INDEX inhibition

Chem. Descrip. Polyoxyalkylene glycol ether Uses Lubricant defoamer solvent Features Syn. high vise, index inhibited version of Icinol H260 Hydrol H660 [Huntsman]... 

The therapeutic efficacy of a dmg is generally measured in terms of ED q or ID q which represent the concentration of dmg which produces 50% of the maximum effect or 50% of maximum inhibition. LD q represents the concentration of dmg that produces 50% fataUties in test animals. The therapeutic index is the ratio of the ED q versus LD q. Detailed descriptions of the terminology and fundamental principles of pharmacology are available (32) (see Pharmacodynamics). 

Purified monomer is usually inhibited before shipment by such materials as copper resinate, diphenylamine or hydroquinone, which are generally removed before polymerisation. The monomer is a sweet-smelling liquid partially miscible with water and with the following properties boiling point at 760mmHg, 72.5°C specific gravity at 20°C, 0.934 refractive index 1.395 vapour... 

Inhalts-ubersicht, /. — Inhaltsangabe. -ver-zeichnis, n. table of contents index, inh ent, a. inherent, inhibieren, v.t. inhibit, stay, stop, inhomogen, a. inhomogeneous. Inhomogenitkt,/. inhomogeneity. 

Polythiosemicarbazide disulfide is the most efficient aliphatic polyamine disulfide for inhibiting the thermal oxidative breakdown of polypropylene, while polyimi-noaniline disulfide and polydiiminodiphenyloxide disulfide (Fig. 3) are the most efficient aromatic polyamine disulfides. In contrast to polyethylene, the thermal oxidative breakdown period increases as the concentration increases (Fig. 4), Depending on the concentration, the flow-melt index at 230°C increases at a lower rate than in the case of commercial stabilizer Santanox (Table 2)-... 

Exposure of two species of freshwater fish to 0.106 ppb of a commercial formulation containing 50% methyl parathion increased serum levels of T3 and reduced T4 (Bhattacharya 1993). This effect was attributed to inhibition of acetylcholinesterase activity in the fish brain, but no direct evidence was presented. Similar treatment of freshwater perch for 35 days resulted in decreased release of progesterone from the ovaries (Bhattacharya and Mondal 1997). Also, treatment of freshwater perch for up to 90 days with methyl parathion induced a decrease in the gonadosomatic index (not defined) after day 15 of... 

The measurement of inhibition of brain AChE is a valuable biomarker assay for OPs and carbamates and is not jnst an index of exposure. Being an assay based on... 

CoMSIA (comparative molecular similarity index analysis) is a recent development from CoMFA and does not suffer from the alignment problem. It has been used to model hERG potassium channel inhibition by drugs [59] and the toxicity of phenylsulfonyl carboxylates [60], organophosphates [61], and polybrominated diphenyl ethers [62], with results comparable to those from CoMFA. 

As 1,2,5-thiadiazole analogues, potent HlV-1 reverse transcriptase inhibitors, some simple 1,2,5-oxadiazoles, compounds 4-6 (Fig. 9), have been synthesized using the traditional Wieland procedure as key for the heterocycle formation [121]. Such as thiadiazole parent compounds, derivative with chlorine atoms on the phenyl ring, i.e., 5, showed the best anti-viral activity. Selectivity index (ratio of cytotoxic concentration to effective concentration) ranked in the order of 5 > 6 > 4. The activity of Fz derivative 6 proved the N-oxide lack of relevance in the studied bioactivity. These products have been claimed in an invention patent [122]. On the other hand, compound 7 (Fig. 9) was evaluated for its nitric oxide (NO)-releasing property (see below) as modulator of the catalytic activity of HlV-1 reverse transcriptase. It was found that NO inhibited dose-dependently the enzyme activity, which is hkely due to oxidation of Cys residues [123]. 

Theophylline is also considered an alternative to inhaled corticosteroids for the treatment of mild persistent asthma however, limited efficacy compared to inhaled corticosteroids, a narrow therapeutic index with life-threatening toxicity, and multiple clinically important drug interactions have severely limited its use. Theophylline causes bronchodilation through inhibition of phosphodiesterase and antagonism of adenosine and appears to have anti-inflammatory and immunomodulatory properties as well.36... 

Colchicine has a long history of successful use and was the treatment of choice for many years. It is used infrequently today because of its low therapeutic index. Colchicine is thought to exert its anti-inflammatory effects by interfering with the function of mitotic spindles in neutrophils by binding of tubulin dimers this inhibits phagocytic activity. 

The determination of F2-isoprostanes, oxidation products of arachidonic acid, has been proposed as a more reliable index of oxidative stress in vivo, overcoming many of the methodological problems associated with other markers. The isoprostanes have emerged as a most effective method of quantifying the potential of antioxidants to inhibit lipid peroxidation. However, one drawback of this method is that quantification of F2-iP requires sophisticated techniques, in particular GC/MS and HPLC/MS... 

---