Pharmacological screens

Staley J., Ouyang Q., Pablo J. et al. Pharmacological screen for activities of 12-hydroxyibogamine a primary metabolite of the indole alkaloid ibogaine. Psychopharmacology. 127 10, 1996. 

Martin, L.I., Horvath, C.J. and Wyand, M.S. (1997). Safety pharmacology screening practical problems in drug development. Int. J. Toxicol. 16 41-65. 

Zbinden, G. (1966). The significance of pharmacologic screening tests in the preclinical safety evaluation of new drugs. J. New Drugs 6 1-7. 

In 1970, Rice et al. studied a diverse range of 3-substituted 1,2,3,4-tetrahydrocarba-zole derivatives in a preliminary pharmacological screening for general stimulation, depression, and autonomic activity, and found that 3-carboethoxy-9-(3-dimethyl-aminopropyl)-l,2,3,4-tetrahydrocarbazole (461) exhibited growth inhibition at a concentration of 1 gg/mL in mammary carcinoma tissue (400). These studies were based on the carcinogenic activity observed for the bis-angular bis-benzocarbazoles reported by Buu-Hoi et al. (401). 

Vieira, J. E. V., G. S. G. Barros, M. C. Medeiros, F. J. A. Matos, M. P. Souza and M. J. Medeiros. Pharmacologic screening of plants from Northeast Brazil. II. Rev Brasil Farm 1968 49 67-75. Dixit, V. P., V. N. Sharma and N. K. Lohiya. The effect of chronically administered cannabis extract on the testicular function of mice. Eur J Pharmacol 1974 26 111-114. Pinheiro de Sousa, M. and M. Z. Rouquayrol. Molluscicidal activity of plants from Northeast Brazil. Rev Bras... 

H. A. Donia. Chemical characterization and preliminary pharmacological screening of the bitter principle iso- DC186 lated from Daucus carota L. var. boissieri Schweinf. growing in Egypt. J Drug Res (Egypt) 1979 11 115-120. 

Some areas where ortho esters have found use involve the elucidation of the structure proof of polyhydroxy alkaloids [4-8], the protection of the esterified hydroxyl groups during chemical transformations of the other parts of the molecule [9], the area of pharmacological screening [10], and the preparation of novel polymers [11]. 

Detailed biological or pharmacological screenings were performed also in cooperation with scientists in different laboratories. 

Many other synthetic indoles have exhibited various types of activity in pharmacological screening. Much of this information is summarized in a recent review (78MI30601). 

V. In vivo pharmacology pharmacokinetics pharmacology screening Animal Determine pharmacokinetic profile of ohgos, i.e., absorption, distribution, metabolism, and elimination Determine pharmacological effects of ohgos on host tissues other than desired effects... 

---