Integrin binding protein

CIBl = Calcium- and integrin-binding protein DGBP = D-Galactose binding protein Pmrl = plasma membrane ATP-ase related protein. 

More recently, phages that display known integrin-binding proteins have been shown not only to bind to mammalian cells but also to mediate cellular internalization through a mechanism of receptor-mediated endocytosis [87],... 

The most unusual property of OPN is imparted by the presence of the RGD sequence, which explains the affinity of OPN for integrin and the fact that, hke other integrin-binding proteins (e.g. fibronectin and vitronectin), OPN is often found in association with the extracellular matrix. Consequently, the best-documented biological activities of OPN are its ability to promote adhesion and migration in many types of cells, which appears to depend on the presence of the integrin-binding RGD sequence. 

Yamniuk etal. report the use of CD spectroscopy to measure the structural changes in calcium- and integrin-binding protein upon addition of the divalent metal ions Ca + and Mg + to the metal-lfee apoprotein. They found increases in the a-helical content of the protein of over 30% when either of the metal ions was added to the protein. Futaki et al. showed that the a-hehcal character of a model peptide could be destabihzedby the addition of ferric ion. This destabihzation of the secondary structure was indicated by suppression of the 222 inn signal upon addition of Fe +. The authors concluded a possible ferric/ferrous redox control of the hehcal stmcture of the peptide. 

Hamburger, Z. A. et al. (1999). Crystal structure of invasin a bacterial integrin-binding protein. Science, 286, 291-5. 

Mi LX, Fischer S, Chung B et al (2006) Self-assembling protein hydrogels with modular integrin binding domains. Biomacromolecules 7 38 7... 

Leong, J. M., Fournier, R. S., and Isberg, R. R. (1990). Identification of the integrin binding domain of the Yersinia pseudotuberculosis invasin protein. EMBO J. 9,1979-1989. 

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