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Influence of formulation

The results of incorporating pilocarpine (V) (a relatively water-soluble dmg) and fluoro-metholone (a lipophilic dmg) into a water-inoil ointment base can be compared in Fig. 9.36. Pilocarpine is thought to be released only when in contact with aqueous tear fluid, whereas the steroid, being soluble in the base, can diffuse through the base to replenish the surface concentrations and thus produce a sustained effect. [Pg.369]

Hydrophilic polymeric vehicles, such as poly (vinyl alcohol) (PVA) and hydroxypropyl-methylcellulose (HPMC), are used in ophthalmic formulations. PVA increases the effectiveness of the dmg substance. HPMC has likewise been found to reduce the effective dose of neomycin sulfate required to prevent infection of corneas of experimental animals (Table 9.11). [Pg.370]

Eye drops are often formulated to be isotonic with tear fluid but deviations from tonicity do not cause problems, although hypertonicity may cause stinging of the eye and hypotonicity may increase the permeability of the cornea. [Pg.370]

Some ingredients of eye medications may increase the permeability of the cornea. Surface-active agents are knovm to interact with membranes to increase the permeability benzalkonium chloride has surfactant properties and may well have some effect on comeal permeability, although its primary purpose is as a bacteriostat and bactericide. Chlorhexidine acetate and cetrimide, both of which are surface-active, are also used. [Pg.370]

The influence of log P of beta-blockers (Table 9.12) on their permeation coefficients into conjunctiva and cornea is shown in Fig. 9.37. In humans, the conjunctiva has 17 times the surface area of the cornea and therefore it absorbs significant amounts of dmg. Work has centred on increasing corneal permeability or retention of the dmg (or product) in the conjunctiva sac. Appropriate doses of dmg can achieve a degree of comeal or conjunctival selectivity, represented in Fig. 9.37(c) by the ratio (C/y). Increasing lipophilicity increases the C// ratio from 0.1 to approximately 0.5. [Pg.370]


P. Finholt, Influence of formulation on dissolution rate, 32. in Dissolution Technology (L. J. Leeson and J. T. Car-stensen, eds.), Academy of Pharmaceutical Sciences, American Pharmaceutical Association, Washington,... [Pg.125]

Groves, M. (1966). The influence of formulation upon the activity of thermotherapeutic agents. Rep. Progr. Appl. Chem. 12 51-151. [Pg.502]

Scholz M, Lin JE, Lee VE1, Keipert S. Pilocarpine permeability across ocular tissues and cell cultures Influence of formulation parameters. J Ocul Pharmacol Ther 18 455-468 (2002). [Pg.303]

Ng SS, Figg WD, Sparreboom A. Taxane-mediated antiangiogenesis in vitro influence of formulation vehicles and binding proteins. Cancer Res 2004 64 821. [Pg.60]

Capan, Y., Woo, B.H., Gebrekidan, S., Ahmed, S., and Deluca, P.P. (1999). Influence of formulation parameters on the characteristics of poly(D,L-lactide-co-glycolide) microspheres containing poly(L- lysine) complexed plasmid DNA. J. Control. Release, 60, 279-286. [Pg.303]

Taha El, Zaghloul A A, Kassem AA, Khan MA. Salbutamol sulfate suppositories influence of formulation on physical parameters and stability. Pharm Dev Technol 2003 8(1) 21 30. [Pg.213]

Smyth HDC. The influence of formulation variables on the performance of alternative propellant-driven metered dose inhalers. Adv Drug Delivery Rev 2003 55(7) 807-828. [Pg.245]

Poll GP, Grim WM, Bacher FA, Yunker MH. Influence of formulation on aerosol particle size. J Pharma Sci 1969 58 484-486. [Pg.247]

French DL, Edwards DA, Niven RW. The influence of formulation on emission, deaggregation and deposition of dry powder for inhalation. J Aerosol Sci 1996 27(5) 769-783. [Pg.247]

C. Influence of Formulation and Processing Factors on Physical State of the Drug... [Pg.281]

Smyth, H. D., Beck, V. P, Williams, D., and Hickey, A. J. (2004),The influence of formulation and spacer device on the in vitro performance of solution chlorofluorocarbon-free propellant-driven metered dose inhalers, AAPS PharmSciTech, 5, E7. [Pg.720]

Thorgeirsdottir, T. O., Thormar, H., and Kristmundsdottir, T. (2005), The influence of formulation variables on stability and microbicidal activity of monoglyceride monocaprin, /. Drug Deliv. Sci. Tech., 15, 233-236. [Pg.860]

Newton, M., Petersson, J., Podczeck, F., Clarke, A., and Booth, S. (2001), The influence of formulation variables on the properties of pellets containing a self-emulsifying mixture,/. Pharm. Sci., 90, 987-995. [Pg.1125]

Ceballos, A., Cirri, M., Maestrelli, F., Corti, G., and Mura, P. (2005), Influence of formulation and process variables on in vitro release of theophylline from directly-compressed Eudragit matrix tablets, Farmaco, 60, 913-918. [Pg.1216]

Table II. The influence of formulation on the efficacy of hydroprene and methoprene on Blattella germanica nymphs when applied to a latex paint substrate. Table II. The influence of formulation on the efficacy of hydroprene and methoprene on Blattella germanica nymphs when applied to a latex paint substrate.
Aman W, Thoma K. The influence of formulation and manufacturing process on the photostabiUty of tablets. Int J Pharmaceut 2002 243 33 1. [Pg.37]

Fatouros, A. Sjostrom, B. Recombinant factor VIII SQ—The influence of formulation parameters on structure and surface adsorption. Int. J. Pharm. 2000, 194, 69-79. [Pg.300]

Igartua, M. Hernandez, R.M. Esquisabel, A. Gascon, A.R. Calvo, M.B. Pedraz, J.L. Influence of formulation variables on the in-vitro release of albumin from biodegradable microparticulate systems. J. Microencapsul. 1997,14 (3), 349-356. [Pg.2327]

Wang, H.T. Schmitt, E. Flanagan, D.R. Linhardt, R.J. Influence of formulation methods on the in vitro controlled release of protein from poly(ester) microspheres. J. Controlled Release 1991, 17, 23-32. [Pg.2327]

In this chapter, various aspects of drug photoreactivity are presented. Common photochemical reactions by which drugs have been found to decompose are described. The influence of formulation factors, e.g., excipients, on product stability is discussed. Finally, variables that have to be considered in photostability studies are noted. [Pg.2859]

Nastruzzi, C Cortesi, R. Esposito, E. Genovesi, A. Spa-doni. A. Vecchio, C. Menegatti, E. Influence of formulation and process parameters on pellet production by powder layering technique. AAPS Pharm. Sci. Tech. 2000,1 (2), 1-22. [Pg.3294]

Landoni, M.F. Lees, P. Influence of formulation on the pharmacokinetics and bioavailability of racemic ketoprofen in horses. J. Vet. Pharmacol. Ther. 1995c, 18, 446-450. [Pg.3974]

Sanders LM, Burns R, Bitale K, Hoffman P. Clinical performance of nafarelin controlled release injectable influence of formulation parameters on release kinetics and duration of efficacy. Proc Int Symp Control Rel Bioact Mater 1988 15 62-63. [Pg.27]

McCarthy TJ, Myburgh JA, Butler N. Further studies on the influence of formulation on preservative activity. Cosmet Toilet 1977 92(3) 33-36. [Pg.63]

Delporte JP, Jaminet E Influence of formulation of enteric coated tablets on the bioavailability of the drug [in French]. / Pharm Belg 1976 31 263-276. [Pg.357]

Bosquillon C, Lombry C, Preat V, Vanbever R. Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance. J Control Release 2001 70 329-39. [Pg.267]

Santos Veiga F, Pina M. et al. Physical properties of chitosan pellets produced by extnision-spheronization influence of formulation variables. Int J Pharm 2002 246 153-69-... [Pg.361]

Schroder M, Kleinebudde P. Influence of formulation parameters on dissolution of pro-pylphenazone pellets. Eur J Pharm Biopharm 1995 41 382-7. [Pg.362]


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