Secondary amine INDEX

Secondary amines are more noradrenergic Clomipramine is primarily serotonergic Narrow therapeutic index Overdoses can be fatal Anticholinergic (dry mouth, constipation, blurred vision)... 

Those who fail to respond to an SSRI may respond to a TCA, and vice versa. Thus, these two broad-spectrum classes can be used in a sequential strategy to adequately treat the majority of cases. However, many physicians try another newer antidepressant (e.g, venlafaxine, bupropion, nefazodone) in such patients because of the safety and tolerability problems associated with TCAs. Of note, the tolerability profile of secondary amine TCAs such as desipramine is as favorable as any of the newer antidepressants and probably better than nefazodone. Nevertheless, the secondary amine TCAs have a therapeutic index as narrow as tertiary amine TCAs (e.g., amitriptyline, imipramine) in terms of lethality in overdoses resulting from cardiotoxicity. 

Development Worksheet for SPE (Fig. 3.2). The structure for atrazine shows that it contains a triazine ring with two secondary amines. The aqueous solubility is 33 mg/L, and the compound is quite soluble in methanol, ethyl acetate, and chloroform. List these solvents on the worksheet in Figure 3.2 as possible elution solvents. The pA", of atrazine is not given in the Merck Index, but a quick literature search shows that the is less than 2.0. Furthermore, the compound is stable in water and the pH range of samples will be from 5 to 8. This information may be recorded on the worksheet together with the pAT, and pH of the sample. 

However, the addition of sulfur to solvents such as n-butylamine, di-n-butylamine, tri-n-butylamine, triethylamine, morpholine, and ethylenedi-amine yields more highly colored solutions. In these, solvents the relationship between the extinction coefficient, e, and N, the refractive index is not obeyed. Further, two types of behavior are observed. Sulfur in the primary and secondary amines (ii-butylamine, ethylenediamine, di-n-butylamine, and morpholine) dissolves with considerable heat of solution to produce solutions containing numerous ions as measured by a conductance bridge. The following reaction is consistant with these data. 

Only one of the primary amines is coordinated in Example 3. This is indicated by not using the doubling prefix bis , repeating (2-aminoethyl), and inserting the k index only in the first such unit, i.e. (2-amino-K/V-ethyl). The involvement of both of the secondary ethane-1,2-diamine nitrogen atoms in chelation is indicated by the index k2N,N. ... 

The list of secondary sources reviewing the chemistry of thiazoles previously given is supplemented by the following publications. Prijs Card Index of Thiazole Compounds provides swift access to information on individual compounds, but its appearance has unfortunately not continued. Asinger and Oflfermanns have reviewed the chemistry of A -thiazolines, within the framework of a full account of their versatile synthesis of heterocyclic compounds by the simultaneous action of sulphur and amines on ketones. Ohta and Kato s comprehensive survey on sydnones includes a section on mesionic thiazoles. 

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