grzesiak, J., and Pierschbacher, M.D., Calcium as a potential physiological regulator of integrin-mediated cell adhesion, J. Biol. Chem. 266,4471-7,1991. 

Rozzo C, Chiesa V, Caridi G, Pagnan G, Ponzoni M (1997) Induction of apoptosis in human neuroblastoma cells by abrogation of integrin-mediated cell adhesion. Int J Cancer 70 688-698... 

---