INDEX amination

In the flask were placed 10.0 g of the propargylic amine (see Chapter lIII-5, Exp. 1). The air in the flask was replaced with nitrogen and a solution of 0.01 mol of KO-tert.-Ci,H,3 in 10 g of THF (free from hydroperoxide) was added. The mixture was warmed at about 40 C. A weakly exothermic reaction was observed and the temperature rose to about 45°C. After 1-2 min the gel originally present, had disappeared almost completely and a brown solution had formed. The refractive index of the solution (note 1) was measured after intervals of about 2 min. After the... 

Table 4 lists the specifications set by Du Pont, the largest U.S. producer of DMF (4). Water in DMF is deterrnined either by Kad Fischer titration or by gas chromatography. The chromatographic method is more rehable at lower levels of water (<500 ppm) (4). DMF purity is deterrnined by gc. For specialized laboratory appHcations, conductivity measurements have been used as an indication of purity (27). DMF in water can be measured by refractive index, hydrolysis to DMA followed by titration of the Hberated amine, or, most conveniendy, by infrared analysis. A band at 1087 cm is used for the ir analysis. 

Cycloaliphatic amine CAS Registry Number Molecular formula Boiling point, °C Flash point, °C Specific gravity, g/mL Refractive index. 

On the basis of data obtained the possibility of substrates distribution and their D-values prediction using the regressions which consider the hydrophobicity and stmcture of amines was investigated. The hydrophobicity of amines was estimated by the distribution coefficient value in the water-octanole system (Ig P). The molecular structure of aromatic amines was characterized by the first-order molecular connectivity indexes ( x)- H was shown the independent and cooperative influence of the Ig P and parameters of amines on their distribution. Evidently, this fact demonstrates the host-guest phenomenon which is inherent to the organized media. The obtained in the research data were used for optimization of the conditions of micellar-extraction preconcentrating of metal ions with amines into the NS-rich phase with the following determination by atomic-absorption method. 

Eor amine-containing polymers, DMF is often a good choice of solvent. DMF can also be a good choice for polymers of higher carboxylic acid content. However, DMF does present some experimental difficulties. It must be run at an elevated temperature, typically 60°C, because of its viscosity. Also, because most polymers have a much lower refractive index response in DMF, the signal-to-noise ratio for a polymer in this solvent is diminished versus the same ratio for common acrylates in THF. 

The residue comprising chiefly cyclopentylacetonitrile is washed with dilute hydrochloric acid to remove any amine which may have been formed during the hydrogenation process, and the organic residue comprising cyclopentylacetonitrile is dissolved in ether, the ether solution dried over anhydrous magnesium sulfate and distilled. The cyclopentylacetonitrile boils at 185° to 187°C and has a refractive index of no = 1.4456. 

Common names of the compounds arc used throughout this volume. Preparations appear in the alphabetical order of common names of the compound or names of the synthetic procedures. The Chemical Abstracts indexing name for each title compound, if it differs from the common name, is given as a subtitle. Because of the major shift to new systematic nomenclature adopted by Chemical Abstracts in 1972, many common names used in the text are immediately followed by the bracketed, new names. Whenever two names are concurrently in use, the correct Chemical Abstracts name is adopted. The prefix n- is deleted from w-alkanes and w-alkyls. In the case of amines, both the common and systematic names are used, depending on which one the Editor-in-Chief feels is more appropriate. All reported dimensions are now expressed in Systeme International units. 

Examples of the protection of alkynes, carboxylic acids, alcohols, phenols, aldehydes, amides, amines, esters, ketones, and alkenes are also indexed on p. xvii. Section (designated with an A 15A, 30A, etc.) with protecting group reactions are located at the end of pertinent chapters. 

Such difficulties prompted research workers to look for some other index of NT function in humans. These range from studies on platelets, such as abnormalities in their amine uptake and MAO activity in depressed patients, to changes in the secretion of a hormone known to be controlled by a particular NT. Thus if NA controls growth hormone release, and the secretion of the hormone is changed in depressed patients, does that confirm a role for NA in the mediation of depression ... 

There have been some examples of the use of LDMS applied to the analysis of compounds separated via TLC, although not specifically dealing with polymer additives [852]. Dewey and Finney [838] have described direct TLC-spectroscopy and TLC-LMMS as applied to the analysis of lubricating oil additives (phenolic and amine antioxidants, detergents, dispersants, viscosity index improvers, corrosion inhibitors and metal deactivators). Also a series of general organics and ionic surfactants were analysed by means of direct normal-phase HPTLC-LMMS [837]. Novak and Hercules [858] have... 

The behavior of the different amines depends on at least four factors basicity, nucleophilicity, steric hindrance and solvation. In the literature (16), 126 aliphatic and aromatic amines have been classified by a statistical analysis of the data for the following parameters molar mass (mm), refractive index (nD), density (d), boiling point (bp), molar volume, and pKa. On such a premise, a Cartesian co-ordinate graph places the amines in four quadrants (16). In our preliminary tests, amines representative of each quadrant have been investigated, and chosen by consideration of their toxicity, commercial availability and price (Table 1). 

Although treated as separate classes in the Colour Index, these structural types are closely related and the few diphenylmethane dyes such as auramine (1.28 Cl Basic Yellow 2) are now of little practical interest. Commercial usage of the triarylmethane dyes and pigments has also declined considerably in favour of the major chemical classes. They were formerly noteworthy contributors to the acid, basic, mordant and solvent ranges, primarily in the violet, blue and green sectors. Numerous structural examples are recorded in the Colour Index. The terminal groupings can be amine/quinonimine, as in auramine and crystal violet (1.29 Cl Basic Violet 3), hydroxy/quinone, or both. The aryl nuclei are not always benzenoid (section 6.5). 

In the Colour Index both conventional sulphur dyes and their leuco counterparts are allocated the same Cl constitution number a different number is given to the related solubilised version. Thus, for example, Cl Sulphur Black 1 and Cl Leuco Sulphur Black 1 have the reference Cl 53185 whereas Cl Solubilised Sulphur Black 1 appears under Cl 53186. Because of the complexity of the final products, sulphur dyes are classified according to the chemical structure of the organic starting material that predominates in the manufacturing process. Typical intermediates include aromatic amines, with or without nitro and phenolic groups, and diphenylamine derivatives. 

The most important route to 1-acylaminoanthraquinones involves reaction of 1-aminoanthraquinone with acid chlorides in an organic solvent. Reaction of 1-aminoanthraquinone with benzoylchloride in nitrobenzene at 100 to 150°C affords 1-benzoylaminoanthraquinone, a yellow pigment which is registered as Colour Index Constitution No. 60515. The reaction may also be performed in the presence of a tertiary amine, which acts as a proton acceptor ... 

An appendix systematically lists references to reactions of dialkylalkoxy-malonates with amines, including not only the common aliphatic and aromatic amines, but also a very wide variety of heterocyclic amines classified according to ring system. The appendix also provides systematic references to the different ring systems obtained by ring closure of the dialkylaminomethylenemalonates. The appendix should be used in conjunction with the subject index a separate subject index is provided for this monograph volume. 

A comparative study of the analysis of aliphatic amines by GC-FID, GC-TSD and HPLC with refractive index detector (RID), using isopropylamine as internal standard, gave good results in all cases. Determination of trimethylamine oxide by HPLC with a pulsed amperometric detector was problematic136. 

Datta, R. L. et al., J. Chem. Soc., 1919, 115, 1006-1010 Many perchlorate salts of amines explode in the range 215-310°C, and some on impact at ambient temperature. Individually indexed compounds are to be found in the group entries ... 

This group of compounds, previously described as amine perchromates , is characterised by the presence of basic nitrogen and peroxo ligands within the same coordination sphere. This creates a high tendency towards explosive decomposition, which sometimes apparently occurs spontaneously. Individually indexed compounds are ... 

Most of the isolated diacyl (including sulfonyl) peroxides are solids with relatively low decomposition temperatures, and are explosive, sensitive to shock, heat or friction. Several, particularly the lower members, will detonate on the slightest disturbance. Autocatalytic (self-accelerating) decomposition, which is promoted by tertiary amines, is involved [1]. Solvents suitable for preparation of safe solutions of diacetyl, dipropionyl, diisobutyryl and di-2-phenylpropionyl peroxides are disclosed [2], The class is reviewed, including hazards and safety measures [3], Cyclic diacyl peroxides are more stable, but scarcely to be trusted. Individually indexed compounds are ... 

Of the 3 possible types of peroxy carbonate esters-dialkyl monoperoxy carbonates, dialkyl diperoxycarbonates and dialkyl peroxydicarbonates-, the latter are by far the least stable group. Several of the 16 alkyl and substituted-alkyl esters prepared decomposed violently or explosively at temperatures only slightly above the temperature of preparation (0-10°C), owing to self-accelerating exothermic decomposition. Several were also explosive on exposure to heat, friction or shock [1], Amines and certain metals cause accelerated decomposition of dialkyl peroxydicarbonates by a true catalytic mechanism [2], Individually indexed compounds are ... 

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