Inhibition of Monoamine Oxidases

Medvedev AE, Veselovsky AV, Shvedov VI, Tikhonova OV, Moskvitina TA, Fedotova OA, et al. Inhibition of monoamine oxidase by pirlindole analogues 3D-QSAR and CoMFA analysis. / Chem Inf Comput Sci 1998 38 1137-44. Miller JR, Edmondson DE. Structure-activity relationships in the oxidation of para-substituted benzylamine analogues by recombinant human liver monoamine oxidase A. Biochemistry 1999 38 13670-83. 

It is premature to define the exact mechanism by which DA is involved in the response to METH or MDMA. It is known- that these drugs release large quantities of DA and that DA can be readily oxidized to reactive metabolites, which could possibly cause destruction of nerve terminals (Graham 1978 Maker et al. 1986). Moreover, these effects could be enhanced by inhibition of monoamine oxidase, which is known to occur with these drugs (Susuki et al. 1980). The possibility that 6-DOHA is formed and subsequently destroys the nerve terminals, as suggested by Seiden and Vosmer (1984), also requires investigation. 

Inhibition of monoamine oxidase has been proposed as a possible mechanism underlying the hydrogen sulfide-mediated disruption of neurotransmission in brain stem nuclei controlling respiration (Warenycia et al. 1989a). Administration of sodium hydrosulfide, an alkali salt of hydrogen sulfide, has been shown to increase brain catecholamine and serotonin levels in rats. It has also been suggested that persulfide formation resulting from sulfide interaction with tissue cystine and cystinyl peptides may underlie some... 

Inhibition of monoamine oxidase B by allenic amines R. A. Smith, R. L. White,... 

Wolf AP, Warner D, Zezulkova I, Cilento R. (1996a). Inhibition of monoamine oxidase B in the brains of smokers. Nature. 379(6567) 733-6. 

Fernandez de Arriba A, Lizcano JM, Balsa MD, Unzeta M. (1994). Inhibition of monoamine oxidase from bovine retina by beta-carbolines. J Pharm Pharmacol. 46(10) 809-13. 

INHIBITION OF MONOAMINE OXIDASE BY ARALKYL- AND ARYLOXYALKYL-GUANIDINES... 

Pharmacology Selegiline hydrochloride is a levorotatory acetylenic derivative of phenethylamine. Although the mechanism of action is not fully understood, inhibition of monoamine oxidase (MAO) type B activity is of primary importance and selegiline... 

There is good evidence that the facilitation of peripheral sympathetic nervous system transmission prcxluced by the amphetamines also occurs in the CNS.The possibihty that amphetamines act indirectly (i.e., by releasing monoamines) at monoaminergic synapses in the brain and spinal cord seems likely. However, amphetamine has effects beyond displacement of catecholamines these include inhibition of neuronal amine uptake, direct stimulation of dopamine and serotonin receptors, antagonism of catecholamine action at certain subtypes of adrenoceptors, and inhibition of monoamine oxidase. Interestingly, none of these actions explains the therapeutic benefit of the amphetamines in hyperkinetic children. 

M.G. Palfreyman, I.A. McDonald, J.R. Fozard, Y. Mely, A.J. Sleight, M. Zreika, J. Wagner, P. Bey, P.J. Lewis, Inhibition of monoamine oxidase selectively in brain monoamine nerves using the bioprecursor (MDL 72394), a substrate for aromatic L-amino acid decarboxylase, J. Neurochem. 45 (1985) 1850-1860. 

B. Testa, Inhibition of monoamine oxidase-B by 5H-indeno[1,2-c]pyridazines Biological activities, quantitative structure-activity relationships (QSARs) and 3D-QSARs, J. Med. Chem. 38 (1995) 3874-3883. 

R.W. Fuller, M.M. Marsh, J. Mills, Inhibition of monoamine oxidase by A/-(phenox-yethyl)cyclopropylamines. Correlation of inhibition with Hammett constants and partition coefficients, J. Med. Chem. 11 (1968) 397-398. 

S. Ye, S. Yoshida, R. Frohlich, G. Haufe, K.L. Kirk, Fiuorinated phenyicyciopropyiamines. Part 4. Effects of aryl substituents and stereochemistry on the inhibition of monoamine oxidases by 1-aryl-2-fluoro-cyclopropylamines, Bioorg. Med. Chem. 13 (2005) 2489-2499. 

Differentiating between types of aggression can be pertinent to medication trials. Chronic inhibition of monoamine oxidase or serotonin (5-hydroxtryptamine [5-HT]) uptake, with antidepressant treatment, reliably facilitates defensive aggression but not attack behavior in rodents (Miczek et ah, 1994). Thus, at least in animal studies, affective and predatory types of aggression differ in their psychopharmacologic response. 

Johnstone EC. The relationship between acetylator status and inhibition of monoamine oxidase, excretion of free drug and antidepressant response in depressed patients on phenelzine. Psychopharmacoiogia 1976 46 289-294. 

The combination of pethidine with monoamine oxidase inhibitors (MAOIs) can cause serious adverse reaction, which can present in two distinct forms. The excitatory form is characterised by sudden agitation, delirium, headache, hypo- or hypertension, rigidity, hyperpyrexia, convulsions and coma. It is thought to be caused by an increase in cerebral 5-HT concentrations because of inhibition of monoamine oxidase. This is potentiated by pethidine, which blocks neuronal uptake of 5-HT. The depressive form, which is frequently severe and fatal, consists of respiratory and cardiovascular depression and coma. It is the result of the inhibition of hepatic microsomal enzymes by the MAOI, leading to accumulation of pethidine. Phenoperidine should also be avoided in patients taking MAOI drugs but other opioids appear to be safe. 

Reserpine has several putative modes of action including the blocking of NE reuptake, inhibition of monoamine oxidases, and depletion of NE and 5-HT stores. The drug comes pure or as the whole root which is. . pu Ax /)... 

INHIBITION OF MONOAMINE OXIDASE B BY BANISTERINE AND SELEGILINE AND THE INITIAL RATIONALE OF USING THEM IN PARKINSON S DISEASE... 

GINKGO BILOBA EXTRACT AND INHIBITION OF MONOAMINE OXIDASE A AND B IN LIVING HUMAN BRAIN... 

Hypertensive crisis potentiation of central effects of drugs or food components due to inhibition of monoamine oxidase... 

Finberg JPM, Pacak K, Kopin IJ, Goldstein DS (1993) Chronic inhibition of monoamine oxidase type-A increases noradrenaline release in rat frontal cortex. Naunyn-Schmied Arch Pharmacol 347i500-505. 

Carbolines exert a variety of pharmacological effects, including sedation, catalepsy, inhibition of convulsion, hallucination, and inhibition of monoamine oxidases (MAO) and of monoamine uptake (104a,b). Extensively investigated was the inhibition of MAO by /3-carbolines, which is probably responsible for their antidepressant effects in man (5d). p-Caibolines inhibit the oxidative deamination of serotonin at micromolar... 

The first class of antidepressants was developed in the early 1950s with the discovery of an antitubercular drug iproniazid that possesses mood-elevating properties (Nutt, 2002). Iproniazid is a monoamine oxidase inhibitor (MAOl). Monoamine oxidase is the enzyme that breaks down serotonin, dopamine, and norepinephrine. The inhibition of monoamine oxidase increases levels of monoamines in the synapse. 

FIGURE 31.6 PET scans showing dose dependency and time dependency of lazabemide inhibition of monoamine oxidase, type B in human brain. (Reproduced with permission from Fowler JS, Volkow ND, Wang G-J, Dewey SL. J Nucl Med 1999 40 1154-63.)... 

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