Receptor inositol trisphosphate

Bosanac I et al (2002) Structure of the inositol 1,4,5-trisphosphate receptor binding core in complex with its ligand. Nature 420 696-701... 

Bosanac I et al (2005) Crystal structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor. Mol Cell 17 193-203... 

Sarcoplasmic reticulum (SR) is a form of the smoothfaced endoplasmic reticulum (ER) in muscles. It functions as an intracellular Ca2+ store for muscle contraction. Ca2+ is energetically sequestered into the SR by Ca2+-pump/sarcoplasmic endoplasmic reticulum Ca2+-ATPase (SERCA) and released via Ca2+ release channels on stimuli (ryanodine receptor in striated muscles and inositol 1,4,5-trisphosphate receptor in most smooth muscles). Endoplasmic reticulum in non-muscle tissues also functions as an intracellular Ca2+ store. 

Mikoshiba, K. Inositol 1,4,5-trisphosphate receptors. Trends Pharmacol. Sci. 14 86-89,1993. 

Release of intracellular Ca2+ is mediated primarily via inositol 1,4,5-trisphosphate receptors and ryanodine receptors 382... 

Boehning, D., Patterson, R. L., Sedaghat, L. et al. Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosis. Nat. Cell Biol. 5 1051-1061, 2003. 

Nixon GF, Mignery GA, Somlyo AV 1994 Immunogold localization of inositol 1,4,5-trisphosphate receptors and characterization of ultrastructural features of the sarcoplasmic reticulum in phasic and tonic smooth muscle. J Muscle Res Cell Motil 15 682-700 Peng H, Matchkov V, Ivarsen A, Aalkjaer C, Nilsson H 2001 Hypothesis for the initiation of vasomotion. CircRes 88 810-815... 

Adkins CE, Taylor CW 1999 Lateral inhibition of inositol 1,4,5-trisphosphate receptors by cytosolic Ca2+. Curr Biol 9 1115-1118... 

Putney JW Jr 1997 Capacitative calcium entry. Springer-Verlag, Heidelberg Putney JW Jr 1999 TRP, inositol 1,4,5-trisphosphate receptors, and capacitative calcium entry. Proc Natl Acad Sci USA 96 14669-14671... 

Sugawara H, Kurosaki M, Takata M, Kurosaki T 1997 Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor. EMBO J 16 3078-3088... 

Tasker PN, Michelangeli F, Nixon GF 1999 Expression and distribution of the type 1 and type 3 inositol 1,4, 5-trisphosphate receptor in developing vascular smooth muscle. Circ Res 84 536-... 

Kaplin Al, Snyder SH, Linden DJ. 1996. Reduced nicotinamide adenine dinucleotide-selective stimulation of inositol 1,4,5-trisphosphate receptors mediates hypoxic mobilization of calcium. The Journal of Neuroscience 16(6) 2002-2011. 

Weissman, A. M., and Wojcikiewicz, R. j. H. Inositol 1,4,5-trisphosphate receptor ubiquitmation is mediated by mammalian Ubc7, a component of the endoplasmic reticulum-assodated degradation pathway, and is inhibited by chelation of intracellular Zn +. ]. Biol. Chem. 2003, 278, 38238-46. 

G. W. De Young and J. Keizer, A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca " concentration. Proc. Natl. Acad. Sci. USA 89,9895-9899 (1992). 

G. Dupont and L. Combettes, Modelling the effect of specific inositol 1,4,5-trisphosphate receptor isoforms on cellular Ca " signals. Biol. Cell 98, 171-182 (2006). 

Srivastava, M., Atwater, I., Glasman, M., Leighton, X., Goping, G., Caohuy, H., Miller, G., Pichel, J., Westphal, H., Mears, D. Rojas, E and H.B. Pollard, 1999, Defects in inositol 1,4,5-trisphosphate receptor expression, Ca(2+) signaling, and insulin secretion in the anx7(+/-) knockout mouse. Proc. Natl. Acad. Sci. USA 96, 13783-13788. 

Channel activity was increased by elevating the free Ca2+ concentrations on the cytoplasmic side, but increases in the Ca2+ concentration above 1 pM decreased the open probability of PC2 channels. This bell-shaped dependence is similar to that found for the inositol 1,4,5 trisphosphate receptor (InsP3R) and the ryanodine receptor (RyR), but PC2 is more sensitive to Ca2+-dependent inhibition than the RyR, another intracellular channels (Figure 3). 

Matsumoto M, Nakagawa T, Inoue T, NagataE, Tanaka K, Takano H, Minowa O, Kuno J, Sakakibara S, Yamada M, Yoneshima H, Miyawaki A, Fukuuchi Y, Furuichi T, Okano H, Mikoshiba K, Noda T (1996) Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. Nature 379 168-171. 

Street VA, Bosma MM, Demas VP, Regan MR, Lin DD, Robinson LC, Agnew WS, Tempel BL (1997) The type 1 inositol 1,4,5-trisphosphate receptor gene is altered in the opisthotonos mouse. J Neurosci 17 635-645. 

Liberona, J.L., Powell, J.A., Shenoi, S., Petherbridge, L., Caviedes, R., and Jaimovich, E., 1998, Differences in both inositol 1,4,5-trisphosphate mass and inositol 1,4,5-trisphosphate receptors between normal and dystrophic skeletal muscle cell lines, Muscle Nerve, 21, pp 902-909. 

Bezprozvanny I. 2005 The inositol 1,4,5-trisphosphate receptors. Cell Calcium 38, 261-272. 

Jayaraman T., and Marks A.R. 1997 T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis. Mol Cell Biol 17, 3005—3012. 

Nakayama T., Hattori M., Uchida K., Nakamura T., Tateishi Y., Bannai H., Iwai M., Michikawa T., Inoue T., and Mikoshiba K. 2004 The regulatory domain of the inositol 1,4,5-trisphosphate receptor is necessary to keep the channel domain closed possible physiological significance of specific cleavage by caspase 3. Biochem J 377, 299-307. 

Solovyova N., and Verkhratsky A. 2003 Neuronal endoplasmic reticulum acts as a single functional Ca2+ store shared by ryanodine and inositol-1,4,5-trisphosphate receptors as revealed by intra-ER [Ca2+] recordings in single rat sensory neurones. Pflugers Arch 446, 447—454. 

Hirota J, Baba M, Matsumoto M, Furuichi T, Takatsu K, Mikoshiba K. 1998. T-cell-receptor signalling in inositol 1,4,5-trisphosphate receptor (IP3R) type-1-deficient mice is IP3R type 1 essential for T-cell-receptor signalling Biochem J 333 615-9. 

Kirkwood KL, Homick K, Dragon MB, Bradford PG. 1997. Cloning and characterization of the type I inositol 1,4,5-trisphosphate receptor gene promoter. Regulation by 171i estradiol in osteoblasts. J Biol Chem 272 22425-31. 

Hanbauer I, Wink D, Osawa Y, Edelman GM, Gaily JA (1992) Role of nitric oxide in NMDA-evoked release of [3H]-dopamine from striatal slices. Neuroreport 3 409-12 Hartell NA (1994) cGMP acts within cerebellar Purkinje cells to produce long term depression via mechanisms involving PKC and PKG. Neuroreport 5 833-6 Haug LS, Jensen V, Hvalby O, Walaas SI, Ostvold AC (1999) Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic nucleotide-dependent kinases in vitro and in rat cerebellar slices in situ. J Biol Chem 274 7467-73... 

Wagner LE, 2nd, Li WH, Yule DI (2003) Phosphorylation of type-1 inositol 1,4,5-trisphosphate receptors by cyclic nucleotide-dependent protein kinases a mutational analysis of the functionally important sites in the S2+ and S2- splice variants. J Biol Chem 278 45811-7 Wall ME, Francis SH, Corbin JD, Grimes K, Richie-Jannetta R, Kotera J, Macdonald BA, et al. (2003) Mechanisms associated with cGMP binding and activation of cGMP-dependent protein kinase. Proc Natl Acad Sd USA 100 2380-5... 

Deshpande M., Venkatesh K., Rodrigues V. and Hasan G. (2000) The inositol 1,4,5-trisphosphate receptor is required for maintenance of olfactory adaptation in Drosophila antennae. J. Neurobiol. 43, 282-288. 

Cameron, A. M., Nucifora, F. C., Jr., Fung, E. T., Livingston, D. J., Aldape, R. A. el al. (1997). FKBP12 binds the inositol 1,4,5-trisphosphate receptor at leucine-proline (1400-1401) and anchors calcineurin to this FK506-like domain. / Biol. Chem. 272, 27582-27588. 

Cameron, A. M., Steiner, J. P., Roskams, A. J., Ali, S. M., Ronnett, G. V., and Snyder, S. H. (1995b). Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux. Cell83, 463-472. 

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