Monoamine oxidases inhibition

Hydrazides of isonicotinic acid have been used as antidepressant agents by virtue of their monoamine oxidase-inhibiting activity the pyridine ring has been shown to be replaceable by an... 

Neff, NH and Costa, E (1966) The influence of monoamine oxidase inhibition on catecholamine synthesis. Life Sci. 5 951-959. 

Fuller, R.W. Serotonin oxidation by rat brain monoamine oxidase Inhibition by 4-chloroamphetamine. Life Sci 5 2247-2252, 1966. 

Monoamine oxidase inhibition Serotonin reuptake inhibition Norepinephrine reuptake inhibition Dopamine reuptake inhibition a2-Adrenergic receptor blockade Serotonin-2A receptor blockade Serotonin-2C receptor blockade Serotonin-3 receptor blockade op-Adrenergic receptor blockade Histamine-1 receptor blockade Muscarinic cholinergic receptor blockade... 

Warenycia MW, Smith KA, Blashko CS, et al. 1989c. Monoamine oxidase inhibition as a sequel of hydrogen sulfide intoxication Increases in brain catecholamine and 5-hydroxytryptamine levels. Arch Toxicol 63 131-136. 

Buckholtz, N., Boggan, W. Monoamine oxidase inhibition in brain and liver produced by b-carbohnes structure activity relationships and substrate specihcity. Biochem. Pharmacol. 26 1991, 1977. 

Guillem K, VouiUac C, Azar MR, Parsons LH, Koob GF, Cador M, Stinus L (2005) Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats. J Neu-rosci 25 8593-8600... 

The major routes for the synthesis and metabolism of noradrenaline in adrenergic nerves [375], together with the names of the enzymes concerned, are shown in Figure 3.1. Under normal conditions the rate controlling step in noradrenaline synthesis is the first, and the tissue noradrenaline content can be markedly lowered by inhibition of tyrosine hydroxylase [376]. Tissue noradrenaline levels can also be lowered, but to a lesser extent, by inhibition of dopamine-(3-oxidase [377, 378]. However, the noradrenaline depletion produced by guanethidine is unlikely to result from inhibition of synthesis, since intra-cisternal injection of guanethidine does not prevent the accumulation of noradrenaline which follows brain monoamine oxidase inhibition, even though it does cause depletion of brain noradrenaline [323]. 

There is no correlation between the monoamine oxidase inhibitory activity of guanidine derivatives and their ability to cause adrenergic neurone blockade or depletion of noradrenaline [259]. The contribution made by monoamine oxidase inhibition to the antihypertensive properties of guanidines remains to be... 

The significance of monoamine oxidase inhibition as a contributory factor, to the antihypertensive action of some adrenergic neurone blocking dmgs (see p. 186), has received further support. The tetrahydroisoquinoline derivatives debrisoquine (VII) and guanisoquin (LXVil, R = 7-Br, = H) are... 

There is no place anymore for the amphetamines in our therapeutic armamentarium. The only indications for the other stimulants, modaflnil and methylphenidate, are respectively narcolepsy and the attention deflcit disorders (ADHD) and hyperactivity syndromes in children. Their mechanisms of action include enhanced release of dopamine and norepinephrine, re-uptake inhibition of dopamine and norepinephrine and to some extend monoamine oxidase inhibition. 

L. Maitre, Monoamine oxidase inhibiting properties of SU-11,739 in the rat. Comparison with pargyline, tranylcypromine, and iproniazid, J. Pharmacol. Exp. Ther. 157 (1967) 81-88. 

Blackwell, B. (1963) Hypertensive crisis due to monoamine-oxidase inhibition. Lancet 2 849-851. 

Grahame-Smith DG, Green AR The role of brain 5-hydroxytryptamine in the hyperactivity produced in rats by lithium and monoamine oxidase inhibition. Br J Pharmacol 52 19-26, 1974... 

Kupfer DJ, Bowers MB REM sleep and central monoamine oxidase inhibition. Psychopharmacologia 27 183-190, 1972... 

The ability to monitor the presumed mechanism of action (i.e., monoamine oxidase inhibition) using platelets as a surrogate rather than monitoring the plasma drug level... 

Robinson D, Kurtz W. Monoamine oxidase inhibiting drugs pharmacologic and therapeutic issues. In Meltzer H, ed. Psychopharmacoiogy the third generation of progress. New York Raven Press, 1987. 

Tranylcypromine Adrenergic nerve terminals (monoamine oxidase) Inhibits enzyme increases stored transmitter pool... 

Monoamine oxidase inhibition Monoamine oxidase A, monoamine oxidase B. 

Monoamine oxidase inhibition monoamine oxidase A monoamine oxidase B ... 

NEUROTROPHIC-LIKE ACTION OF SELEGILINE RESCUE OF AXOTOMIZED MOTORNEURONS INDEPENDENT OF MONOAMINE OXIDASE INHIBITION... 

EDS is usually treated using amphetamine-like CNS stimulants or modaflnil, a novel wake-promoting compound unrelated to amphetamines. The most commonly used amphetamine-like compounds aremethamphetamine, D-amphetamine, methylpheni-date, pemoline, and mazindol. The most important pharmacological property of these compounds is to release catecholamines, i.e., dopamine and norepinephrine. Amphetamine-like compounds also share the property of blocking the reuptake and the degradation of these monoamines (monoamine oxidase inhibition at high doses). All these properties presynaptically enhance dopamine transmission, which are likely to contribute to the EEG arousal effects of amphetamines. 

Maynard, L. S. and Schenker, V. J. (1996). Monoamine-oxidase inhibition by ethanol in vitro. Nature 196,575-576. 

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