Integrins collagen binding

Knight, C. G., Morton, L. F., Peachey, A. R., Tuckwell, D. S., Farndale, R. W., and Barnes, M. J. (2000). The collagen-binding A-domains of integrins 01/51 and < 2/51 recognize the same specific amino acid sequence, GFOGER, in native (triple-helical) collagens./. Biol. Chem. 275, 35-40. 

Knight CG, Morton LF, Peachey AR, Tuckwell DS, Farndale RW, Barnes MJ. The collagen-binding A domains of integrins al 31 and oc2 31 recognize the same... 

Fig. 4.4 Integrins are transmembrane receptors. They are activated by components of the extracellular matnx, such as fibronectin and collagen. These interactions lead to clustering of integrin receptors and the formation of focal adhesions, intracellular cytoskeletal complexes, and formation of actin bundles.30 Activation of integrins is part of the celi-ceil adhesion process, integrins also bind to adhesion moiecules on adjacent celis.

Takada Y, Hemler ME The primary structure of the VLA-2 collagen receptor o2 subunit (platelet OPIa) homology to other integrins and the presence of a possible collagen-binding domain. J Cell Biol 109 397-407,1989... 

Ogle, R.C., Potts, A.J., Yacoe, M. and Little, D.D. (1989) Embryonic chicken fibroblast collagen binding proteins distribution, role in substratum adhesion and relationship to integrins. J. Cell Sci. 94 361-369. 

Collagen is a major component of connective tissue that becomes exposed at the subendothelium of injured blood vessels. It contributes to platelet adhesion and also plays a role in platelet activation by binding to several receptors on platelets such as integrin a 2(3 1 or glycoprotein VI (GP VI). 

Thus, while glycoprotein Ia/IIa (a2Pj) binds to collagen, glycoprotein Ic/IIa (a ) binds to fibronectin (5). The other integrin belonging to the beta 1 family that is involved in platelet adhesion is ct6P, which binds laminin. 

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