Screening initial risk

The documenf notes that carrying out a comprehensive risk assessment is time consuming and expensive. A tiered approach should be taken. On many sites the initial risk screening will be sufficient to characterise the risk. It is, however, essential that a full site investigation and an appropriate level of risk assessment is carried out and that it is demonstrated that any risk management measures that are proposed are sufficient to reduce the risk of harm to the development and its occupants to an acceptable level for as long as the hazard exists. 

The initial, consequence, or risk screening results indicated that the building was designed or sited such that it was not a concern relative to explosion or fire events. As a result, the building was screened out as not needing further consideration. 

The initial, consequence, or risk-screening results did not clearly determine that the building was a major concern, nor could the building be removed from further evaluation on the basis of any of the screens. 

The initial, consequence, or risk-screening results indicated that the building design or siting presented significant concern. 

White JV, Ham RJ, Lipschitz DA, et al. Consensus of the Nutrition Screening Initiative Risk factors and indicators of poor nutritional status in older Americans. Journal of the American Diabetic Association 91 783-787,1991. 

The plant internal PSA can be used to identify critical equipment that could be damaged by fire. This form of screening was employed in the fire-risk portions of ZIP. At each location considered, the loss of all the equipment in the zone is postulated regardless of the size or position of the fire in the zone. If this does not show the occurrence of an initiating event (LOCA or transient) or if the safety functions are not damage to required for safe shutdown, the location is eliminated from consideration. If the location is found to be critical, it is considered furilier lot-detailed fire growth and fire suppression analyses. 

Groundwater vulnerability maps, based on a regional assessment using an index-based system, can be used as a screening tool to rapidly assess the relative scale of impacts arising from pressures. They may be useful for assessing whether ground-water bodies are at risk from pollution sources at initial characterisation. 

Secondary prevention is aimed at preventing malignancy in a population that has already manifested an initial disease process. Secondary prevention includes procedures ranging from colonoscopic removal of precan-cerous polyps detected during screening colonoscopy to total colectomy for high-risk individuals (e.g., familial adenomatous polyposis). 

The Secretary of Homeland Security determines which chemical facilities must meet the security requirements of DHS regulations based on the degree of risk posed by each facility. However, initially, screening of chemical facilities for compliance requirements was done on the basis of potential consequence rather than risk. 

The appropriate level of personal protection necessary to safely perform the site characterization activities will depend on the assessment of site hazards that might pose a risk to the site characterization team. The hazard assessment may be further refined during the approach to the site, based on the results of the field safety screening and initial observations of site conditions. Two general scenarios are considered, one in which there are no obvious signs of immediate hazards, and one in which there are indicators of site hazards. 

Thus, the acetylator status of a patient as determined by the NAT2 genotype appears to be an important determinant of the risk for SSZ toxicity based on the limited data published so far (see Table 14.3). Although more studies and data are clearly needed, this suggests that prospective screening of patients for the NAT2 genotype prior to initiation of SSZ may be a useful tool to prevent SSZ toxicity. 

Albumin (human) Epoetin alfa contains albumin, a derivative of human blood. Based on effective donor screening and product manufacturing processes, it carries an extremely remote risk for transmission of viral diseases. No cases of transmission of viral diseases or Creutzfeldt-Jakob disease have ever been identified for albumin. Anemia Not intended for CRF patients who require correction of severe anemia epoetin alfa may obviate the need for maintenance transfusions but is not a substitute for emergency transfusion. Not indicated for treatment of anemia in HIV-infected patients or cancer patients due to other factors such as iron or folate deficiencies, hemolysis, or Gl bleeding, which should be managed appropriately. Hypertension Up to 80% of patients with CRF have a history of hypertension. Do not treat patients with uncontrolled hypertension monitor blood pressure adequately before initiation of therapy. Hypertensive encephalopathy and seizures have occurred in patients with CRF treated with epoetin. 

Screening patients for bipolar disorder Prior to initiating treatment with an antidepressant, adequately screen patients with depressive symptoms to determine if they are at risk for bipolar disorder. 

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