Industrial Bio-Test Laboratories

FMC. 1965. Three-generahon reproduction study in albino rats on thiodan Results through weaning of Fib litters. Conducted for Food Machinery and Chemical Corporation, Niagara Chemical Division. Industrial Bio-Test Laboratories, Inc., Northbrook, IF. 

University of Massachusetts Industrial Bio-Test Laboratories AME Associates AME Associates Continental Can Co. 

IBT. 1972a. Acute dust inhalation toxicity study with biomet (tri-n-butyltin fluoride) in albino rats. Report to M and T Chemicals, Inc., Rahway, NJ, by Industrial Bio-Test Laboratories, Inc.,... 

One of the firms inspected by the FDAwas Industrial Bio-Test Laboratories (IBT). At the time it was one of the largest contract testing facilities in the world. IBT had conducted literally thousands of preclinical safety studies that were submitted to the FDA to establish the safety of drugs awaiting... 

Mild and reversible effects of inhaling ammonia have been documented in several studies of human subjects exposed to ammonia at various concentrations and durations. Those studies are outlined in Table 2—4. Industrial Bio-Test Laboratories, Inc. (1973, cited in WHO 1986), determined the irritation threshold in ten human volunteers exposed to ammonia at concentrations of 32, 50, 72, or 134 ppm for 5 min. Irritation was defined as any discomfort in the nose, throat, eyes, mouth, or chest. The subjects showed dose-related responses for chest irritation and dryness of the eye, nose, and throat. The severity of the effects was not noted. 

Industrial Bio-Test Laboratories, Inc. 1973. Irritation Threshold Evaluation Study with Ammonia, Industrial Bio-Test Laboratories, Inc. (Report to International Institute of Ammonia Refrigeration, Publication No. 663-03161). 

Mastri C, Keplinger ML, Eancher OE (1969) Acute Toxicity Studies on X-801-25. Industrial Bio-test Laboratories (IBT), Northbrook, Illinois... 

On April 5, 1974, OSHA, based on this information, promulgated an Emergency Temporary Standard that reduced the level from 500 ppm to a 50 ppm ceiling. Ten days later, on April 15, 1974, Industrial Bio-Test Laboratories, where the MCA animal study was being carried out, reported to OSHA, NIOSH, and EPA that 2 of 200 mice exposed to 50 ppm of VCM for 7 h/d, 5 d/wk, for approximately 7 mo had developed liver angiosarcoma. This result was not observed in rats or hamsters. OSHA therefore concluded that exposure even to 50 ppm might well constitute a serious health hazard. 

Respiratory Effects. Ammonia is an upper respiratory irritant in humans. Exposures to levels exceeding 30 ppm result in immediate irritation to the nose and throat (Industrial Bio-Test Laboratories 1973 MacEwen et al. 1970 Sekizawa and Tsubone 1994 Verberk 1977). Four out of six human subjects described moderate irritation of the nose and eyes when exposed to 50, but not 30, ppm ammonia gas for 10 minutes (MacEwen et al. 1970). Twenty to 30% of subjects exposed to 72, but not 50, ppm ammonia gas for 5 minutes experienced eye, nasal, and throat irritation (Industrial Bio-Test Laboratories... 

The four-day TL (medium tolerance limit) values have been determined for fish. According to experiments on young fish, 5-10 cm long, the TL of chlorbromuron for rainbow trout (Salmo gardineri) is 0.56 ppm, for channel catfish (Ictalurus punctatus) 11 ppm, and for bluegill (Lepomis macrochirus) 7.5 ppm. In comparative tests, the TL values of DDT varied between > 0.01 and < 0.05 ppm (Industrial Bio-Test Laboratories, 1965-1967). 

Industrial Bio Test Laboratories Inc., Northbrook, Illinois, (1965-1967) Ciba Co., Agrochemical Company, USA. 

Baker, R.R., S. Cobum, C. Liu, and J. Tetteh Pyrolysis of saccharide tobacco ingredients A TGA-FTIR investigation J. Anal. Appl. Pyrol. 74 (2005) 171-180. Industrial Bio-Test Laboratories, Inc. InterimReportNo. 15 to R. J. Reynolds Tobacco Company—Saliva-soluble components of tobacco smoke RDR, 1966, No. 30, July 26, see www.ijrtdocs.com 500967353 -7353 Interim Report No. 16 to R. J. Reynolds Tobacco Company— The effects of sahva-soluble cihastatic components of tobacco smoke on the cat trachea in vivo RDR, 1966, No. 34, September 2, see www.rirtdocs.com 521184202 A221. 

Kay, J.H., and J.C. Calandra. 1961. Unpublished report by industrial bio-test laboratories Cited in WHO. 1982. Annatto extracts. Toxicological evaluation of certain food additives. WHO Food Additives Series, No. 17. 

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