Innate immune cells

Locksley RM Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature 2007 447 92-96. 

Do Tregs regulate immune pathology by directly suppressing cells, B cells, plasma cells (reduced IgE is seen in allergic models), or innate immune cells ... 

Liszewski MK, Yokoyama WM, Atkinson JP. 2000. Innate immunity Innate immune cells. Immunology/Allergy, II Innate immunity, ACP Medicine, New York. 

Blach-Olszewska Z. Innate immunity cells, receptors, and signaling pathways. Arch Immunol Ther Exp (Wdrsz). 2005 53 245-253. 

Pathogen Internalization by Innate Immune Cells Phagocytosis and Endocytosis by Siglecs... 

Akira, S., Uematsu, S., Takeuchi, O. Pathogen recognition and innate immunity. Cell 124 (2006) 783-801. 

Anderson, K.V., Bokla, L., Nusslein-Volhard, C. Establishment of dorsal-ventral polarity in the Drosophila embryo-, the induction of polarity by the Toll gene product. Cell 42 (1985) 791-798. Baetz, A., Frey, M., Heeg, K., Dalpke, A.H. Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells. J Biol Chem 279 (2004) 54708-54715. 

In order to induce immune deviadon only two cells need to interact the tolerogenic APC and theT cell. These two cells interact under the influence of innate immune cells within the lymphoid organs. It has been found that ACAID does not occur in the absence of gamma/delta T cells, (Skelsey et al., 2001 Xu and Kapp, 2001), natural killer T (NKT) cells (Sonoda et al., 1999), or B cells (D Orazio et al., 1998a). The innate cells that have been most exclusively studied are the APC and NKT cells. The NKT cell is important in peripheral tolerance induedon in associadon with the AC (Sonoda et al., 1999). 

Taken together, the results summarized above as w ell as additional studies, it is suggestive that timely local innate immune cells with alternative activity, reminiscence of dendritic-like, are required for CNS ability to cope with injurious conditions, and that they are needed at the sub-acute phase follovdng injuries. 

In the previous section we looked at innate immunity. This aspect of the immune system was the poor cousin to acquired immunity for decades, but has recendy graduated to a much higher status because of its relationship to inflammation. Many of the processes involving macrophages and other innate immunity cell types lead to inflammation. Inflammation is known to be the underlying contributor to almost every chronic human disease known, including arthritis, Crohn s disease, diabetes, heart disease, Alzheimer s disease, and stroke. It has recently been shown that inflammation is also linked to cancer. 

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