Hyoscyamine sulfate

Contac 12-hour capsules Phenylpropanolamine hydrochloride, chlorpheniramine maleate, atropine sulfate, scopolamine hydrobromide, hyoscyamine sulfate SmithKline Consumer Products... 

Hydromorphone Hydroxocobalamin Hydroxychloroquine Hydroxyethyl starch Hydroxyprogesterone caproate Hyoscyamine sulfate... 

Natural alkaloids, tertiary amines atropine sulfate hyoscine butylbromide hyoscine hydrobromide hyoscyamine sulfate... 

Antispasmodics dicyclomine hyoscyamine sulfate pinaverium bromide trimebutine... 

LEVSIN elixir contains 0.125 mg hyoscyamine sulfate per 5 mL with 20% alcohol for oral administration. LEVSIN elixir also contains, as inactive ingredients,... 

Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate, and Scopolamine Hydrobromide Elixir... 

Each 5 mL (teaspoonful) of elixir (23% alcohol) contains phenobarbital 16.2 mg, hyoscyamine sulfate 0.1037 mg, atropine sulfate 0.0194 mg, and scopolamine hydrobro-... 

Hyoscyamine Sulphate elixir Hyoscyamine Sulfate injection Hyoscyamine Sulphate oral solution Hyoscyamine Sulphate tablets Glass, 1.8 M X 2mm I.D. 3% liquid G3/S1AB Nitrogen 225 FID Hydrobromide USP (24, pp. 851, 852 and 853)... 

Hyoscyamine is Ihe lero form of Ihe racemie mixture known as atropine. The dextro form does not exist naturally but has been synthesized. Cushny compared the activities of (-)-hyoscyamine. (-) )-hyoseyaminc. and Ihe racemate (atropine) in 1904 and found greater peripheral potency for Ihe (-) isomer and twice Ihe potency of the racemate. All later studies have essentially confirmed that the (-)-) isomer is only weakly active and that Ihe (-) i.somer is. in effect. Ihe active portion of alropinc. Inspection of the relative do.ses of alropinc sulfate and hyo.scyamine sulfate illustrates the differences very nicely. The principal criticism offered against the use of hyoscyamine. sulfate cxclu.sively is that it lends to rdccmizc to atropine sulfate rather easily in solution, so that atropine sulfate llicn becomes the more stable of Ihe two. All of the isomers behave very much the. same in Ihe CNS. 

Hyoscyamine Sulfate. USP. Hyo.scyaminc sulfate (laavsin sulfate) is a white, odorless, crystalline compound of a deliquescent nature that also is affected by light. It is soluble in water 1 0.5) and alcohol (1 5) but almost insoluble in ether. Solutions of hyo.scyamine sulfate are acidic to litmus. 

Cystospaz Levsin (The base) Egacene Egazil Duretter Peptard (Hyoscyamine sulfate dihydrate). 

Hyoscyamine sulfate occurs as needles (from alcohol) (1), or as a white crystalline powder or colorless needles (2). 

One gram of hyoscyamine sulfate dihydrate dissolves in 0.5 ml water in about 5 ml alcohol, very slightly soluble in chloroform and ether (1). 

A commercially available extended-release capsule (Levsinex TimecapsR) contains small beads of hyoscyamine sulfate which are surrounded by a porous membrane that permits fluids to enter and dissolve the drug. The manufacturer states that 0.375 mg of drug is delivered from a capsule at an approximate rate of 0.125 mg/4 hours. In a crossover study comparing extended-release capsules and conventional tablets, bioavailability (as determined by area under the plasma concentrationtime curve) during the first 4 hours after administration of a single 0.375 mg dose as extended-release capsules, was about 43% that of a single 0.125 mg dose as conventional tablets when the data were corrected for difference in dose (51). 

Following parenteral administration of hyoscyamine sulfate, the drug has an onset of action of 2 to 3 minutes peak pharmacologic action occurs within 15 to 30 minutes and persists for up to 4 hours. 

Hyoscyamine sulfate injection, preserved in single-dose or in multiple-dose containers, preferably of Type I glass (3). 

The following identification tests are mentioned in the USP XXI (3) under hyoscyamine sulfate. 

A The infrared absorption spectrum of a potassium bromide dispersion of it, previously dried, exhibits maxima only at the same wavelengths as that of a similar preparation of USP Hyoscyamine Sulfate RS. 

Melting temperature not less than 200. Specific rotation not less than -24, calculated on the dried basis, determined in a solution containing 500 mg of hyoscyamine sulfate in each 10 mL. 

Dissolve about 1 g of hyoscyamine sulfate, accurately weighed, in 50 mL of glacial acetic acid and titrate with 0.1N perchloric acid VS, determining the end-point potentiometrically. Perform a blank determination, and make any necessary correction. 

The BP (2) recommends the following method for the assay of hyoscyamine sulfate ... 

The BP (2) describes the following UV procedure to detect apo-atropine in hyoscyamine sulfate. 

---