Influence of product formulation on ablation

Ablation is particularly noticeable during sublimation although losses can be detected during prefreezing if the product is frozen by evapora- 

Ablation can be reduced by including excipients in the formulation which form a cohesive cake structure, although data from this laboratory using Escherichia coli as a trace organism has demonstrated that ablation losses are detectable even from an apparently well formulated product. The results of this study can be summarised as follows  

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