Osteoblasts integrin expression

Sinha, R. K., and Tuan, R. S., Regulation of human osteoblast integrin expression by orthopaedic implant metals. Bone 18, 451-457 (1996). 

In addition to mediating cell adhesion, it has been demonstrated that integrin expression by osteoblasts determines their phenotypic expression (see the section Osteoblasts The Bone-Forming Cells ). For example, addition of either soluble concentrations of RGD (Moursi et al, 1996) or antibodies of the integrin pair avp() (Moursi et al., 1997) to confluent osteoblast cultures, blocked initiation and formation of mineral nodules these results provided evidence that integrin-fibronectin interactions leading to extracellular matrix development play a crucial role in osteoblast function (Moursi etal., 1996,1997). 

Orthopedic and dental implant materials bioceramics, 145-146 chemical modifications, 147-148 comparing mechanical properties of, and bone, 146 conventional, 127 costs, 126-127 current materials, 145-148 fate of implanted device, 140-141 integration into surrounding tissue, 127 integrin expression on osteoblasts, 144 integrins, 143-144 metals, ceramics, and polymers, 145 next generation, 127,148-159... 

Wozniak M, Fausto A, Carron CP, Meyer DM, Hruska KA. Mechanically strained cells of the osteoblast hneage organize their extracellular matrix through unique sites of alpha V beta 3-integrin expression. J Bone Miner Res. 2000 15 1731-1745. 

Carvalho, R.S., Schaffer, J.L. and Gerstenfeld, L.C. (1998) Osteoblasts induce osteo-pontin expression in response to attachment on fibronectin demonstration of a common role for integrin receptors in the signal transduction processes of cell attachment and mechanical stimulation. Journal of Cellular Biochemistry 70 376-390... 

Stephansson, S.N., Byers, B.A., and Garda A. J., Enhanced expression of the osteoblastic phenotype on substrates that modulate fibronectin conformation and integrin receptor binding. Biomaterials 23, 2527, 2002. 

Fig. 3 Biomaterial surface chemistry modulates cellular responses. A SAMs presenting different chemistries differentially modulate integrin receptor binding in osteoblasts. B Substrate-dependent differences in osteoblast-specific gene expression correlate with integrin binding specificity. C Matrix mineralization is dependent on integrin binding specificity. Surfaces that support specific binding of asfii integrin exhibit high levels of mineralization. Adapted from [46,48]...

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