Lateral inhibition

Notch receptors are especially important during developmental stages by mediating lateral inhibition,... 

Verapamil Direct AV nodal inhibition 1. 5-10 mg IV over 2-3 minutes 2. If necessary, an additional dose of 5-10 mg may be administered 30 minutes later Inhibits digoxin elimination... 

Edgar What about lateral inhibition in neuroblast determination This generates asymmetry that is presumably not dependent on any cell division. This is not intrinsic it relies on cell communication. There must be countless examples of this kind of asymmetry being set up. 

Nasmyth There are many examples where this is a stochastic event. Stochastic can refer to genes flicking on and off, or it can be choosing a position on the cell and marking that point — budding in yeast is a good example of this. Also, in the lateral inhibition, it is which one of the neuroblasts will win out. Once you have established this, you have created a focus for generating asymmetry. 

Nurse Then lateral inhibition is required to reinforce that. 

Sternberg PW 1988 Lateral inhibition during vulval induction in Caenorhabditis elegans. Nature 335 551-554... 

Adkins CE, Taylor CW 1999 Lateral inhibition of inositol 1,4,5-trisphosphate receptors by cytosolic Ca2+. Curr Biol 9 1115-1118... 

As in B. germanica, newly molted males and nymphs elicit wing-raising courtship responses from sexually mature N. cinerea males (Fukui and Takahashi, 1983, 1999 Schal and Bell, 1983). It seems that all individuals, when newly molted, can stimulate male courtship, and that males and nymphs, but not females, produce secondary compounds as they age that reduce this effect. A compound that inhibits male courtship was identified from older nymphs as cis-25,26-epoxyhenpentacontadiene (Fukui and Takahashi, 1999). Whether there is an adaptive advantage for nymphs to stimulate courtship soon after the molt and later inhibit this behavior in mature males is not clear. It is possible that by mimicking females teneral cockroaches are better protected from aggressive males, but this has not been demonstrated. 

However, because of lateral inhibition, you will recover the sensation of being stimulated by a sharp point. The various levels in Figure 7-6 show lateral connections between the neurons from the touch receptors. These connections have the prop erty of inhibiting one another s activities. The firing of the... 

Lateral inhibition, then, is a sharpening, or contrast-enhancement process that makes the relevant stimulus much sharper by suppressing activity in adjacent neurons. This kind of lateral inhibition is an example of a universally useful information-processing mechanism. Under another name, edge detection, it is used in computer processing of pictures such as... 

D. Pan and G. M. Rubin. Kuzhanian controls proteolytic processing of Notch and mediates lateral inhibition during DrosophUa and vertebrate neurogenesis. Cell, 90 (2), 271—280, 1997. 

The presence of chyme in the duodenum stimulates neuronal and endocrine responses that stimulate and later inhibit secretion of acid into the stomach. The stimulatory influences dominate when the pH of gastric chyme is above 3. However, when the buffer capacity is exhausted and the pH falls below 2, inhibitory influences dominate. 

In the croton oil topical inflammation test in mice, 20 pi of a 3% solution of croton oil is applied topically to the anterior and posterior surfaces of one ear and 20 pi of the test drug is applied to the same ear 30 min later. Inhibition of ear swelling by more than 50% relative to vehicle-treated controls measured 2h after croton oil application indicates acute topical anti-inflammatory activity. 

Honda H, Tanemura M, Yoshida A. 1990. Estimation of neuroblast numbers in insect neurogenesis using the lateral inhibition hypothesis of cell differentiation. Development 110 1349-1352. 

Heinbockel T, Ennis M. 2003. Granule cell-mediated lateral inhibition can be driven by metabotropic glutamate receptors. AchemS Abstr XXV 201. 

Pan, D. and Rubin, J. (1997). KUZBANIAN controls proteolytic processing of NOTCH and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell 90 271-280. 

Simpson, P. (1990). Lateral inhibition and the development of the sensory bristles of the adult peripheral nervous system of Drosophila. Development. 709 509-519. 

In the rat, the most often studied animal species, whose tryptophan metabolism resembles closely that of humans, acute ethanol administration, as described earlier, induces a biphasic effect on serum tryptophan levels, an initial increase followed by a later inhibition. Similarly, acute ethanol administration exerts a biphasic effect on brain serotonin synthesis and turnover, an initial enhancement followed by a later inhibition.111 The initial enhancement is caused by an increase in circulating free tryptophan availability to brain, probably secondary to a catecholamine-dependent lipolysis and a nonesteri-fied fatty acid-mediated displacement of the albumin-bound amino acid, whereas the later inhibition of serotonin synthesis and turnover is the result of a decrease in circulating free and albumin-bound tryptophan availability to the brain secondary to activation of hepatic tryptophan 2,3-dioxygenase (TP) by the earlier increase in free tryptophan to the liver. The activation of hepatic TP by acute ethanol administration, which is substrate (tryptophan) mediated, has been described in rats by Badawy and Evans.111127128... 

Meinhardt, H., and A. Gierer. 2000. Pattern formation by local self-activation and lateral inhibition. BioEssays 22 753-60. 

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