Injection preservatives

In the empty-cell process, the preservative liquid is forced under pressure into the wood, containing either its normal air content (Lowry process) or an excess of air, by first subjecting the wood to air pressure before applying the preservative under pressure (Rueping process). In the former case, the preservative is put in the cylinder containing the wood at atmospheric pressure, and, in the latter case, under air pressure of 25-100 psi. After the wood has been subjected to the hot preservative (about 190-200°F) underpressure (100-200 psi in the Lowry process and 150-200 psi in the Rueping process) and the pressure has been released, the back pressure of the compressed air in the wood forces out the free liquid from the wood. As much as 20-60 percent of the injected preservative may be recovered, yet good depth of penetration of the preservative is achieved. 

Patients with a reported history of allergic responses to ester and amide anesthetics pose a challenge, especially when regional anesthesia is necessary. Two alternatives may be considered when minor ophthalmic surgical procedures are performed. A 1% solution of diphenhydramine may be prepared by diluting the 5% solution (Benadryl Steri-Vials) with sterile saline. Additionally, injecting preserved sterile saline alone has been shown to be effective for superficial surgical procedures such as papilloma removal and shave biopsies. 

When used systemically, notably in a heparin injection preserved with chlorocresol 0.15%, delayed irritant and hypersensitivity reactions attributed to chlorocresol have been reported. " " See also Section 19. 

For water for injection preserved in containers and sterilized, the JP 2001 provides separate tests for acid or alkali, chloride, ammonium, and residue on evaporation within the monograph. For water for injection prepared by reverse osmosis-ultrafiltration. 

Water for injection Preserve in tightly sealed containers. 

Vinblastine Sulfate, USP. Vinblastine sulfate. Vcihun. vincaleucohlastinc. VLB. NSC-49842, is an antitumor alkaloid isolated from Vim ti rosea L.. the periwinkle plant. It is soluble in water and alcohol. Vials containing 10 mg of vinblastine sulfate as a lyophili/cd plug are supplied. It is reconstituted by the addition of sodium chloride solution for injection preserved with phenol or benzyl alcohol. 

Preservatives. These are included in pharmaceutical preparations to prevent microbial spoilage of the product and to minimize the risk of the consumer acquiring an infection when the preparation is administered. Preservatives must be able to limit proliferation of microorganisms that may be introduced unavoidably into non-sterile products such as oral and topical medications during their manufacture and use. In sterile products such as eye-drops and multi-dose injections preservatives should kill any microbial contaminants introduced inadvertently during use. It is essential that a preservative is not toxic in relation to the intended route of administration of the preserved preparation. 

Hyoscyamine sulfate injection, preserved in single-dose or in multiple-dose containers, preferably of Type I glass (3). 

Vinblastine sulfate is administered by the IV injection of a solution of 1 mg per mL in water for injection or in sodium chloride injection (preserved with phenol or benzyl-alcohol). Usually the ampoule contains 10 mg sterile vinblastine sulfate. 

Framing. The framed bar process is by far the oldest and the most straightforward process utilized in the production of bar soaps. The wet base soap is pumped into a heated, agitated vessel commonly referred to as a cmtcher. The minor ingredients used in soap bars such as fragrance or preservative are added to the wet soap in the cmtcher or injected in-line after reduction of product stream temperature. The hot mixture is then pumped into molds and allowed to cool. 

Chlorbutol (trichlorobutanol trichloro-r-butanol trichlorobutanol). Typical in-use concentration 0.5%. It has been used as a preservative in injections and eyedrops. It is... 

Preservatives may inelude disinfeetant and antiseptic chemicals together with eertain compounds used almost exclusively as preservatives. They are added to mar industrial, including pharmaceutical, products which may, by their nature, support the growth of bacteria and moulds causing spoilage of the product and possibly infection of the user. In the field of pharmaceutical preservation, addition of an inhibitory substance to a multidose injection (Chapter 21) or the prevention of growth in aqueous suspensions ofdmgs intended for oral administration (Chapter 18) are prime examples. 

Preservative availability may be appreciably reduced by interaction with packaging materials. Examples include the permeation of phenolic preservatives into the rubber wads and teats of multi-dose injection or eye-drop containers and by their interaction with flexible nylon tubes for creams. Quaternary ammonium preservative levels in formulations have been significantly reduced by adsorption onto the surfaces of plastic and glass containers. Volatile preservatives such as chloroform are so readily lost by the routine opening and closing of containers that their usefulness is somewhat restricted to preservation of medicines in sealed, impervious containers during storage, with quite short use lives once opened. 

In cases of severe acute asthmatic attacks, bronchodilators and steroids for direct dehveiy to the lungs may be needed in large doses. This is achieved by direct inhalation via a nebulizer device this converts a liquid into a mist or fine spray. The dmg is diluted in small volumes of Water for Injections BP before loading into the reservoir of the machine. This vehicle must be sterile and preservative-fiee and is therefore prepared as a terminally sterilized unit dose in polyethylene nebules. 

The critical feed time t it depends on the location and number of feed pipes, stirrer type, and mixing intensity, and increases with increasing reactor volume. When a constant power-to-volume ratio is preserved, ta-u is proportional to and where D., is the stirrer diameter and Vr the reactor volume (Bourne and Hilber, 1990 Bourne and Thoma, 1991). The productivity of the reactor expressed as the amount of product formed per unit time becomes almost independent of reactor volume. The reason is that the reaction goes to completion in the zone nearby the stirrer tip. The size of this zone increases independently of the tank size it only depends on the velocity of the liquid being injected, the location of the nozzle, and the stirrer geometry and speed of rotation. Accordingly, for rapid reactions, the feed time will also be the reaction time. 

There is no benefit in administering the vaccine after a person has been exposed to the HAV. Two inactivated hepatitis A vaccines, Havrix and VAQTA, are available in the United States and are effective in providing active immunization. The major difference between the two vaccines is that HAVRIX contains 2-phenoxyethanol as a preservative whereas VAQTA is preservative-free.1 Either vaccine is effective in providing active pre-exposure prophylaxis when given in two injections 6 months apart (referred to as months 0 and 6). The two vaccines are considered interchangeable, and doses are dependent on age (Table 21-3). 

Applications On a comparative basis, HTGC is a relatively new tool and extremely valuable for the analyses of extracted polymer additives, as shown by industrial problem solving. For satisfactory analysis of in-polymer additives by HTGC two specific conditions are to be met. The instrument should be equipped with a cool on-column injection port to better preserve some of the additives and/or their by-products that may be thermally labile. The instrument must also have electronic pressure control so that some of the very high-boiling components, such as Irganox 1010, are... 

Substances that have been used as preservatives for disperse systems include chlorocresol, chlorobutanol, benzoates, phenylmercuric nitrate, parabens, and others [76,77]. The use of cationic antimicrobial agents such as quaternary ammonium compounds (e.g., benzalkonium chloride) is contraindicated in many cases because they may be inactivated by other formulation components and/or they may alter the charge of the dispersed phase. Clay suspensions and gels should be adequately preserved with nonionic antimicrobial preservatives. The use of preservatives is generally limited to products that are not intended for parenteral use. Intravenous injectable... 

In contrast, parenteral suspensions have relatively low solids contents, usually between 0.5 and 5%, with the exception of insoluble forms of penicillin in which concentrations of the antibiotic may exceed 30%. These sterile preparations are designed for intramuscular, intradermal, intralesional, intraarticular, or subcutaneous injection. Syringeability is an important factor to be taken into consideration with injectable dosage forms. The viscosity of a parenteral suspension should be sufficiently low to facilitate injection. Common suspending vehicles include preserved isotonic saline solution or a parenterally acceptable vegetable oil. Ophthalmic and optic suspensions that are instilled into the eye/ear must also be prepared in a sterile manner. The vehicles are essentially isotonic and aqueous in composition. The reader should refer to Chapter 12 for further discussion on parenteral products. 

More subtle effects of preservatives on injectable formulations are possible. Formulation of insulin is an illustrative case study. Insulin is usually formulated as a multiple-dose vial, since individual dosage varies among patients. Preservation of zinc insulin with phenol causes physical instability of the suspension, whereas methyl-paraben does not. However, the presence of phenol is required for obtaining protamine insulin crystals [9]. 

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